{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:35:22Z","timestamp":1790562922415,"version":"4.1.0"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T00:00:00Z","timestamp":1614729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Nikkomycin Z is a competitive inhibitor of chitin synthase\u2014an enzyme needed for synthesis of the fungal cell wall. Nikkomycin Z shows promise as a treatment for coccidioidomycoses and mixed activity has been described against other fungi and yeast. To our knowledge, it has not previously been tested against the emerging fungal pathogen Candida auris.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To determine the in vitro activity of nikkomycin Z against C. auris.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Nikkomycin Z was tested by broth microdilution against a panel of 100 isolates of genetically diverse C. auris from around the world.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Nikkomycin Z showed mixed activity against the tested isolates, with an MIC range of 0.125 to &amp;gt;64\u2009mg\/L. The MIC50 and MIC90 were 2 and 32\u2009mg\/L, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>These findings suggest nikkomycin Z has in vitro activity against some, but not all isolates of C. auris.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkab052","type":"journal-article","created":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T12:43:36Z","timestamp":1612874616000},"page":"1495-1497","source":"Crossref","is-referenced-by-count":28,"title":["Antifungal activity of nikkomycin Z against <i>Candida auris<\/i>"],"prefix":"10.1093","volume":"76","author":[{"given":"Meghan L","family":"Bentz","sequence":"first","affiliation":[{"name":"Mycotic Diseases Branch, Centers for Disease Control and Prevention, 1600 Clifton Rd., Mailstop H17-2, Atlanta, GA30333, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Nunnally","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn R","family":"Lockhart","sequence":"additional","affiliation":[{"name":"Mycotic Diseases Branch, Centers for Disease Control and Prevention, 1600 Clifton Rd., Mailstop H17-2, Atlanta, GA30333, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D Joseph","family":"Sexton","sequence":"additional","affiliation":[{"name":"Mycotic Diseases Branch, Centers for Disease Control and Prevention, 1600 Clifton Rd., Mailstop H17-2, Atlanta, GA30333, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth L","family":"Berkow","sequence":"additional","affiliation":[{"name":"Mycotic Diseases Branch, Centers for Disease Control and Prevention, 1600 Clifton Rd., Mailstop H17-2, Atlanta, GA30333, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,3,3]]},"reference":[{"key":"2021051408573510000_dkab052-B1","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1128\/AAC.36.9.1909","article-title":"Chitin biosynthesis in Candida albicans grown in vitro and in vivo and its inhibition by nikkomycin Z","volume":"36","author":"Chapman","year":"1992","journal-title":"Antimicrob Agents Chemother"},{"key":"2021051408573510000_dkab052-B2","doi-asserted-by":"crossref","first-page":"261.","DOI":"10.3390\/jof6040261","article-title":"Nikkomycin Z\u2014ready to meet the promise?","volume":"6","author":"Larwood","year":"2020","journal-title":"J Fungi"},{"key":"2021051408573510000_dkab052-B3","doi-asserted-by":"crossref","first-page":"747","DOI":"10.3109\/13693786.2013.770610","article-title":"Efficacy of nikkomycin Z for respiratory coccidioidomycosis in naturally infected dogs","volume":"51","author":"Shubitz","year":"2013","journal-title":"Med Mycol"},{"key":"2021051408573510000_dkab052-B4","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1128\/AAC.43.6.1401","article-title":"In vitro antifungal activity of nikkomycin Z in combination with fluconazole or itraconazole","volume":"43","author":"Li","year":"1999","journal-title":"Antimicrob Agents Chemother"},{"key":"2021051408573510000_dkab052-B5","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1093\/jac\/dkn216","article-title":"Antifungal activity against Candida albicans of nikkomycin Z in combination with caspofungin, voriconazole or amphotericin B","volume":"62","author":"Sandovsky-Losica","year":"2008","journal-title":"J Antimicrob Chemother"},{"key":"2021051408573510000_dkab052-B6"},{"key":"2021051408573510000_dkab052-B7","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1093\/cid\/ciw691","article-title":"Simultaneous emergence of multidrug-resistant Candida auris on 3 continents confirmed by whole-genome sequencing and epidemiological analyses","volume":"64","author":"Lockhart","year":"2017","journal-title":"Clin Infect Dis"},{"key":"2021051408573510000_dkab052-B8","year":"2017"},{"key":"2021051408573510000_dkab052-B9","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1128\/JCM.00932-16","article-title":"Verification of an automated, digital dispensing platform for At-Will Broth microdilution-based antimicrobial susceptibility testing","volume":"54","author":"Smith","year":"2016","journal-title":"J Clin Microbiol"}],"container-title":["Journal of Antimicrobial 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