{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T11:27:43Z","timestamp":1767007663664,"version":"3.37.3"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2021,5,22]],"date-time":"2021-05-22T00:00:00Z","timestamp":1621641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Ministry of Science, Innovation and Universities of Spain"},{"name":"Miguel Servet Research Contracts","award":["CP18\/00146","CP18\/00111"],"award-info":[{"award-number":["CP18\/00146","CP18\/00111"]}]},{"name":"FSE \u2018El Fondo Social Europeo invierte"},{"name":"R\u00edo Hortega grant from the Instituto de Salud Carlos III","award":["CM19\/00251"],"award-info":[{"award-number":["CM19\/00251"]}]},{"name":"Spanish Ministry of Science, Innovation and Universities of Spain","award":["CD18\/00091"],"award-info":[{"award-number":["CD18\/00091"]}]},{"name":"Servicio Andaluz de Salud de la Junta de Andalucia","award":["B-0037"],"award-info":[{"award-number":["B-0037"]}]},{"name":"Programa de Intensificaci\u00f3n de la Actividad de Investigaci\u00f3n del Servicio Nacional de Salud Carlos III"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Liver stiffness (LS) at sustained viral response (SVR) is strongly associated with a lower incidence of subsequent hepatic events. HIV NNRTIs may have a beneficial impact on fibrogenesis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Our aim was to analyse the influence of NNRTI-based therapy on the change in LS from starting direct-acting antiviral (DAA) therapy to achieving SVR in HIV\/HCV-coinfected patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Three hundred and thirteen HIV\/HCV-coinfected patients who fulfilled the following criteria were included: (i) had achieved SVR with an IFN-free, DAA-including regimen; (ii) LS \u22659.5\u2009kPa before therapy; (iii) LS measurement available at SVR; (iv) seronegative for HBsAg; and (v) ART containing 2 NRTIs plus either 1 NNRTI or 1 integrase inhibitor (INI) or 1\u20132 NRTIs plus 1 PI. LS changes were assessed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Seventy-four patients received NNRTI-based combinations [53 (71.6%) rilpivirine and 16 (21.6%) efavirenz] and 239 patients received other regimens. At baseline, the median (IQR) LS was 16.7\u2009kPa (11.8\u201325.6) in the NNRTI group and 17.3\u2009kPa (11.9\u201327.4) in the non-NNRTI group (P\u2009=\u20090.278). The median (IQR) percentage of LS decrease from baseline to SVR was 35.2% (18.2%\u201352.3%) for NNRTI-based therapy and 29.5% (10%\u201345.9%) for PI- or INI-based therapy (P\u2009=\u20090.018). In multivariate analysis, adjusted for sex, age, HCV genotype, NRTI backbone and propensity score for HIV therapy, NNRTI-based regimen use was associated with a higher LS decrease [\u03b2\u2009=\u200911.088 (95% CI\u2009=\u20091.67\u201320.51); P\u2009=\u20090.021].<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Treatment with NNRTI plus 2 NRTI combinations is associated with a higher LS decline than other ART combinations in HIV\/HCV-coinfected patients receiving DAA-based therapy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkab157","type":"journal-article","created":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T19:11:54Z","timestamp":1620069114000},"page":"2375-2379","source":"Crossref","is-referenced-by-count":6,"title":["Liver stiffness change with HCV cure in HIV-infected patients on non-nucleoside analogues"],"prefix":"10.1093","volume":"76","author":[{"given":"A.","family":"Gonzalez-Serna","sequence":"first","affiliation":[{"name":"Unit of Infectious Diseases and Microbiology, Hospital Universitario de Valme, Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Corma-Gomez","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases and Microbiology, Hospital Universitario de Valme, Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Tellez","sequence":"additional","affiliation":[{"name":"UGC Enfermedades Infecciosas, Hospital Universitario de Puerto Real, Departamento de Medicina, Universidad de C\u00e1diz, C\u00e1diz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Garc\u00eda-Martin","sequence":"additional","affiliation":[{"name":"UGC Unidad Gesti\u00f3n Cl\u00ednica de Microbiolog\u00eda, Hospital Universitario de Puerto Real, C\u00e1diz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5813-6889","authenticated-orcid":false,"given":"A.","family":"Rivero-Juarez","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, Hospital Universitario Reina Sofia, Instituto Maimonides de Investigaci\u00f3n Biomedica de C\u00f3rdoba (IMIBIC), Universidad de C\u00f3rdoba (UCO), C\u00f3rdoba, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Frias","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, Hospital Universitario Reina Sofia, Instituto Maimonides de Investigaci\u00f3n Biomedica de C\u00f3rdoba (IMIBIC), Universidad de C\u00f3rdoba (UCO), C\u00f3rdoba, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. J.","family":"Vera-M\u00e9ndez","sequence":"additional","affiliation":[{"name":"Hospital General Universitario Santa Luc\u00eda, Cartagena, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"De los Santos","sequence":"additional","affiliation":[{"name":"Unit of Internal Medicine and Infectious Diseases, Hospital La Princesa, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Merino","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, Hospital Juan Ram\u00f3n Jim\u00e9nez, Huelva, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Morano","sequence":"additional","affiliation":[{"name":"Unit of Infectious Pathology, Hospital Universitario Alvaro Cunqueiro, Vigo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Imaz","sequence":"additional","affiliation":[{"name":"HIV and STI Unit, Department of Infectious Diseases, Hospital Universitario de Bellvitge-IDIBELL, L\u2019Hospitalet de Llobregat, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Galera","sequence":"additional","affiliation":[{"name":"HIV and STI Unit, Internal Medicine Department, Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Serrano","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Gran Canaria Dr Negrin, Las Palmas, Gran Canaria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4778-790X","authenticated-orcid":false,"given":"J.","family":"Macias","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases and Microbiology, Hospital Universitario de Valme, Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3751-0296","authenticated-orcid":false,"given":"J. 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