{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:03:37Z","timestamp":1790388217040,"version":"4.1.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2020,7,25]],"date-time":"2020-07-25T00:00:00Z","timestamp":1595635200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100012619","name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fragilidad y Envejecimiento Saludable","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012619","name":"CIBERFES","doi-asserted-by":"publisher","award":["CB16\/10\/00245"],"award-info":[{"award-number":["CB16\/10\/00245"]}],"id":[{"id":"10.13039\/100012619","id-type":"DOI","asserted-by":"publisher"}]},{"name":"FIS Project from Instituto de Salud Carlos III"},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PI13\/00589"],"award-info":[{"award-number":["PI13\/00589"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PI16\/01860"],"award-info":[{"award-number":["PI16\/01860"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002924","name":"FEDER","doi-asserted-by":"publisher","award":["K24 AI120834"],"award-info":[{"award-number":["K24 AI120834"]}],"id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Bone mineral density (BMD) decreases with ART initiation with a tenofovir disoproxil fumarate-containing regimen, although bone tissue quality increases. The impact of dolutegravir (DTG)\/abacavir (ABC)\/lamivudine (3TC)-based ART initiation on bone health parameters is not clear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To study the impact of DTG\/ABC\/3TC-based therapy on bone health parameters in ART-naive individuals with HIV after 48\u2009weeks of treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>An observational, prospective and analytical study of treatment-naive patients with HIV undergoing a DTG\/ABC\/3TC-based regimen at 48\u2009week follow-up. Changes in bone strength parameters (BMD, bone microarchitecture and bone tissue quality) were assessed with non-parametric methods.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Sixteen HIV-infected ART-naive patients starting DTG\/ABC\/3TC were included. BMD in the lumbar spine showed a significant decrease of \u22122.25% (P\u2009=\u20090.007) and \u22124.1% in the femoral neck (P\u2009=\u20090.007). Bone microarchitecture, as measured by trabecular bone score, also decreased significantly by \u22122.5% (P\u2009=\u20090.03). In contrast, bone quality [bone material strength index (BMi)], as measured by microindentation, significantly increased with respect to baseline after 48\u2009weeks of treatment, showing better bone properties of +6.53% (P\u2009&amp;lt;\u20090.001). No significant changes were found in bone turnover markers. In addition, a positive significant correlation between the CD4\/CD8 cell count ratio at baseline and changes in BMSi after 48\u2009weeks of treatment was observed (Spearman\u2019s rho\u2009=\u20090.4974; P\u2009=\u20090.04).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>After a 48\u2009week treatment with DTG\/ABC\/3TC-based ART, BMD and trabecular bone score decreased while bone tissue quality, as measured by microindentation, improved significantly. The state of the immune system at ART initiation is related to bone quality recovery. An overarching approach to assess bone toxicity in ART-treated patients is needed.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkaa254","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T19:23:20Z","timestamp":1595273000000},"page":"2998-3003","source":"Crossref","is-referenced-by-count":10,"title":["Bone density, microarchitecture and tissue quality after 1 year of treatment with dolutegravir\/abacavir\/lamivudine"],"prefix":"10.1093","volume":"75","author":[{"given":"Jade","family":"Soldado-Folgado","sequence":"first","affiliation":[{"name":"Infectious Diseases Department, Hospital del Mar, Barcelona, Spain"},{"name":"Departament de Medicina, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Lerma-Chippirraz","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Hospital del Mar, Barcelona, 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Mar Medical Research Institute), Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Fragilidad y Envejecimiento Saludable (CIBERFES), ISCIII, Barcelona, Catalonia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Trenchs-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"ABS Passeig de Sant Joan, Institut Catal\u00e0 de la Salut, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judit","family":"Villar-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Hospital del Mar, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Gonz\u00e1lez-Mena","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Hospital del Mar, Barcelona, 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