{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:22:11Z","timestamp":1787170931205,"version":"build-2736575974"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T00:00:00Z","timestamp":1586995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National Major Scientific and Technological Special Project","award":["2017ZX10202101-003"],"award-info":[{"award-number":["2017ZX10202101-003"]}]},{"name":"National Major Scientific and Technological Special Project","award":["2017ZX10202203"],"award-info":[{"award-number":["2017ZX10202203"]}]},{"name":"Joint-Innovative Program in Healthcare for Special Scientific Research Projects of Guangzhou","award":["201803040002"],"award-info":[{"award-number":["201803040002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>HIV-1 acquired drug resistance (ADR) has become a critical clinical and public health issue. Recently, HIV-1 CRF55_01B has been found more frequently in the MSM population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the characteristics of HIV-1 drug resistance mutations (DRMs) and the extent of changes in drug susceptibility among ART-experienced CRF55_01B-infected adults of Guangdong.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>ADR was tested for immediately in CRF55_01B-infected patients with virological failure. Demographic and epidemiological information was collected. DRMs and antiretroviral susceptibility were interpreted using the Stanford University HIV Drug Resistance Database HIVdb program.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 162 (4.78%) CRF55_01B isolates were identified from 2013 to 2018. Among DRMs, M184V (43.83%) was the most frequent NRTI DRM, followed by K65R (23.46%), and V179E (98.77%) was the most frequent NNRTI DRM, followed by K103N (47.53%) and Y181C (14.81%). According to the HIVdb program, 79.01% of the CRF55_01B-infected patients carried mutations conferring low-level or higher drug resistance to any of the three classes of ART drugs. Among PI DRMs, only one mutation affording low-level resistance to nelfinavir was found (0.62%). Among NRTI DRMs, a high proportion of high-level resistance to lamivudine (58.64%) and emtricitabine (58.02%) was found. As regards NNRTIs, more than 75% of patients carried efavirenz and nevirapine DRMs. The percentages of high-level resistance were 70.99%, 63.58%, 22.22%, 17.90% and 4.32% for nevirapine, efavirenz, rilpivirine, doravirine and etravirine, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>High frequencies of DRMs and resistance were observed among CRF55_01B-infected patients failing ART in Guangdong, and interventions may be considered to minimize ecological contributions to ART.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jac\/dkaa116","type":"journal-article","created":{"date-parts":[[2020,3,7]],"date-time":"2020-03-07T07:28:23Z","timestamp":1583566103000},"page":"1925-1931","source":"Crossref","is-referenced-by-count":12,"title":["Characteristics of drug resistance in HIV-1 CRF55_01B from ART-experienced patients in Guangdong, China"],"prefix":"10.1093","volume":"75","author":[{"given":"Yun","family":"Lan","sequence":"first","affiliation":[{"name":"Infectious Disease Institute of Guangzhou Eighth People\u2019s Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruolei","family":"Xin","sequence":"first","affiliation":[{"name":"Institute of AIDS\/STD Prevention and Control, Beijing Center for Disease Prevention and Control, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Cai","sequence":"first","affiliation":[{"name":"Infectious Disease Center of Guangzhou Eighth People\u2019s Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xizi","family":"Deng","sequence":"first","affiliation":[{"name":"Infectious Disease Institute of Guangzhou Eighth People\u2019s Hospital, Guangzhou Medical University, 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