{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:10:45Z","timestamp":1790687445319,"version":"4.1.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"French health authorities"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To describe the implementation and use of a computerized decision support system (CDSS) for antibiotic prescription in primary care in France (Antibioclic). The CDSS targets 37 infectious diseases and has been freely available on a website since 2011.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Description and implementation of the architecture of a CDSS for antibiotic prescription in general practice. Analysis of the queries made between 2012 and 2018 on the CDSS by GPs. Analysis of two cross-sectional studies of users in 2014 and 2019.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The number of queries increased from a median of 796\/day [IQR, 578\u2013989] in 2012 to 11\u2009125\/day [5592\u201312\u2009505] in 2018. Unique users increased from 414\/day [245\u2013494] in 2012 to 5365\/day [2891\u20135769] in 2018. Time taken to make a query was 2\u2009min [1.9\u20132.1]. Among 3\u2009542\u2009347 queries in 2018, 78% were for adults. Six situations accounted for \u226550% of queries: cystitis; acute otitis media; acute sinusitis; community-acquired pneumonia; sore throat; and pyelonephritis. Queries concerned pathologies for which antibiotic prescription was necessary (64%), was conditional on additional clinical steps (34%) or was not recommended (2%). Most users (81%) were GPs, with median age of 38\u2009years [31\u201352] and 58% were female. Among the 4016 GPs who responded to the surveys, the vast majority (96%) reported using the CDSS during the consultation, with 24% systematically using Antibioclic to initiate an antibiotic course and 93% having followed the CDSS recommendation for the latest prescription. Most GPs were comfortable using the CDSS in front of a patient.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Antibioclic has been adopted and is widely used in primary care in France. Its interoperability could allow its adaptation and implementation in other countries.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkaa167","type":"journal-article","created":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T19:13:29Z","timestamp":1586805209000},"source":"Crossref","is-referenced-by-count":15,"title":["A computerized decision support system (CDSS) for antibiotic prescription in primary care\u2014Antibioclic: implementation, adoption and sustainable use in the era of extended antimicrobial resistance"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0165-8934","authenticated-orcid":false,"given":"Tristan","family":"Delory","sequence":"first","affiliation":[{"name":"Antibioclic steering committee, Paris, France"},{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d\u2019\u00c9pid\u00e9miologie et de Sant\u00e9 Publique, IPLESP, F75012 Paris, France"},{"name":"AP-HP, Bichat hospital, Department of Infectious and Tropical Diseases, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Jeanmougin","sequence":"first","affiliation":[{"name":"Antibioclic steering committee, Paris, France"},{"name":"Department of General Practice, Faculty of Medicine, University of Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Lariven","sequence":"first","affiliation":[{"name":"Antibioclic steering committee, Paris, France"},{"name":"AP-HP, Bichat hospital, Department of Infectious and Tropical Diseases, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Aubert","sequence":"first","affiliation":[{"name":"Antibioclic steering committee, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Peiffer-Smadja","sequence":"first","affiliation":[{"name":"AP-HP, Bichat hospital, Department of Infectious and Tropical Diseases, Paris, France"},{"name":"UMR 1137, INSERM, IAME, Paris, France"},{"name":"Paris Diderot University Paris 7, Sorbonne Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Yves","family":"Bo\u00eblle","sequence":"first","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d\u2019\u00c9pid\u00e9miologie et de Sant\u00e9 Publique, IPLESP, F75012 Paris, France"},{"name":"AP-HP, Saint Antoine hospital, Public Health unit, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Bouvet","sequence":"first","affiliation":[{"name":"Antibioclic steering committee, Paris, France"},{"name":"AP-HP, Bichat hospital, Department of Infectious and Tropical Diseases, Paris, France"},{"name":"Paris Diderot University Paris 7, Sorbonne Paris Cit\u00e9, Paris, France"},{"name":"French National Authority for Health (HAS), Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois-Xavier","family":"Lescure","sequence":"first","affiliation":[{"name":"Antibioclic steering committee, Paris, France"},{"name":"AP-HP, Bichat hospital, Department of Infectious and Tropical Diseases, Paris, France"},{"name":"UMR 1137, INSERM, IAME, Paris, France"},{"name":"Paris Diderot University Paris 7, Sorbonne Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josselin","family":"Le Bel","sequence":"first","affiliation":[{"name":"Antibioclic steering committee, Paris, France"},{"name":"UMR 1137, INSERM, IAME, Paris, France"},{"name":"Department of General Practice, Universit\u00e9 Paris Diderot, Universit\u00e9 de Paris, Sorbonne Paris Cit\u00e9, 75018 Paris, 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