{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:09:39Z","timestamp":1790359779731,"version":"4.1.0"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T00:00:00Z","timestamp":1583798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003323","name":"Agence Nationale de Recherches sur le SIDA et les h\u00e9patites virales","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003323","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>GS-6207 is a first-in-class HIV capsid inhibitor, targeting several functions of the HIV capsid in the viral cycle, including viral particle assembly, capsid formation and nuclear entry. GS-6207 has demonstrated picomolar potency in vitro, activity confirmed by high potency in a Phase 1 clinical study, with a long-acting antiretroviral profile with potential dosing every 6\u2009months. In vitro resistance selections previously conducted with increasing doses of GS-6207 have identified capsid variants with reduced susceptibility to GS-6207.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To study the prevalence of capsid mutations associated with in vitro resistance to GS-6207 in people living with HIV (PLWH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Plasma samples from ART-naive or -experienced PLWH, including PI-experienced people, were sequenced and analysed for the presence of capsid variants identified during in vitro resistance selection: L56I, M66I, Q67H, K70N, N74D, N74S and T107N.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the samples from the 1500 patients studied, none of the seven GS-6207 resistance mutations identified during in vitro selection experiments was detected, regardless of HIV subtype or PLWH treatment history.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Out of the seven HIV capsid substitutions previously selected in vitro and shown to confer phenotypic resistance to GS-6207, none of these seven mutations was observed in this large dataset, suggesting that neither PLWH with previous PI failure nor PLWH with emergence of PI resistance mutations are anticipated to impact GS-6207 activity in these diverse HIV-infected populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jac\/dkaa060","type":"journal-article","created":{"date-parts":[[2020,2,4]],"date-time":"2020-02-04T07:13:08Z","timestamp":1580800388000},"page":"1588-1590","source":"Crossref","is-referenced-by-count":62,"title":["Frequency of capsid substitutions associated with GS-6207 in vitro resistance in HIV-1 from antiretroviral-naive and -experienced patients"],"prefix":"10.1093","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4808-8999","authenticated-orcid":false,"given":"Anne-Genevi\u00e8ve","family":"Marcelin","sequence":"first","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique, AP-HP, H\u00f4pitaux Universitaires Piti\u00e9-Salp\u00eatri\u00e8re - Charles Foix, Laboratoire de Virologie, F75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Charpentier","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Paris, IAME, UMR1137, INSERM, Laboratoire de Virologie, H\u00f4pital Bichat-Claude Bernard, AP-HP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aude","family":"Jary","sequence":"first","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique, AP-HP, H\u00f4pitaux Universitaires Piti\u00e9-Salp\u00eatri\u00e8re - Charles Foix, Laboratoire de Virologie, F75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Perrier","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Paris, IAME, UMR1137, INSERM, Laboratoire de Virologie, H\u00f4pital Bichat-Claude Bernard, AP-HP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0911-4237","authenticated-orcid":false,"given":"Nicolas","family":"Margot","sequence":"first","affiliation":[{"name":"Gilead Sciences, Foster City, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Callebaut","sequence":"first","affiliation":[{"name":"Gilead Sciences, Foster City, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Calvez","sequence":"first","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique, AP-HP, H\u00f4pitaux Universitaires Piti\u00e9-Salp\u00eatri\u00e8re - Charles Foix, Laboratoire de Virologie, F75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Descamps","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Paris, IAME, UMR1137, INSERM, Laboratoire de Virologie, H\u00f4pital Bichat-Claude Bernard, AP-HP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,3,10]]},"reference":[{"key":"2020051504584685100_dkaa060-B1","doi-asserted-by":"crossref","first-page":"1227.","DOI":"10.3389\/fmicb.2019.01227","article-title":"GS-CA compounds: first-in-class HIV-1 capsid inhibitors covering multiple grounds","volume":"10","author":"Singh","year":"2019","journal-title":"Front Microbiol"},{"key":"2020051504584685100_dkaa060-B2","author":"Yant"},{"key":"2020051504584685100_dkaa060-B3","author":"Sager"},{"key":"2020051504584685100_dkaa060-B4","author":"Sager"},{"key":"2020051504584685100_dkaa060-B5","author":"Daar"},{"key":"2020051504584685100_dkaa060-B6","author":"Yant"},{"key":"2020051504584685100_dkaa060-B7","doi-asserted-by":"crossref","first-page":"2954","DOI":"10.1093\/jac\/dkx208","article-title":"Prevalence of gag mutations associated with in vitro resistance to capsid inhibitor GS-CA1 in HIV-1 antiretroviral-naive patients","volume":"72","author":"Perrier","year":"2017","journal-title":"J Antimicrob Chemother"},{"key":"2020051504584685100_dkaa060-B8","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1093\/jac\/dkz151","article-title":"New mechanisms of resistance in virological failure to protease inhibitors: selection of non-described protease, Gag and Gp41 mutations","volume":"74","author":"Castain","year":"2019","journal-title":"J Antimicrob Chemother"},{"key":"2020051504584685100_dkaa060-B9","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1093\/jac\/dkn338","article-title":"Impact of gag mutations on selection of darunavir resistance mutations in HIV-1 protease","volume":"62","author":"Lambert-Niclot","year":"2008","journal-title":"J Antimicrob Chemother"},{"key":"2020051504584685100_dkaa060-B10","first-page":"111","article-title":"2019 update of the drug resistance mutations in HIV-1","volume":"27","author":"Wensing","year":"2019","journal-title":"Top Antivir Med"},{"key":"2020051504584685100_dkaa060-B11","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1128\/AAC.01784-09","article-title":"Phenotypic susceptibility to bevirimat in isolates from HIV-1-infected patients without prior exposure to bevirimat","volume":"54","author":"Margot","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"2020051504584685100_dkaa060-B12","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1038\/s41591-019-0560-x","article-title":"A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model","volume":"25","author":"Yant","year":"2019","journal-title":"Nat Med"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/75\/6\/1588\/33213974\/dkaa060.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/75\/6\/1588\/33213974\/dkaa060.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T16:30:45Z","timestamp":1589646645000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article\/75\/6\/1588\/5802529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,10]]},"references-count":12,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,3,10]]},"published-print":{"date-parts":[[2020,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dkaa060","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,6]]},"published":{"date-parts":[[2020,3,10]]}}}