{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T06:24:09Z","timestamp":1775197449342,"version":"3.50.1"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T00:00:00Z","timestamp":1583280000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Spanish Ministry of Economy and Competitiveness","award":["SAF2013-48971-C2-1-R"],"award-info":[{"award-number":["SAF2013-48971-C2-1-R"]}]},{"name":"Spanish Ministry of Economy and Competitiveness","award":["CSD2010-00065"],"award-info":[{"award-number":["CSD2010-00065"]}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"ERDF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"name":"FPU Grant","award":["FPU14\/01537"],"award-info":[{"award-number":["FPU14\/01537"]}]},{"name":"Ministry of Education of Spain"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>We report the in vivo trypanocidal activity of the bacteriocin AS-48 (lacking toxicity), which is produced by Enterococcus faecalis, against the flagellated protozoan Trypanosoma cruzi, the aetiological agent of Chagas\u2019 disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We determined the in vivo activity of AS-48 against the T. cruzi Arequipa strain in BALB\/c mice (in both acute and chronic phases of Chagas\u2019 disease). We evaluated the parasitaemia, the reactivation of parasitaemia after immunosuppression and the nested parasites in the chronic phase by PCR in target tissues.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>AS-48 reduced the parasitaemia profile in acute infection and showed a noteworthy reduction in the parasitic load in chronic infection after immunosuppression according to the results obtained by PCR (double-checking to demonstrate cure).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>AS-48 is a promising alternative that provides a step forward in the development of a new therapy against Chagas\u2019 disease.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkaa030","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T12:37:17Z","timestamp":1579610237000},"page":"1537-1545","source":"Crossref","is-referenced-by-count":24,"title":["Assessing the effectiveness of AS-48 in experimental mice models of Chagas\u2019 disease"],"prefix":"10.1093","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6262-9344","authenticated-orcid":false,"given":"Rub\u00e9n","family":"Mart\u00edn-Escolano","sequence":"first","affiliation":[{"name":"Department of Parasitology, Instituto de Investigaci\u00f3n Biosanitaria (ibs.Granada), Hospitales Universitarios De Granada\/University of Granada, Severo Ochoa s\/n, E-18071 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rub\u00e9n","family":"Cebri\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Sciences, Avda. Fuentenueva s\/n, University of Granada, 18071 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mercedes","family":"Maqueda","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Sciences, Avda. Fuentenueva s\/n, University of Granada, 18071 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Desir\u00e9e","family":"Romero","sequence":"additional","affiliation":[{"name":"Department of Statistics and Operations Research, Faculty of Sciences, Avda. 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