{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T14:56:17Z","timestamp":1779893777815,"version":"3.53.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T00:00:00Z","timestamp":1596153600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Real-world experience regarding the effectiveness of co-formulated elvitegravir, cobicistat, emtricitabine and tenofovir alafenamide (EVG\/C\/FTC\/TAF) as a switch regimen is sparse among people living with HIV (PLWH) harbouring the M184V\/I mutation with or without thymidine analogue-associated mutations (TAMs).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this retrospective multicentre study, PLWH who were switched to EVG\/C\/FTC\/TAF after having achieved viral suppression (plasma HIV RNA &amp;lt;200\u2009copies\/mL) for 6\u2009months or longer were included. Patients with archived M184V\/I mutation (case patients) were matched to controls without M184V\/I mutation at a 1:4 ratio. Patients with a history of virological failure or resistance to elvitegravir were excluded. The primary endpoint was virological non-success (plasma HIV RNA \u226550\u2009copies\/mL) at Week 48 of switch using a modified FDA snapshot analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Overall, 100 case patients with the M184V\/I mutation were identified, including 6 (6.0%) with K65R and 13 (13.0%) with at least one TAM, and were matched to 400 controls in terms of gender, age (mean\u2009=\u200940.3 versus 39.7\u2009years) and cumulative exposure duration to tenofovir disoproxil fumarate (median\u2009=\u2009146 versus 143\u2009weeks). At Week 48, the rate of virological non-success for the case patients and controls was 5.0% (5\/100) and 3.3% (13\/400), respectively (difference\u2009=\u20091.7%; 95% CI\u2009=\u2009\u22122.9%\u20136.3%), while the rate of virological success was 88.0% and 89.5% for the case patients and controls, respectively. The presence of the K65R mutation or TAMs was not associated with virological non-response.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Among virally suppressed PLWH, EVG\/C\/FTC\/TAF is effective in maintaining viral suppression at Week 48 despite archived M184V\/I mutation with or without TAMs.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkaa287","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T19:10:32Z","timestamp":1592248232000},"page":"2986-2993","source":"Crossref","is-referenced-by-count":8,"title":["Impact of archived M184V\/I mutation on the effectiveness of switch to co-formulated elvitegravir, cobicistat, emtricitabine and tenofovir alafenamide among virally suppressed people living with HIV"],"prefix":"10.1093","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1310-4648","authenticated-orcid":false,"given":"Guan-Jhou","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin County, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Lin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Changhua Christian Hospital, Changhua County, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Hsiang","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Yun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Yu","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan"},{"name":"School of Public Health, National Yang-Ming University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung-Chin","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan"},{"name":"School of Medicine, National Yang-Ming University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Hsi","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan"},{"name":"Department of 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