{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T15:19:53Z","timestamp":1784647193129,"version":"3.55.0"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T00:00:00Z","timestamp":1586995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Equipe FRM 2016","award":["DEQ20161136698"],"award-info":[{"award-number":["DEQ20161136698"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The resistance to all aminoglycosides (AGs) conferred by 16S rRNA methyltransferase enzymes (16S-RMTases) is a major public health concern.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To characterize the resistance genotype, its genetic environment and plasmid support, and the phylogenetic relatedness of 16S-RMTase-producing Escherichia coli from France.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We screened 137 E. coli isolates resistant to all clinically relevant AGs from nine Parisian hospitals for 16S-RMTases. WGS was performed on clinical isolates with high-level AG resistance (MIC \u2265256\u2009mg\/L) and their transformants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Thirty of the 137 AG-resistant E. coli produced 16S-RMTases: 11 ArmA, 18 RmtB and 1 RmtC. The 16S-RMTase producers were also resistant to third-generation cephalosporins (90% due to a blaCTX-M gene), co-trimoxazole, fluoroquinolones and carbapenems (blaNDM and blaVIM genes) in 97%, 83%, 70% and 10% of cases, respectively. Phylogenomic diversity was high in ArmA producers, with 10 different STs, but a similar genetic environment, with the Tn1548 transposon carried by a plasmid closely related to pCTX-M-3 in 6\/11 isolates. Conversely, RmtB producers belonged to 12 STs, the most frequent being ST405 and ST complex (STc) 10 (four and four isolates, respectively). The rmtB gene was carried by IncF plasmids in 10 isolates and was found in different genetic environments. The rmtC gene was carried by the pNDM-US plasmid.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>ArmA and RmtB are the predominant 16S-RMTases in France, but their spread follows two different patterns: (i) dissemination of a conserved genetic support carrying armA in E. coli with high levels of genomic diversity; and (ii) various genetic environments surrounding rmtB in clonally related E. coli.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkaa105","type":"journal-article","created":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T04:44:15Z","timestamp":1583729055000},"page":"1726-1735","source":"Crossref","is-referenced-by-count":25,"title":["Genomic characterization of 16S rRNA methyltransferase-producing Escherichia coli isolates from the Parisian area, France"],"prefix":"10.1093","volume":"75","author":[{"given":"Fran\u00e7ois","family":"Cam\u00e9l\u00e9na","sequence":"first","affiliation":[{"name":"AP-HP, Service de Microbiologie, H\u00f4pital Saint-Louis, Paris, France"},{"name":"Universit\u00e9 de Paris, INSERM, IAME, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Morel","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Paris, INSERM, IAME, Paris, France"},{"name":"AP-HP, Service de Bact\u00e9riologie-Virologie, H\u00f4pital Lariboisi\u00e8re, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manel","family":"Merim\u00e8che","sequence":"first","affiliation":[{"name":"AP-HP, Service de Microbiologie, H\u00f4pital Saint-Louis, Paris, France"},{"name":"Universit\u00e9 de Paris, INSERM, IAME, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Winoc","family":"Decousser","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Paris, INSERM, IAME, Paris, France"},{"name":"AP-HP, Service de Bact\u00e9riologie et d\u2019Hygi\u00e8ne Hospitali\u00e8re, H\u00f4pital Henri Mondor, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Jacquier","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Paris, INSERM, IAME, Paris, France"},{"name":"AP-HP, Service de Bact\u00e9riologie-Virologie, H\u00f4pital Lariboisi\u00e8re, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Clermont","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Paris, INSERM, IAME, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Darty","sequence":"first","affiliation":[{"name":"AP-HP, Service de Bact\u00e9riologie et d\u2019Hygi\u00e8ne Hospitali\u00e8re, H\u00f4pital Henri Mondor, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Mainardis","sequence":"first","affiliation":[{"name":"AP-HP, Service de Microbiologie, H\u00f4pital Saint-Louis, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Cambau","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Paris, INSERM, IAME, Paris, France"},{"name":"AP-HP, Service de Bact\u00e9riologie-Virologie, H\u00f4pital Lariboisi\u00e8re, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Tenaillon","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Paris, INSERM, IAME, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erick","family":"Denamur","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Paris, INSERM, IAME, Paris, France"},{"name":"AP-HP, Laboratoire de G\u00e9n\u00e9tique Mol\u00e9culaire, H\u00f4pital Bichat, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9atrice","family":"Ber\u00e7ot","sequence":"first","affiliation":[{"name":"AP-HP, Service de Microbiologie, H\u00f4pital Saint-Louis, Paris, France"},{"name":"Universit\u00e9 de Paris, INSERM, IAME, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the IAME Resistance 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