{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:54:20Z","timestamp":1789674860018,"version":"4.0.1"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T00:00:00Z","timestamp":1593129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Everest Medicines (US) Co., Ltd."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>SPR206 is a novel polymyxin analogue. Activity against clinical isolates is little\u00a0documented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A collection of 200 MDR, carbapenem-resistant, tigecycline-resistant, colistin-resistant and non-MDR clinical isolates of Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, Enterobacter cloacae and Stenotrophomonas maltophilia was obtained from 50 centres across China (2016\u201317). All isolates were derived from respiratory tract, urine and blood samples. Strains were purposely selected on the basis of phenotypes, genotypes and specimen origins. MICs of SPR206 and other antimicrobials were determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>SPR206 was active against all bacteria tested except colistin-resistant isolates. The MIC50\/90 values of SPR206 for colistin-resistant strains were comparable to known polymyxins (16\/128 versus 8\/128\u2009mg\/L). SPR206 exhibited potent activity against colistin-susceptible OXA-producing A. baumannii (MIC50\/90\u2009=\u20090.064\/0.125\u2009mg\/L), NDM-producing Enterobacteriaceae (MIC50\/90\u2009=\u20090.125\/0.25\u2009mg\/L) and KPC-2-producing Enterobacteriaceae (MIC50\/90\u2009=\u20090.125\/0.5\u2009mg\/L). In fact, SPR206 was the most potent agent tested, with 2- to 4-fold lower MICs than colistin and polymyxin B for A. baumannii, P. aeruginosa and Enterobacteriaceae. Additionally, MIC values of SPR206 (MIC50\/90\u2009=\u20090.064\/0.125\u2009mg\/L) were 16- to 32-fold lower than those of tigecycline (MIC50\/90\u2009=\u20092\/2\u2009mg\/L) for tigecycline-susceptible carbapenem-resistant A. baumannii.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SPR206 showed good in vitro activity against MDR, tigecycline-resistant and non-MDR clinical isolates of Gram-negative pathogens. SPR206 also exhibited superior potency to colistin and polymyxin B, with 2- to 4-fold lower MIC50\/90 values.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jac\/dkaa217","type":"journal-article","created":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T15:10:49Z","timestamp":1588777849000},"page":"2609-2615","source":"Crossref","is-referenced-by-count":50,"title":["Evaluation of the in vitro activity of new polymyxin B analogue SPR206 against clinical MDR, colistin-resistant and tigecycline-resistant Gram-negative bacilli"],"prefix":"10.1093","volume":"75","author":[{"given":"Yawei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Peking University People\u2019s Hospital, Beijing 100044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunjiang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Peking University People\u2019s Hospital, Beijing 100044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Peking University People\u2019s Hospital, Beijing 100044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Peking University People\u2019s Hospital, Beijing 100044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Peking University People\u2019s Hospital, Beijing 100044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Peking University People\u2019s Hospital, Beijing 100044, 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