{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:23:50Z","timestamp":1787009030982,"version":"build-2736575974"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T00:00:00Z","timestamp":1642550400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"NICHD","award":["U01HD071889"],"award-info":[{"award-number":["U01HD071889"]}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"crossref","award":["R03HD096131"],"award-info":[{"award-number":["R03HD096131"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Data evaluating the risk of proximal tubular dysfunction in women receiving tenofovir disoproxil fumarate for the prevention of mother-to-child transmission (PMTCT) of HBV are scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the risk of proximal tubulopathy in pregnant women receiving tenofovir disoproxil fumarate for PMTCT of HBV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>We used urine samples collected from HBV monoinfected pregnant women who participated in a Phase III, multicentre, randomized, double-blind, placebo-controlled clinical trial assessing a tenofovir disoproxil fumarate short course from 28 weeks gestational age (28-wk-GA) to 2 months post-partum (2-months-PP) for PMTCT of HBV in Thailand. Markers of tubular dysfunction, including retinol binding protein, kidney injury molecule-1, \u03b11-microglobuin and \u03b22-microglobulin, were assayed at 28- and 32-wk-GA and 2-months-PP visits. Proximal tubulopathy was defined as the presence of \u22652 of the following: tubular proteinuria, euglycaemic glycosuria and increased urinary phosphate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 291 women participated in the study. No kidney-related adverse events were severe, and none led to tenofovir disoproxil fumarate discontinuation. At 2-months-PP, 3 of the 120 (3%) evaluated women in the tenofovir disoproxil fumarate group experienced proximal tubulopathy versus 3 of 125 (2%) in the placebo group (P = 1.00). None of the six women met the criteria for proximal tubulopathy at 12-months-PP but proteinuria persisted in three of them. No growth abnormalities were found at 1 year of age in infants born to mothers with proximal tubulopathy at 2-months-PP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In these HBV-infected pregnant and breastfeeding women, tenofovir disoproxil fumarate administered from 28-wk-GA to 2-months-PP was not associated with a higher risk of proximal tubulopathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jac\/dkab490","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T07:08:34Z","timestamp":1640070514000},"page":"1111-1118","source":"Crossref","is-referenced-by-count":2,"title":["Proximal tubular dysfunction in pregnant women receiving tenofovir disoproxil fumarate to prevent mother-to-child transmission of hepatitis B virus"],"prefix":"10.1093","volume":"77","author":[{"given":"Geoffroy","family":"Liegeon","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, H\u00f4pital Saint-Louis et Lariboisi\u00e8re, Assistance Publique\u2013H\u00f4pitaux de Paris, Universit\u00e9 de Paris, Paris, France"},{"name":"MIVEGEC, Universit\u00e9 Montpellier, CNRS, IRD, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Ngo-Giang-Huong","sequence":"additional","affiliation":[{"name":"MIVEGEC, Universit\u00e9 Montpellier, CNRS, IRD, Montpellier, France"},{"name":"Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Salvadori","sequence":"additional","affiliation":[{"name":"MIVEGEC, Universit\u00e9 Montpellier, CNRS, IRD, Montpellier, France"},{"name":"Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piyawan","family":"Bunpo","sequence":"additional","affiliation":[{"name":"Division of Clinical Chemistry, Faculty of Associated Medical Sciences, Chiang Mai University, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratchada","family":"Cressey","sequence":"additional","affiliation":[{"name":"Division of Clinical Chemistry, Faculty of Associated Medical Sciences, Chiang Mai University, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jullapong","family":"Achalapong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prateep","family":"Kanjanavikai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Banglamung Hospital, Chonburi, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orada","family":"Patamasingh Na Ayudhaya","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Nopparat Rajathanee Hospital, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinart","family":"Prommas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Bhumibol Adulyadej Hospital, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thitiporn","family":"Siriwachirachai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Khon Kaen Hospital, Khon Kaen, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prapan","family":"Sabsanong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Samutsakhon Hospital, Samutsakhon, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Yves Mary","sequence":"additional","affiliation":[{"name":"INSERM U1153, Team ECSTRA, Universit\u00e9 Paris Diderot \u2013 Paris 7, H\u00f4pital Saint-Louis, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzague","family":"Jourdain","sequence":"additional","affiliation":[{"name":"MIVEGEC, Universit\u00e9 Montpellier, CNRS, IRD, Montpellier, France"},{"name":"Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,1,19]]},"reference":[{"key":"2022052021524201800_dkab490-B1","article-title":"Global hepatitis report, 2017","author":"WHO","year":"2017"},{"key":"2022052021524201800_dkab490-B2","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1053\/j.gastro.2011.12.035","article-title":"Effects of maternal screening and universal immunization to prevent mother-to-infant transmission of HBV","volume":"142","author":"Chen","year":"2012","journal-title":"Gastroenterology"},{"key":"2022052021524201800_dkab490-B3","unstructured":"WHO . Prevention of mother-to-child transmission of hepatitis B virus: guidelines on antiviral prophylaxis in pregnancy. 2020. https:\/\/www.who.int\/publications-detail-redirect\/978-92-4-000270-8."},{"key":"2022052021524201800_dkab490-B4","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/s41575-020-00361-w","article-title":"Viral hepatitis and pregnancy","volume":"18","author":"Terrault","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"2022052021524201800_dkab490-B5","first-page":"59","article-title":"Renal and bone toxicity with the use of tenofovir: understanding at the end","volume":"18","author":"Casado","year":"2016","journal-title":"AIDS Rev"},{"key":"2022052021524201800_dkab490-B6","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1002\/hep.27730","article-title":"Tenofovir-associated Fanconi syndrome and nephrotic syndrome in a patient with chronic hepatitis B 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