{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T14:49:47Z","timestamp":1789397387974,"version":"build-2803163510"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2021,6,13]],"date-time":"2021-06-13T00:00:00Z","timestamp":1623542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Helperby Therapeutics Group Ltd"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the efficacy of zidovudine in combination with carbapenems against NDM-1-producing Enterobacteriaceae.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>MICs were determined using the broth microdilution method. The combinatory effects of zidovudine and carbapenems were examined using the chequerboard method and time\u2013kill analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that the NDM-1-producing strains were resistant to all carbapenems tested. FIC index from chequerboard assay demonstrated that zidovudine synergized with carbapenems against all the NDM-1 strains. Time\u2013kill analysis demonstrated significant synergistic activity when a low level of zidovudine was combined with meropenem.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Zidovudine in combination with carbapenems produced synergistic activity against NDM-1 Enterobacteriaceae strains in vitro.<\/jats:p><\/jats:sec>","DOI":"10.1093\/jac\/dkab184","type":"journal-article","created":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T19:28:48Z","timestamp":1620674928000},"page":"2302-2305","source":"Crossref","is-referenced-by-count":8,"title":["Zidovudine enhances activity of carbapenems against NDM-1-producing Enterobacteriaceae"],"prefix":"10.1093","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0630-5342","authenticated-orcid":false,"given":"Yanmin","family":"Hu","sequence":"first","affiliation":[{"name":"Institute for Infection and Immunity, St George\u2019s University of London, London, 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