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However, malaria still results in the deaths of thousands of people every year. Malaria is caused by Plasmodium spp., parasites transmitted through the bite of an infected female Anopheles mosquito. Treatment timing plays a decisive role in reducing mortality and sequelae associated with the severe forms of the disease such as cerebral malaria (CM). The available antimalarial therapy is considered effective but parasite resistance to these drugs has been observed in some countries. Antimalarial drugs act by increasing parasite lysis, especially through targeting oxidative stress pathways. Here we discuss the roles of reactive oxygen species and reactive nitrogen intermediates in CM as a result of host\u2013parasite interactions. We also present evidence of the potential contribution of oxidative and nitrosative stress-based antimalarial drugs to disease treatment and control.<\/jats:p>","DOI":"10.1093\/jac\/dkaa032","type":"journal-article","created":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T15:09:35Z","timestamp":1579532975000},"page":"1363-1373","source":"Crossref","is-referenced-by-count":3,"title":["Oxidative and nitrosative stresses in cerebral malaria: can we target them to avoid a bad prognosis?"],"prefix":"10.1093","volume":"75","author":[{"given":"Domingos Magno Santos","family":"Pereira","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o, Universidade CEUMA , S\u00e3o Lu\u00eds, MA,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexsander Rodrigues","family":"Carvalho J\u00fanior","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o, Universidade CEUMA , S\u00e3o Lu\u00eds, MA,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliza Maria da Costa Brito","family":"Lacerda","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o, Universidade CEUMA , S\u00e3o Lu\u00eds, MA,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Cl\u00e1udio Nascimento","family":"da Silva","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o, Universidade CEUMA , S\u00e3o Lu\u00eds, MA,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udio Romero Farias","family":"Marinho","sequence":"additional","affiliation":[{"name":"Departamento de Parasitologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade de S\u00e3o Paulo , S\u00e3o Paulo, SP,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunice","family":"Andr\u00e9","sequence":"additional","affiliation":[{"name":"Departamento de Farmacologia, Universidade Federal do Paran\u00e1 , Curitiba, PR,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0567-2514","authenticated-orcid":false,"given":"Elizabeth Soares","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o, Universidade CEUMA , S\u00e3o Lu\u00eds, MA,","place":["Brazil"]},{"name":"Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe , Curitiba, PR,","place":["Brazil"]},{"name":"Faculdades Pequeno Pr\u00edncipe , Curitiba, 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