{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T01:58:17Z","timestamp":1773712697550,"version":"3.50.1"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T00:00:00Z","timestamp":1621468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fondo de Investigaciones Sanitarias","award":["INT15\/0186"],"award-info":[{"award-number":["INT15\/0186"]}]},{"name":"Fondo de Investigaciones Sanitarias","award":["INT16\/0117"],"award-info":[{"award-number":["INT16\/0117"]}]},{"name":"Fondo de Investigaciones Sanitarias","award":["PI18\/00339"],"award-info":[{"award-number":["PI18\/00339"]}]},{"name":"CIBER de Enfermedades Respiratorias","award":["CIBERES\u2014CB06\/06\/0037"],"award-info":[{"award-number":["CIBERES\u2014CB06\/06\/0037"]}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004895","name":"European Social Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To phenotypically and genetically characterize the antibiotic resistance determinants and associated mobile genetic elements (MGEs) among macrolide-resistant (MR) Streptococcus pyogenes [Group A streptococci (GAS)] clinical isolates collected in Barcelona, Spain.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Antibiotic susceptibility testing was performed by microdilution. Isolates were emm and MLST typed and 55 were whole-genome sequenced to determine the nature of the macrolide resistance (MR) determinants and their larger MGE and chromosomal context.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Between 1998 and 2018, 142 of 1028 GAS (13.8%) were MR. Among 108 isolates available for molecular characterization, 41.7% had cMLSB, 30.5% iMLSB and 27.8% M phenotype. Eight erm(B)-containing strains were notable in having an MDR phenotype conferred by an MGE encoding several antibiotic resistance genes. MR isolates were comprised of several distinct genetic lineages as defined by the combination of emm and ST. Although most lineages were only transiently present, the emm11\/ST403 clone persisted throughout the period. Two lineages, emm9\/ST75 with erm(B) and emm77\/ST63 with erm(TR), emerged in 2016\u201318. The erm(B) was predominantly encoded on the Tn916 family of transposons (21\/31) with different genetic contexts, and in other MGEs (Tn6263, ICESpHKU372 and one harbouring an MDR cluster called ICESp1070HUB). The erm(TR) was found in ICESp2905 (8\/17), ICESp1108-like (4\/17), ICESpHKU165 (3\/17) and two structures described in this study (IMESp316HUB and ICESp3729HUB). The M phenotype [mef(A)-msr(D)] was linked to phage \u03c61207.3. Eight integrative conjugative element\/integrative mobilizable element (ICE\/IME) cluster groups were classified on the basis of gene content within conjugation modules. These groups were found among MGEs, which corresponded with the MR-containing element or the site of integration.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We detected several different MGEs harbouring erm(B) or erm(TR). This is the first known description of Tn6263 in GAS and three MGEs [IMESp316HUB, ICESp3729HUB and ICESp1070HUB] associated with MR. Periods of high MR rates in our area were mainly associated with the expansion of certain predominant lineages, while in low MR periods different sporadic and low prevalence lineages were more frequent.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkab130","type":"journal-article","created":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T19:43:48Z","timestamp":1617824628000},"page":"1991-2003","source":"Crossref","is-referenced-by-count":27,"title":["Deciphering mobile genetic elements disseminating macrolide resistance in <i>Streptococcus pyogenes<\/i> over a 21 year period in Barcelona, Spain"],"prefix":"10.1093","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3689-3360","authenticated-orcid":false,"given":"D\u00e0maris","family":"Berbel","sequence":"first","affiliation":[{"name":"Microbiology Department, Hospital Universitari de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain"},{"name":"CIBER de Enfermedades Respiratorias, ISCIII, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0817-0931","authenticated-orcid":false,"given":"Jordi","family":"C\u00e0mara","sequence":"additional","affiliation":[{"name":"Microbiology Department, Hospital Universitari de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain"},{"name":"CIBER de Enfermedades Respiratorias, ISCIII, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aida","family":"Gonz\u00e1lez-D\u00edaz","sequence":"additional","affiliation":[{"name":"Microbiology Department, Hospital Universitari de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain"},{"name":"CIBER de Enfermedades Respiratorias, ISCIII, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meritxell","family":"Cubero","sequence":"additional","affiliation":[{"name":"Microbiology Department, Hospital Universitari de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain"},{"name":"CIBER de Enfermedades Respiratorias, ISCIII, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillem","family":"L\u00f3pez de Egea","sequence":"additional","affiliation":[{"name":"Microbiology Department, Hospital Universitari de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0405-2305","authenticated-orcid":false,"given":"Sara","family":"Mart\u00ed","sequence":"additional","affiliation":[{"name":"Microbiology Department, Hospital Universitari de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain"},{"name":"CIBER de Enfermedades Respiratorias, ISCIII, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fe","family":"Tubau","sequence":"additional","affiliation":[{"name":"Microbiology Department, Hospital Universitari de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain"},{"name":"CIBER de Enfermedades Respiratorias, ISCIII, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M Angeles","family":"Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Microbiology Department, Hospital Universitari de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain"},{"name":"Departament of Pathology and Experimental Therapeutics, University of Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0225-607X","authenticated-orcid":false,"given":"Carmen","family":"Ardanuy","sequence":"additional","affiliation":[{"name":"Microbiology Department, Hospital Universitari de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain"},{"name":"CIBER de Enfermedades Respiratorias, ISCIII, Madrid, Spain"},{"name":"Departament of Pathology and Experimental Therapeutics, University of Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,5,20]]},"reference":[{"key":"2021071609141351800_dkab130-B1","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1128\/CMR.00101-13","article-title":"Disease manifestations and pathogenic mechanisms of group A Streptococcus","volume":"27","author":"Walker","year":"2014","journal-title":"Clin Microbiol Rev"},{"key":"2021071609141351800_dkab130-B2","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1128\/AAC.40.8.1817","article-title":"Streptococcus pneumoniae and Streptococcus pyogenes resistant to macrolides but sensitive to clindamycin: a common resistance pattern mediated by an efflux system","volume":"40","author":"Sutcliffe","year":"1996","journal-title":"Antimicrob Agents Chemother"},{"key":"2021071609141351800_dkab130-B3","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1093\/jac\/dkf038","article-title":"Resistance to macrolides in clinical isolates of Streptococcus pyogenes due to ribosomal mutations","volume":"49","author":"Malbruny","year":"2002","journal-title":"J Antimicrob Chemother"},{"key":"2021071609141351800_dkab130-B4","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1128\/AAC.00781-08","article-title":"Genetic elements responsible for erythromycin resistance in Streptococci","volume":"53","author":"Varaldo","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"2021071609141351800_dkab130-B5","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1128\/AAC.01378-10","article-title":"Two distinct genetic elements are responsible for erm(TR)-mediated erythromycin resistance in tetracycline-susceptible and tetracycline-resistant strains of Streptococcus pyogenes","volume":"55","author":"Brenciani","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"2021071609141351800_dkab130-B6","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.1128\/AAC.01494-12","article-title":"ICESp1116, the genetic element responsible for erm(B)-mediated, inducible erythromycin resistance in Streptococcus pyogenes","volume":"56","author":"Brenciani","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"2021071609141351800_dkab130-B7","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/ng.3147","article-title":"Emergence of scarlet fever Streptococcus pyogenes emm12 clones in Hong Kong is associated with toxin acquisition and multidrug resistance","volume":"47","author":"Davies","year":"2015","journal-title":"Nat Genet"},{"key":"2021071609141351800_dkab130-B8","first-page":"746","article-title":"Transduction of the Streptococcus pyogenes bacteriophage \u03a6m46.1, carrying resistance genes mef(A) and tet(O), to other Streptococcus species","volume":"5","author":"Giovanetti","year":"2014","journal-title":"Front Microbiol"},{"key":"2021071609141351800_dkab130-B9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2014.00687","article-title":"Nucleotide sequence of conjugative prophage \u03c61207.3 (formerly Tn1207.3) carrying the mef(A)\/msr(D) genes for efflux resistance to macrolides in Streptococcus pyogenes","volume":"5","author":"Iannelli","year":"2014","journal-title":"Front Microbiol"},{"key":"2021071609141351800_dkab130-B10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/microbiolspec.GPP3-0059-2018","article-title":"The bacteriophages of Streptococcus pyogenes","volume":"7","author":"McShan","year":"2019","journal-title":"Microbiol Spectr"},{"key":"2021071609141351800_dkab130-B11","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1128\/AAC.00499-09","article-title":"\u03a6m46.1, the main Streptococcus pyogenes element carrying mef(A) and tet(O) genes","volume":"54","author":"Brenciani","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"2021071609141351800_dkab130-B12","doi-asserted-by":"crossref","first-page":"e800","DOI":"10.1371\/journal.pone.0000800","article-title":"Contribution of exogenous genetic elements to the Group A Streptococcus metagenome","volume":"2","author":"Beres","year":"2007","journal-title":"PLoS One"},{"key":"2021071609141351800_dkab130-B13","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1111\/1574-6976.12058","article-title":"Conjugative and mobilizable genomic islands in bacteria: evolution and diversity","volume":"38","author":"Bellanger","year":"2014","journal-title":"FEMS Microbiol Rev"},{"key":"2021071609141351800_dkab130-B14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2017.00443","article-title":"A glimpse into the world of integrative and mobilizable elements in Streptococci reveals an unexpected diversity and novel families of mobilization proteins","volume":"8","author":"Coluzzi","year":"2017","journal-title":"Front Microbiol"},{"key":"2021071609141351800_dkab130-B15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2015.01483","article-title":"New insights into the classification and integration specificity of Streptococcus integrative conjugative elements through extensive genome exploration","volume":"6","author":"Ambroset","year":"2016","journal-title":"Front Microbiol"},{"key":"2021071609141351800_dkab130-B16","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.plasmid.2013.09.005","article-title":"Conjugative type IV secretion systems in Gram-positive bacteria","volume":"70","author":"Goessweiner-Mohr","year":"2013","journal-title":"Plasmid"},{"key":"2021071609141351800_dkab130-B17","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1093\/jac\/dkq006","article-title":"Molecular characterization of macrolide- and multidrug-resistant Streptococcus pyogenes isolated from adult patients in Barcelona, Spain (1993\u20132008)","volume":"65","author":"Ardanuy","year":"2010","journal-title":"J Antimicrob Chemother"},{"key":"2021071609141351800_dkab130-B18","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1093\/jac\/dkv182","article-title":"Declining macrolide resistance in Streptococcus pyogenes in Portugal (2007\u201313) was accompanied by continuous clonal changes","volume":"70","author":"Silva-Costa","year":"2015","journal-title":"J Antimicrob Chemother"},{"key":"2021071609141351800_dkab130-B19","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.3201\/eid1809.120049","article-title":"Antimicrobial drug use and macrolide-resistant Streptococcus pyogenes, Belgium","volume":"18","author":"Van Heirstraeten","year":"2012","journal-title":"Emerg Infect Dis"},{"key":"2021071609141351800_dkab130-B20","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1093\/jac\/dkw116","article-title":"Molecular analysis of Streptococcus pyogenes macrolide resistance of paediatric isolates during a 7 year period (2007\u201313)","volume":"71","author":"Michos","year":"2016","journal-title":"J Antimicrob Chemother"},{"key":"2021071609141351800_dkab130-B21","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1128\/JCM.00029-14","article-title":"Deriving group A Streptococcus typing information from short-read whole-genome sequencing data","volume":"52","author":"Athey","year":"2014","journal-title":"J Clin Microbiol"},{"key":"2021071609141351800_dkab130-B22","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1093\/jac\/dks261","article-title":"Identification of acquired antimicrobial resistance genes","volume":"67","author":"Zankari","year":"2012","journal-title":"J Antimicrob Chemother"},{"key":"2021071609141351800_dkab130-B23","doi-asserted-by":"crossref","first-page":"D325","DOI":"10.1093\/nar\/gki008","article-title":"VFDB: a reference database for bacterial virulence factors","volume":"33","author":"Chen","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"2021071609141351800_dkab130-B24","doi-asserted-by":"crossref","first-page":"D621","DOI":"10.1093\/nar\/gkr846","article-title":"ICEberg: a web-based resource for integrative and conjugative elements found in bacteria","volume":"40","author":"Bi","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"2021071609141351800_dkab130-B25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13059-014-0524-x","article-title":"The harvest suite for rapid core-genome alignment and visualization of thousands of intraspecific microbial genomes","volume":"15","author":"Treangen","year":"2014","journal-title":"Genome Biol"},{"key":"2021071609141351800_dkab130-B26","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1534\/genetics.105.048975","article-title":"A simple and robust statistical test for detecting the presence of recombination","volume":"172","author":"Bruen","year":"2006","journal-title":"Genetics"},{"key":"2021071609141351800_dkab130-B27","doi-asserted-by":"crossref","first-page":"4658","DOI":"10.1073\/pnas.071559398","article-title":"Complete genome sequence of an M1 strain of Streptococcus pyogenes","volume":"98","author":"Ferretti","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021071609141351800_dkab130-B28","first-page":"e000093","article-title":"Microreact: visualizing and sharing data for genomic epidemiology and phylogeography","volume":"2","author":"Argim\u00f3n","year":"2016","journal-title":"Microb Genom"},{"key":"2021071609141351800_dkab130-B29","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1093\/bioinformatics\/btr039","article-title":"Easyfig: a genome comparison visualizer","volume":"27","author":"Sullivan","year":"2011","journal-title":"Bioinformatics"},{"key":"2021071609141351800_dkab130-B30","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41598-019-54409-2","article-title":"Changes in emm types and superantigen gene content of Streptococcus pyogenes causing invasive infections in Portugal","volume":"9","author":"Fri\u00e3es","year":"2019","journal-title":"Sci Rep"},{"key":"2021071609141351800_dkab130-B31","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jinf.2018.05.010","article-title":"Epidemiology of an upsurge of invasive group A streptococcal infections in Ireland, 2012\u20132015","volume":"77","author":"Meehan","year":"2018","journal-title":"J Infect"},{"key":"2021071609141351800_dkab130-B32","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1099\/jmm.0.000146","article-title":"Evolution of macrolide resistance in Streptococcus pyogenes over 14 years in an area of central Italy","volume":"64","author":"Pozzi","year":"2015","journal-title":"J Med Microbiol"},{"key":"2021071609141351800_dkab130-B33","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1093\/jac\/dku039","article-title":"What causes decreased erythromycin resistance in Streptococcus pyogenes? Dynamics of four clones in a southern European region from 2005 to 2012","volume":"69","author":"Montes","year":"2014","journal-title":"J Antimicrob Chemother"},{"key":"2021071609141351800_dkab130-B34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/mBio.01422-17","article-title":"Population and whole genome sequence based characterization of invasive group A streptococci recovered in the United States during 2015","volume":"8","author":"Chochua","year":"2017","journal-title":"MBio"},{"key":"2021071609141351800_dkab130-B35","doi-asserted-by":"crossref","first-page":"e000316","DOI":"10.1099\/mgen.0.000316","article-title":"Unexpected relationships between frequency of antimicrobial resistance, disease phenotype and emm type in group A Streptococcus","volume":"5","author":"Sanson","year":"2019","journal-title":"Microb Genomics"},{"key":"2021071609141351800_dkab130-B36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2017.01052","article-title":"High prevalence of macrolide-resistance and molecular characterization of Streptococcus pyogenes isolates circulating in China from 2009 to 2016","volume":"8","author":"Lu","year":"2017","journal-title":"Front Microbiol"},{"key":"2021071609141351800_dkab130-B37","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1007\/s10096-016-2704-y","article-title":"Epidemiology of invasive group A streptococcal infections in Norway 2010\u20132014: a retrospective cohort study","volume":"35","author":"Naseer","year":"2016","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"2021071609141351800_dkab130-B38","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.jiac.2016.06.013","article-title":"Molecular epidemiology, antimicrobial susceptibility, and characterization of macrolide-resistant Streptococcus pyogenes in Japan","volume":"22","author":"Tanaka","year":"2016","journal-title":"J Infect Chemother"},{"key":"2021071609141351800_dkab130-B39","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1086\/379897","article-title":"Structure and distribution of an unusual chimeric genetic element encoding macrolide resistance in phylogenetically diverse clones of group A Streptococcus","volume":"188","author":"Banks","year":"2003","journal-title":"J Infect Dis"},{"key":"2021071609141351800_dkab130-B40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2018.01670","article-title":"Type M resistance to macrolides is due to a two-gene efflux transport system of the ATP-binding cassette (ABC) superfamily","volume":"9","author":"Iannelli","year":"2018","journal-title":"Front Microbiol"},{"key":"2021071609141351800_dkab130-B41","doi-asserted-by":"crossref","first-page":"e0137313","DOI":"10.1371\/journal.pone.0137313","article-title":"Antimicrobial susceptibility of invasive Streptococcus pyogenes isolates in Germany during 2003-2013","volume":"10","author":"Im\u00f6hl","year":"2015","journal-title":"PLoS One"},{"key":"2021071609141351800_dkab130-B42","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/jac\/dki327","article-title":"mef(A), mef(E) and a new mef allele in macrolide-resistant Streptococcus spp. isolates from Norway","volume":"56","author":"Sangvik","year":"2005","journal-title":"J Antimicrob Chemother"},{"key":"2021071609141351800_dkab130-B43","doi-asserted-by":"crossref","first-page":"4999","DOI":"10.1128\/AAC.49.12.4999-5006.2005","article-title":"Molecular characterization of pneumococci with efflux-mediated erythromycin resistance and identification of a novel mef gene subclass, mef(I)","volume":"49","author":"Cochetti","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"2021071609141351800_dkab130-B44","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1093\/jac\/dkv408","article-title":"Macrolide resistance gene erm(TR) and erm(TR)-carrying genetic elements in Streptococcus agalactiae: characterization of ICESagTR7, a new composite element containing IMESp2907","volume":"71","author":"Mingoia","year":"2016","journal-title":"J Antimicrob Chemother"},{"key":"2021071609141351800_dkab130-B45","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3389\/fcimb.2016.00118","article-title":"Evolution and diversity of the antimicrobial resistance associated mobilome in Streptococcus suis: a probable mobile genetic elements reservoir for other streptococci","volume":"6","author":"Huang","year":"2016","journal-title":"Front Cell Infect Microbiol"},{"key":"2021071609141351800_dkab130-B46","doi-asserted-by":"crossref","first-page":"5994","DOI":"10.1128\/AAC.01487-12","article-title":"Streptococcus pneumoniae transposon Tn1545\/Tn6003 changes to Tn6002 due to spontaneous excision in circular form of the erm(B)-and aphA3-containing macrolide-aminoglycoside-streptothricin (MAS) element","volume":"56","author":"Palmieri","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"2021071609141351800_dkab130-B47","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/s41588-019-0417-8","article-title":"Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics","volume":"51","author":"Davies","year":"2019","journal-title":"Nat Genet"},{"key":"2021071609141351800_dkab130-B48","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1093\/jac\/dky016","article-title":"Novel Tn916-like elements confer aminoglycoside\/macrolide co-resistance in clinical isolates of Streptococcus gallolyticus ssp. gallolyticus","volume":"73","author":"Kambarev","year":"2018","journal-title":"J Antimicrob Chemother"},{"key":"2021071609141351800_dkab130-B49","doi-asserted-by":"crossref","first-page":"4328","DOI":"10.1128\/JB.00213-07","article-title":"Characterization of a small mobilizable transposon, MTnSag1, in Streptococcus agalactiae","volume":"189","author":"Achard","year":"2007","journal-title":"J Bacteriol"},{"key":"2021071609141351800_dkab130-B50","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.ijantimicag.2019.08.019","article-title":"A novel genomic island harbouring lsa(E) and lnu(B) genes and a defective prophage in a Streptococcus pyogenes isolate resistant to lincosamide, streptogramin A and pleuromutilin antibiotics","volume":"54","author":"Berbel","year":"2019","journal-title":"Int J Antimicrob Agents"},{"key":"2021071609141351800_dkab130-B51","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.plasmid.2017.03.006","article-title":"Annotation of plasmid genes","volume":"91","author":"Thomas","year":"2017","journal-title":"Plasmid"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/76\/8\/1991\/39065479\/dkab130.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/76\/8\/1991\/39065479\/dkab130.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T09:19:28Z","timestamp":1626427168000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article\/76\/8\/1991\/6279207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,20]]},"references-count":51,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,5,20]]},"published-print":{"date-parts":[[2021,7,15]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dkab130","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,8,1]]},"published":{"date-parts":[[2021,5,20]]}}}