{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T06:33:21Z","timestamp":1772865201624,"version":"3.50.1"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T00:00:00Z","timestamp":1627516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vancomycin remains a useful agent in the infection doctor\u2019s toolkit, particularly for Staphylococcus aureus and MRSA infections. Therapeutic drug monitoring (TDM) is essential to maintain efficacy and avoid toxicity. Until recently, trough-based dosing has been the recommended method but in recent years the reliability of this has been questioned. The 2020 Infectious Diseases Society of America (IDSA) vancomycin guideline update has sent a clear message that trough-based dosing is not to be relied on, instead recommending dosing via 24\u2009h AUC\/MIC. The UK, however, has yet to follow suit in this, despite the wealth of evidence showing that trough-based dosing puts patients at higher risk of nephrotoxicity. Clearly, it is time to incorporate AUC\/MIC-based dosing to utilize this effective antibiotic safely.<\/jats:p>","DOI":"10.1093\/jac\/dkab274","type":"journal-article","created":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T19:09:33Z","timestamp":1626376173000},"page":"3071-3072","source":"Crossref","is-referenced-by-count":5,"title":["Vancomycin in adult prescribing: is it time to move on from trough-based dosing in the UK?"],"prefix":"10.1093","volume":"76","author":[{"given":"F","family":"Heard","sequence":"first","affiliation":[{"name":"Microbiology Department, Queens Medical Centre, Nottingham University Hospitals Trust, Derby Road, Nottingham NG7 2UH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Sehgal","sequence":"additional","affiliation":[{"name":"Intensive Care Department, Lincoln Hospital, United Lincolnshire Hospitals Trust, Greetwell Road, Lincoln LN2 5QY, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,7,29]]},"reference":[{"key":"2021111722575298200_dkab274-B1"},{"key":"2021111722575298200_dkab274-B2","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1592\/phco.29.11.1275","article-title":"Therapeutic monitoring of vancomycin in adults","volume":"29","author":"Ryback","year":"2009","journal-title":"Pharmacotherapy"},{"key":"2021111722575298200_dkab274-B3","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1093\/ajhp\/zxaa036","article-title":"Therapeutic monitoring of vancomycin for serious Methicillin-resistant Staphylococcus aureus infections: a revised consensus guideline and review by the American Society of Health- System Pharmacists, the Infectious Diseases Society of America, the Paediatric Infectious Diseases Society, and the Society of Infectious Diseases Pharmacists","volume":"77","author":"Rybak","year":"2020","journal-title":"Am J Health Syst 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