{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T05:57:48Z","timestamp":1783576668841,"version":"3.55.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T00:00:00Z","timestamp":1634256000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Maintenance ART with dolutegravir-based dual regimens have proved their efficacy among HIV-1-infected subjects in randomized trials. However, real-life data are scarce, with limited populations and follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>We assessed virological failure (VF) and resistance-associated mutations (RAMs) on dolutegravir maintenance regimens in combination with rilpivirine or with lamivudine or emtricitabine (xTC) and analysed the factors associated with VF.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Between 2014 and 2018, all HIV-1-infected adults included in the Dat\u2019AIDS cohort and starting dolutegravir\/rilpivirine or dolutegravir\/xTC as a maintenance dolutegravir-based dual regimen were selected. VF was defined as two consecutive HIV RNA values &amp;gt;50 copies\/mL or a single value &amp;gt;400 copies\/mL. We compared cumulative genotypes before initiation of a maintenance dolutegravir-based dual regimen with genotype at VF.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We analysed 1374 subjects (799 on dolutegravir\/rilpivirine and 575 on dolutegravir\/xTC) with a median follow-up of 20\u2009months (IQR\u2009=\u200911\u201331) and 19\u2009months (IQR\u2009=\u200911\u201331), respectively. VF occurred in 3.8% (n\u2009=\u200930) of dolutegravir\/rilpivirine subjects and 2.6% (n\u2009=\u200915) of dolutegravir\/xTC subjects. Among subjects receiving dolutegravir\/rilpivirine, two genotypes harboured emerging RAMs at VF: E138K on NNRTI (n\u2009=\u20091); and E138K+K101E on NNRTI and N155H on INSTI (n\u2009=\u20091). Among subjects receiving dolutegravir\/xTC, no new RAM was detected. The only predictive factor of VF on dolutegravir\/rilpivirine was the history of failure on an NNRTI-based regimen (adjusted HR\u2009=\u20092.97, 95% CI\u2009=\u20091.28\u20136.93). No factor was associated with VF on dolutegravir\/xTC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In this large real-life cohort, dolutegravir\/rilpivirine and dolutegravir\/xTC sustained virological suppression and were associated with a low rate of VF and RAM emergence. Careful virological screening is essential before switching to dolutegravir\/rilpivirine in virologically suppressed patients with a history of NNRTI therapy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkab367","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T19:20:59Z","timestamp":1631733659000},"page":"196-204","source":"Crossref","is-referenced-by-count":14,"title":["Dolutegravir-based dual maintenance regimens combined with lamivudine\/emtricitabine or rilpivirine: risk of virological failure in a real-life setting"],"prefix":"10.1093","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1133-5207","authenticated-orcid":false,"given":"Colin","family":"Deschanvres","sequence":"first","affiliation":[{"name":"Infectious Diseases Department, Nantes University Hospital, Nantes, 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