{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:13:20Z","timestamp":1790709200436,"version":"4.1.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T00:00:00Z","timestamp":1628640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Global Malaria Program (World Health Organization), Communicable Diseases and Environmental Determinants of Health Department"},{"name":"Guyamazon 3 Program"},{"name":"French Ministry for Research"},{"name":"European Commission Grant (Regional Fund for Development","award":["GY0012082"],"award-info":[{"award-number":["GY0012082"]}]},{"name":"Sant\u00e9 Publique France as National Reference Centre for Malaria and Investissement d\u2019Avenir grant managed by Agence Nationale de la Recherche [CEBA","award":["ANR-10-LABX-25\u201301"],"award-info":[{"award-number":["ANR-10-LABX-25\u201301"]}]},{"DOI":"10.13039\/501100002830","name":"Centre National d\u2019Etudes Spatiales","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002830","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Amazonas-FAPEAM (PAPAC","award":["005\/2019"],"award-info":[{"award-number":["005\/2019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The first potential focus for artemisinin resistance in South America was recently confirmed with the presence of the C580Y mutation in the Plasmodium falciparum kelch 13 gene (pfk13) in Guyana.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>This study aimed to strengthen pfk13 monitoring in the Amazon basin countries, to compile the available data and to evaluate the risk of spreading of mutations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Sanger sequencing was done on 862 samples collected between 1998 and 2019, and a global map of pfk13 genotypes available for this region was constructed. Then, the risk of spreading of mutations based on P. falciparum case importation between 2015 and 2018 within countries of the Amazon basin was evaluated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>No additional pfk13 C580Y foci were identified. Few mutations (0.5%, 95% CI\u2009=\u20090.3%\u20130.8%) in the propeller domain were observed in the general parasite population of this region despite a high proportion of K189T mutations (49.1%, 95% CI\u2009=\u200946.2%\u201352.0%) in the non-propeller domain. Case information revealed two patterns of intense human migration: Venezuela, Guyana and the Roraima State in Brazil; and French Guiana, Suriname and the Amap\u00e1 State in Brazil.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>There are few pfk13 mutant foci, but a high risk of dispersion in the Amazon basin, mainly from the Guiana Shield, proportionate to mining activities. Therefore, access to prompt diagnosis and treatment, and continuous molecular monitoring is essential in these geographical areas.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkab264","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T19:17:56Z","timestamp":1628191076000},"page":"2854-2862","source":"Crossref","is-referenced-by-count":24,"title":["Kelch13 mutations in <i>Plasmodium falciparum<\/i> and risk of spreading in Amazon basin countries"],"prefix":"10.1093","volume":"76","author":[{"given":"Luana C","family":"Mathieu","sequence":"first","affiliation":[{"name":"Laboratoire de parasitologie, Centre Nationale de R\u00e9f\u00e9rence du Paludisme, World Health Organization Collaborating Center for surveillance of antimalarial drug resistance, Institut Pasteur de la Guyane, 97306 Cayenne, French Guiana"},{"name":"Ecole Doctorale n\u00b0587 \u00ab Diversit\u00e9s, Sant\u00e9, et D\u00e9veloppement en Amazonie \u00bb, Universit\u00e9 de Guyane, 97300 Cayenne, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabhjot","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Communicable Diseases and Environmental Determinants of Health, Pan American Health Organization\/World Health Organization, Washington, DC 20037, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuelton Marcelo","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Diretoria de Ensino e Pesquisa, Funda\u00e7\u00e3o de Medicina Tropical Dr. Heitor Vieira Dourado, 69040-200 Manaus, Amazonas, Brazil"},{"name":"Escola de Ci\u00eancias da Sa\u00fade, Universidade do Estado do Amazonas, 69050-010 Manaus, Amazonas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magda","family":"Magris","sequence":"additional","affiliation":[{"name":"Amazonic Center for Research and Control of Tropical Diseases \u201cSim\u00f3n Bol\u00edvar\u201d, 7101, Puerto Ayacucho, Amazonas State, Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horace","family":"Cox","sequence":"additional","affiliation":[{"name":"National Malaria Program, Ministry of Public Health, 0592 Georgetown, Guyana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yassamine","family":"Lazrek","sequence":"additional","affiliation":[{"name":"Laboratoire de parasitologie, Centre Nationale de R\u00e9f\u00e9rence du Paludisme, World Health Organization Collaborating Center for surveillance of antimalarial drug resistance, Institut Pasteur de la Guyane, 97306 Cayenne, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisely C","family":"Melo","sequence":"additional","affiliation":[{"name":"Diretoria de Ensino e Pesquisa, Funda\u00e7\u00e3o de Medicina Tropical Dr. Heitor Vieira Dourado, 69040-200 Manaus, Amazonas, Brazil"},{"name":"Escola de Ci\u00eancias da Sa\u00fade, Universidade do Estado do Amazonas, 69050-010 Manaus, Amazonas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Marchesini","sequence":"additional","affiliation":[{"name":"Malaria Technical Group, Vector Transmissible and Zoonotic Diseases Coordination, Ministry of Health, 70058-900 Brasilia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean S F","family":"Alexandre","sequence":"additional","affiliation":[{"name":"Pan American Health Organization, Georgetown, Guyana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel Manuel","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Pan American Health Organization, Caracas, Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magalie","family":"Demar","sequence":"additional","affiliation":[{"name":"Service de Maladies Infectieuses et Tropicales, Centre Hospitalier Andr\u00e9e Rosemon, 97300 Cayenne, French Guiana"},{"name":"Ecosyst\u00e8mes Amazoniens et Pathologie Tropicale (EPAT), EA3593, Universit\u00e9 de Guyane, 97300 Cayenne, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maylis","family":"Douine","sequence":"additional","affiliation":[{"name":"Ecosyst\u00e8mes Amazoniens et Pathologie Tropicale (EPAT), EA3593, Universit\u00e9 de Guyane, 97300 Cayenne, French Guiana"},{"name":"Centre d'Investigation Clinique Antilles-Guyane (Inserm 1424), H\u00f4pital de Cayenne, 97300 Cayenne, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Paz","family":"Ade","sequence":"additional","affiliation":[{"name":"Department of Communicable Diseases and Environmental Determinants of Health, Pan American Health Organization\/World Health Organization, Washington, DC 20037, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus V G","family":"Lacerda","sequence":"additional","affiliation":[{"name":"Diretoria de Ensino e Pesquisa, Funda\u00e7\u00e3o de Medicina Tropical Dr. Heitor Vieira Dourado, 69040-200 Manaus, Amazonas, Brazil"},{"name":"Instituto Le\u00f4nidas & Maria Deane, Fiocruz, 69057-070 Manaus, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0215-4110","authenticated-orcid":false,"given":"Lise","family":"Musset","sequence":"additional","affiliation":[{"name":"Laboratoire de parasitologie, Centre Nationale de R\u00e9f\u00e9rence du Paludisme, World Health Organization Collaborating Center for surveillance of antimalarial drug resistance, Institut Pasteur de la Guyane, 97306 Cayenne, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,8,11]]},"reference":[{"key":"2021101808540175200_dkab264-B1","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1056\/NEJMoa0808859","article-title":"Artemisinin resistance in Plasmodium falciparum malaria","volume":"361","author":"Dondorp","year":"2009","journal-title":"N Engl J Med"},{"key":"2021101808540175200_dkab264-B2","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S1473-3099(17)30048-8","article-title":"The spread of artemisinin-resistant Plasmodium falciparum in the Greater Mekong subregion: a molecular epidemiology observational study","volume":"17","author":"Imwong","year":"2017","journal-title":"Lancet Infect Dis"},{"key":"2021101808540175200_dkab264-B3","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nature12876","article-title":"A molecular marker of artemisinin-resistant Plasmodium falciparum malaria","volume":"505","author":"Ariey","year":"2014","journal-title":"Nature"},{"key":"2021101808540175200_dkab264-B4","year":"2018"},{"key":"2021101808540175200_dkab264-B5","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1093\/molbev\/msw228","article-title":"Population parameters underlying an ongoing soft sweep in Southeast Asian malaria parasites","volume":"34","author":"Anderson","year":"2017","journal-title":"Mol Biol Evol"},{"key":"2021101808540175200_dkab264-B6","year":"2020"},{"key":"2021101808540175200_dkab264-B7","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1093\/infdis\/jiv752","article-title":"Independent emergence of the Plasmodium falciparum kelch propeller domain mutant allele C580Y in Guyana","volume":"213","author":"Chenet","year":"2016","journal-title":"J Infect Dis"},{"key":"2021101808540175200_dkab264-B8","doi-asserted-by":"crossref","first-page":"e51015","DOI":"10.7554\/eLife.51015","article-title":"Local emergence in Amazonia of Plasmodium falciparum k13 C580Y mutants associated with in vitro artemisinin resistance","volume":"9","author":"Mathieu","year":"2020","journal-title":"eLife"},{"key":"2021101808540175200_dkab264-B9","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S1473-3099(13)70252-4","article-title":"Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies","volume":"13","author":"Witkowski","year":"2013","journal-title":"Lancet Infect Dis"},{"key":"2021101808540175200_dkab264-B10","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.4269\/ajtmh.18-0554","article-title":"Absence of Plasmodium falciparum K13 propeller domain polymorphisms among field isolates collected from the Brazilian Amazon basin between 1984 and 2011","volume":"99","author":"Inoue","year":"2018","journal-title":"Am J Trop Med Hyg"},{"key":"2021101808540175200_dkab264-B11","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1056\/NEJMoa1513137","article-title":"A worldwide map of Plasmodium falciparum K13-propeller polymorphisms","volume":"374","author":"M\u00e9nard","year":"2016","journal-title":"N Engl J Med"},{"key":"2021101808540175200_dkab264-B12","doi-asserted-by":"crossref","first-page":"e00354-18","DOI":"10.1128\/AAC.00354-18","article-title":"Absence of K13 polymorphism in Plasmodium falciparum from Brazilian areas where the parasite is endemic","volume":"62","author":"Gomes","year":"2018","journal-title":"Antimicrob Agents Chemother"},{"key":"2021101808540175200_dkab264-B13","doi-asserted-by":"crossref","first-page":"3340","DOI":"10.1128\/AAC.02370-15","article-title":"Little polymorphism at the K13 propeller locus in worldwide Plasmodium falciparum populations prior to the introduction of artemisinin combination therapies","volume":"60","author":"Mita","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"2021101808540175200_dkab264-B14","doi-asserted-by":"crossref","first-page":"e20180225","DOI":"10.1590\/0037-8682-0225-2018","article-title":"Plasmodium falciparum malarial parasites from Brazil lack artemisinin resistance-associated mutations in the kelch13 gene","volume":"52","author":"Chapadense","year":"2019","journal-title":"Rev Soc Bras Med Trop"},{"key":"2021101808540175200_dkab264-B15","doi-asserted-by":"crossref","first-page":"148","DOI":"10.4269\/ajtmh.16-0017","article-title":"No clinical or molecular evidence of Plasmodium falciparum resistance to artesunate\u2013mefloquine in Northwestern Brazil","volume":"95","author":"Ladeia-Andrade","year":"2016","journal-title":"Am J Trop Med Hyg"},{"key":"2021101808540175200_dkab264-B16","doi-asserted-by":"crossref","first-page":"88","DOI":"10.4269\/ajtmh.17-0623","article-title":"Efficacy of artemether\u2013lumefantrine for uncomplicated Plasmodium falciparum malaria in Cruzeiro do Sul, Brazil, 2016","volume":"98","author":"Itoh","year":"2018","journal-title":"Am J Trop Med Hyg"},{"key":"2021101808540175200_dkab264-B17","doi-asserted-by":"crossref","first-page":"310","DOI":"10.4269\/ajtmh.19-0749","article-title":"Molecular surveillance for polymorphisms associated with artemisinin-based combination therapy resistance in Plasmodium falciparum isolates collected in the State of Roraima, Brazil","volume":"102","author":"Lucchi","year":"2020","journal-title":"Am J Trop Med Hyg"},{"key":"2021101808540175200_dkab264-B18","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/trstmh\/trx021","article-title":"Baseline in vivo, ex vivo and molecular responses of Plasmodium falciparum to artemether and lumefantrine in three endemic zones for malaria in Colombia","volume":"111","author":"Aponte","year":"2017","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"2021101808540175200_dkab264-B19","doi-asserted-by":"crossref","first-page":"e01036-17","DOI":"10.1128\/AAC.01036-17","article-title":"K13 propeller alleles, mdr1 polymorphism, and drug effectiveness at day 3 after artemether-lumefantrine treatment for Plasmodium falciparum malaria in Colombia, 2014-2015","volume":"61","author":"Montenegro","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"2021101808540175200_dkab264-B20","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.4269\/ajtmh.19-0954","article-title":"Artemether-lumefantrine efficacy for the treatment of uncomplicated Plasmodium falciparum malaria in Choco, Colombia after 8 years as first-line treatment","volume":"102","author":"Olivera","year":"2020","journal-title":"Am J Trop Med Hyg"},{"key":"2021101808540175200_dkab264-B21","doi-asserted-by":"crossref","first-page":"ofw185","DOI":"10.1093\/ofid\/ofw185","article-title":"Continued sensitivity of Plasmodium falciparum to artemisinin in Guyana, with absence of Kelch propeller domain mutant alleles","volume":"3","author":"Rahman","year":"2016","journal-title":"Open Forum Infect Dis"},{"key":"2021101808540175200_dkab264-B22","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1186\/s12936-019-3044-z","article-title":"Genotypes and phenotypes of resistance in Ecuadorian Plasmodium falciparum","volume":"18","author":"Valenzuela","year":"2019","journal-title":"Malar J"},{"key":"2021101808540175200_dkab264-B23","doi-asserted-by":"crossref","first-page":"e02655-16","DOI":"10.1128\/AAC.02655-16","article-title":"Molecular profile of malaria drug resistance markers of Plasmodium falciparum in Suriname","volume":"61","author":"Chenet","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"2021101808540175200_dkab264-B24","year":"2020"},{"key":"2021101808540175200_dkab264-B25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12916-018-1207-3","article-title":"Association of mutations in the Plasmodium falciparum Kelch13 gene (Pf3D7_1343700) with parasite clearance rates after artemisinin-based treatments\u2014a WWARN individual patient data meta-analysis","volume":"17","year":"2019","journal-title":"BMC Med"},{"key":"2021101808540175200_dkab264-B26","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1128\/AAC.01346-15","article-title":"Emergence of mutations in the K13 propeller gene of Plasmodium falciparum isolates from Dakar, Senegal, in 2013-2014","volume":"60","author":"Boussaroque","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"2021101808540175200_dkab264-B27","doi-asserted-by":"crossref","first-page":"e105690","DOI":"10.1371\/journal.pone.0105690","article-title":"Polymorphisms in K13 and falcipain-2 associated with artemisinin resistance are not prevalent in Plasmodium falciparum isolated from Ugandan children","volume":"9","author":"Conrad","year":"2014","journal-title":"PLoS One"},{"key":"2021101808540175200_dkab264-B28","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1186\/1475-2875-13-472","article-title":"Limited polymorphisms in k13 gene in Plasmodium falciparum isolates from Dakar, Senegal in 2012\u20132013","volume":"13","author":"Torrentino-Madamet","year":"2014","journal-title":"Malar J"},{"key":"2021101808540175200_dkab264-B29","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1056\/NEJMoa1314981","article-title":"Spread of artemisinin resistance in Plasmodium falciparum malaria","volume":"371","author":"Ashley","year":"2014","journal-title":"N Engl J Med"},{"key":"2021101808540175200_dkab264-B30","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1093\/infdis\/jiu491","article-title":"Independent emergence of artemisinin resistance mutations among Plasmodium falciparum in Southeast Asia","volume":"211","author":"Takala-Harrison","year":"2015","journal-title":"J Infect Dis"},{"key":"2021101808540175200_dkab264-B31","doi-asserted-by":"crossref","first-page":"6952","DOI":"10.1128\/AAC.01255-15","article-title":"Artemisinin resistance at the China-Myanmar border and association with mutations in the K13 propeller gene","volume":"59","author":"Wang","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"2021101808540175200_dkab264-B32","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1186\/s12936-015-0672-9","article-title":"Prevalence of K13-propeller polymorphisms in Plasmodium falciparum from China-Myanmar border in 2007\u20132012","volume":"14","author":"Wang","year":"2015","journal-title":"Malar J"},{"key":"2021101808540175200_dkab264-B33","doi-asserted-by":"crossref","first-page":"834","DOI":"10.3201\/eid2504.181355","article-title":"Effects of political instability in Venezuela on malaria resurgence at Ecuador\u2013Peru border, 2018","volume":"25","author":"Jaramillo-Ochoa","year":"2019","journal-title":"Emerg Infect Dis"},{"key":"2021101808540175200_dkab264-B34","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.bjid.2019.07.006","article-title":"Evaluation of emerging infectious disease and the importance of SINAN for epidemiological surveillance of Venezuelans immigrants in Brazil","volume":"23","author":"de Lima Junior","year":"2019","journal-title":"Braz J Infect Dis"},{"key":"2021101808540175200_dkab264-B35","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.tmaid.2019.02.004","article-title":"Consequences of Venezuela\u2019s massive migration crisis on imported malaria in Colombia, 2016\u20132018","volume":"28","author":"Rodr\u00edguez-Morales","year":"2019","journal-title":"Travel Med Infect Dis"},{"key":"2021101808540175200_dkab264-B36","doi-asserted-by":"crossref","first-page":"e0008211","DOI":"10.1371\/journal.pntd.0008211","article-title":"Malaria in Southern Venezuela: the hottest hotspot in Latin America","volume":"15","author":"Grillet","year":"2021","journal-title":"PLoS Negl Trop Dis"},{"key":"2021101808540175200_dkab264-B37","doi-asserted-by":"crossref","first-page":"e200043","DOI":"10.1590\/0074-02760200043","article-title":"The impact of imported malaria by gold miners in Roraima: characterizing the spatial dynamics of autochthonous and imported malaria in an urban region of Boa Vista","volume":"115","author":"Louzada","year":"2020","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"2021101808540175200_dkab264-B38","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s12936-021-03668-4","article-title":"Cross-border malaria in Northern Brazil","volume":"20","author":"Arisco","year":"2021","journal-title":"Malar J"},{"key":"2021101808540175200_dkab264-B39","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s40475-020-00202-5","article-title":"Malaria in gold miners in the Guianas and the Amazon: current knowledge and challenges","volume":"7","author":"Douine","year":"2020","journal-title":"Curr Trop Med Rep"},{"key":"2021101808540175200_dkab264-B40","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1186\/s12936-017-1925-6","article-title":"Malaria in Brazil, Colombia, Peru and Venezuela: current challenges in malaria control and elimination","volume":"16","author":"Recht","year":"2017","journal-title":"Malar J"},{"key":"2021101808540175200_dkab264-B41","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s12889-017-4557-4","article-title":"Illegal gold miners in French Guiana: a neglected population with poor health","volume":"18","author":"Douine","year":"2018","journal-title":"BMC Public Health"},{"key":"2021101808540175200_dkab264-B42","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1186\/s12936-016-1367-6","article-title":"Prevalence of Plasmodium spp. in illegal gold miners in French Guiana in 2015: a hidden but critical malaria reservoir","volume":"15","author":"Douine","year":"2016","journal-title":"Malar J"},{"key":"2021101808540175200_dkab264-B43","doi-asserted-by":"crossref","first-page":"e181046","DOI":"10.1590\/s0104-12902020181046","article-title":"Malaria in the borders between Brazil and French Guiana: social and environmental health determinants and their influence on the permanence of the disease","volume":"29","author":"Gomes","year":"2020","journal-title":"Sa\u00fade E Soc"},{"key":"2021101808540175200_dkab264-B44","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12936-018-2204-x","article-title":"Decreased endemic malaria in Suriname: moving towards elimination","volume":"17","author":"van Eer","year":"2018","journal-title":"Malar J"},{"key":"2021101808540175200_dkab264-B45","first-page":"e2019056","article-title":"Malaria among indigenous peoples on the Brazil-French Guiana border, 2007-2016: a descriptive study","volume":"29","author":"Mendes","year":"2020","journal-title":"Epidemiol E Servi\u00e7os Sa\u00fade"},{"key":"2021101808540175200_dkab264-B46","year":"2020"},{"key":"2021101808540175200_dkab264-B47","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S1473-3099(18)30068-9","article-title":"Origins of the current outbreak of multidrug-resistant malaria in southeast Asia: a retrospective genetic study","volume":"18","author":"Amato","year":"2018","journal-title":"Lancet Infect Dis"},{"key":"2021101808540175200_dkab264-B48","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/S1473-3099(19)30392-5","article-title":"Evolution and expansion of multidrug-resistant malaria in southeast Asia: a genomic epidemiology study","volume":"19","author":"Hamilton","year":"2019","journal-title":"Lancet Infect Dis"},{"key":"2021101808540175200_dkab264-B49","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1186\/s12936-018-2570-4","article-title":"Malaria epidemiology in Suriname from 2000 to 2016: trends, opportunities and challenges for elimination","volume":"17","author":"Hiwat","year":"2018","journal-title":"Malar J"},{"key":"2021101808540175200_dkab264-B50","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/s12936-018-2306-5","article-title":"Malakit: an innovative pilot project to self-diagnose and self-treat malaria among illegal gold miners in the Guiana Shield","volume":"17","author":"Douine","year":"2018","journal-title":"Malar J"},{"key":"2021101808540175200_dkab264-B51","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/jac\/dkx343","article-title":"Predictors of antimalarial self-medication in illegal gold miners in French Guiana: a pathway towards artemisinin resistance","volume":"73","author":"Douine","year":"2018","journal-title":"J Antimicrob Chemother"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/76\/11\/2854\/40641274\/dkab264.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/76\/11\/2854\/40641274\/dkab264.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T20:19:40Z","timestamp":1634761180000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article\/76\/11\/2854\/6348046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,11]]},"references-count":51,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,8,11]]},"published-print":{"date-parts":[[2021,10,11]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dkab264","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,11,1]]},"published":{"date-parts":[[2021,8,11]]}}}