{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T15:14:20Z","timestamp":1791126860277,"version":"4.1.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T00:00:00Z","timestamp":1630281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Programme Hospitalier de Recherche Clinique","award":["AOM 09024"],"award-info":[{"award-number":["AOM 09024"]}]},{"name":"French Ministry of Health"},{"name":"Direction de la Recherche Clinique de l\u2019Assistance Publique des H\u00f4pitaux de Paris"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Therapeutic failure is a frequent issue in the management of post-operative peritonitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>A post hoc analysis of the prospective, multicentre DURAPOP trial analysed the risk factors for failures in post-operative peritonitis following adequate source control and empirical antibiotic therapy in critically ill patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>Overall failures assessed post-operatively between Day\u20098 and Day\u200945 were defined as a composite of death and\/or surgical and\/or microbiological failures. Risk factors for failures were assessed using logistic regression analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 236 analysed patients, overall failures were reported in 141 (59.7%) patients, including 30 (12.7%) deaths, 81 (34.3%) surgical and 95 (40.2%) microbiological failures. In the multivariate analysis, the risk factors associated with overall failures were documented piperacillin\/tazobactam therapy [adjusted OR (aOR) 2.10; 95% CI 1.17\u20133.75] and renal replacement therapy on the day of reoperation (aOR 2.96; 95% CI 1.05\u20138.34). The risk factors for death were age (aOR 1.08 per year; 95% CI 1.03\u20131.12), renal replacement therapy on reoperation (aOR 3.95; 95% CI 1.36\u201311.49) and diabetes (OR 6.95; 95% CI 1.34\u201336.03). The risk factors associated with surgical failure were documented piperacillin\/tazobactam therapy (aOR 1.99; 95% CI 1.13\u20133.51), peritoneal cultures containing Klebsiella spp. (aOR 2.45; 95% CI 1.02\u20135.88) and pancreatic source of infection (aOR 2.91; 95% CI 1.21\u20137.01). No specific risk factors were identified for microbiological failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our data suggest a predominant role of comorbidities, the severity of post-operative peritonitis and possibly of documented piperacillin\/tazobactam treatment on the occurrence of therapeutic failures, regardless of their type.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jac\/dkab307","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T07:09:35Z","timestamp":1628147375000},"page":"3303-3309","source":"Crossref","is-referenced-by-count":10,"title":["Risk factors for therapeutic failure in the management of post-operative peritonitis: a\n                    <i>post hoc<\/i>\n                    analysis of the DURAPOP 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