{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:23:49Z","timestamp":1787009029816,"version":"build-2736575974"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T00:00:00Z","timestamp":1625875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"crossref","award":["SAF2016-76571-R"],"award-info":[{"award-number":["SAF2016-76571-R"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"crossref","award":["PID2019-106158RB-I00"],"award-info":[{"award-number":["PID2019-106158RB-I00"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fondo Europeo de Desarrollo Regional (FEDER) of the EU"},{"name":"Enfermedades Infecciosas del Norte"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine the prevalence of penicillin susceptibility among MSSA causing bloodstream infections (BSIs) in 16 Spanish hospitals and to characterize the penicillin-susceptible MSSA (MSSA-PENS) isolates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 1011 Staphylococcus aureus isolates were collected from blood cultures in 16 Spanish hospitals during 2018\u201319 (6\u201312\u2009months) and their susceptibility to 18 antimicrobials was determined. The MSSA-PENS isolates were selected and examined by PCR to determine the presence of the blaZ gene, other resistance genes and the genes lukF\/lukS-PV, eta, etb and tst. The immune evasion cluster (IEC) type was also analysed. All the MSSA-PENS isolates were submitted to S. aureus protein A (spa) typing and the clonal complexes (CCs) were assigned according to their spa type.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The prevalence of MSSA was 74.6% (754\/1011) and 14.9% (151\/1011) were MSSA-PENS-blaZnegative. MSSA-PENS-blaZnegative isolates (n\u2009=\u2009151) were ascribed to 88 spa types and 11 CCs. The most frequent CCs were CC5 (35\/151) and CC398 (25\/151), with t002-CC5 and t571-CC398 being the most common lineages. Pan-susceptibility was identified in 117 of the 151 MSSA-PENS-blaZnegative isolates (77.5%). In the remaining isolates, erythromycin and clindamycin resistance was the most frequent resistance found, although tobramycin, ciprofloxacin, fusidic acid, mupirocin and\/or tetracycline resistance was also detected. Thirty-eight MSSA-PENS-blaZnegative isolates were IEC negative and four isolates were Panton\u2013Valentine leucocidin (\u2018PVL\u2019) positive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A high penicillin susceptibility rate was detected among MSSA, opening therapeutic opportunities for BSIs. The emergence of new successful MSSA-PENS clones could be responsible for these data. The detection among MSSA-PENS-blaZnegative isolates of the clonal lineage CC398 or the absence of an IEC raises questions about their possible animal origin, requiring further analysis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jac\/dkab208","type":"journal-article","created":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T15:23:11Z","timestamp":1622647391000},"page":"2519-2527","source":"Crossref","is-referenced-by-count":20,"title":["Penicillin susceptibility among invasive MSSA infections: a multicentre study in 16 Spanish hospitals"],"prefix":"10.1093","volume":"76","author":[{"given":"Olouwafemi Mistourath","family":"Mama","sequence":"first","affiliation":[{"name":"\u00c1rea Bioqu\u00edmica y Biolog\u00eda Molecular, Universidad de La Rioja, Madre de Dios 53, 26006, Logro\u00f1o, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Aspiroz","sequence":"additional","affiliation":[{"name":"Servicio Microbiolog\u00eda, Hospital 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