{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T01:15:22Z","timestamp":1788311722507,"version":"build-2803163510"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T00:00:00Z","timestamp":1585008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23 AI104315"],"award-info":[{"award-number":["K23 AI104315"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI122298"],"award-info":[{"award-number":["R01 AI122298"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine factors associated with interindividual variability in tenofovir diphosphate (TFV-DP) concentrations in dried blood spots (DBSs) among persons living with HIV (PLWH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PLWH who were at least 18\u2009years old and taking tenofovir disoproxil fumarate-containing ART were prospectively recruited and enrolled from a clinical cohort and followed longitudinally (up to three visits over 48\u2009weeks). With log-transformed TFV-DP concentrations in DBSs as the outcome, mixed-model regression analyses were used to assess associations between self-reported 3\u2009month ART adherence, race and other clinical covariates (gender, age, BMI, CD4+ T cell count, estimated glomerular filtration rate, haematocrit, duration on current ART and anchor drug class) on TFV-DP in DBSs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five hundred and twenty-seven participants (1150 person-visits) were analysed. Adjusting for race and other clinical covariates, every 10% increase in self-reported 3\u2009month ART adherence was associated with an average TFV-DP concentration increase in DBSs of 28% (95% CI: 24%\u201332%; P\u2009&amp;lt;\u20090.0001). In the same model, female participants had 20% (95% CI: 3%\u201340%; P\u2009=\u20090.02) higher TFV-DP concentrations in DBSs, compared with male participants, and every 1\u2009kg\/m2 increase in BMI was associated with a decrease in TFV-DP concentration in DBSs by 2% (95% CI: \u22123% to \u22121%; P\u2009&amp;lt;\u20090.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Individual patient characteristics were predictive of TFV-DP concentration in DBSs in PLWH receiving tenofovir disoproxil fumarate-based ART. Future research to incorporate these predictors into the interpretation of this ART adherence biomarker, and to establish whether these associations extend to PLWH taking tenofovir alafenamide-containing ART, is needed.<\/jats:p><\/jats:sec>","DOI":"10.1093\/jac\/dkaa070","type":"journal-article","created":{"date-parts":[[2020,2,8]],"date-time":"2020-02-08T05:25:32Z","timestamp":1581139532000},"page":"1591-1598","source":"Crossref","is-referenced-by-count":23,"title":["Factors associated with tenofovir diphosphate concentrations in dried blood spots in persons living with HIV"],"prefix":"10.1093","volume":"75","author":[{"given":"Ryan P","family":"Coyle","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, School of Medicine, University of Colorado-AMC, Aurora, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Morrow","sequence":"first","affiliation":[{"name":"Department of Biostatistics and Bioinformatics, Colorado School 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