{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T12:41:10Z","timestamp":1761396070143},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"Supplement_3","license":[{"start":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T00:00:00Z","timestamp":1632355200000},"content-version":"vor","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,23]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) claimed over 4 million lives by July 2021 and continues to pose a serious public health threat.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Our retrospective study utilized respiratory pathogen panel (RPP) results in patients with SARS-CoV-2 to determine if coinfection (i.e. SARS-CoV-2 positivity with an additional respiratory virus) was associated with more severe presentation and outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients with negative influenza\/respiratory syncytial virus testing who underwent RPP testing within 7\u2009days of a positive SARS-CoV-2 test at a large, academic medical centre in New York were examined. Patients positive for SARS-CoV-2 with a negative RPP were compared with patients positive for SARS-CoV-2 and positive for a virus by RPP in terms of biomarkers, oxygen requirements and severe COVID-19 outcome, as defined by mechanical ventilation or death within 30\u2009days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 306 SARS-CoV-2-positive patients with RPP testing, 14 (4.6%) were positive for a non-influenza virus (coinfected). Compared with the coinfected group, patients positive for SARS-CoV-2 with a negative RPP had higher inflammatory markers and were significantly more likely to be admitted (P\u200a=\u200a0.01). Severe COVID-19 outcome occurred in 111 (36.3%) patients in the SARS-CoV-2-only group and 3 (21.4%) patients in the coinfected group (P\u200a=\u200a0.24).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients infected with SARS-CoV-2 along with a non-influenza respiratory virus had less severe disease on presentation and were more likely to be admitted\u2014but did not have more severe outcomes\u2014than those infected with SARS-CoV-2 alone.<\/jats:p><\/jats:sec>","DOI":"10.1093\/jac\/dkab244","type":"journal-article","created":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T19:13:16Z","timestamp":1625771596000},"page":"iii12-iii19","source":"Crossref","is-referenced-by-count":16,"title":["SARS-CoV-2 coinfection with additional respiratory virus does not predict severe disease: a retrospective cohort study"],"prefix":"10.1093","volume":"76","author":[{"given":"Sweta","family":"Chekuri","sequence":"first","affiliation":[{"name":"Albert Einstein College 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USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumeet","family":"Singh-Tan","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA"},{"name":"Department of Medicine, Montefiore Medical Center, Bronx, NY, USA"},{"name":"Division of Hospital Medicine, Montefiore Medical Center, Bronx, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurel","family":"Mohrmann","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA"},{"name":"Department of Medicine, Montefiore Medical Center, Bronx, NY, USA"},{"name":"Division of Hospital Medicine, Montefiore Medical Center, Bronx, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei","family":"Assa","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, 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