{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:30:31Z","timestamp":1790677831811,"version":"4.1.0"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T00:00:00Z","timestamp":1649808000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"French Ministry of Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To characterize Acinetobacter baumannii strains co-producing the ESBL CTX-M-115 and carbapenem-hydrolysing class D \u03b2-lactamases (CHDLs), and to assess the potential diffusion of their resistance genes by horizontal transfer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Nineteen CTX-M-115\/CHDL-positive A. baumannii were collected between 2015 and 2019 from patients hospitalized in France. Their whole-genome sequences were determined on Illumina and Oxford Nanopore platforms and were compared through core-genome MLST (cgMLST) and SNP analyses. Transferability of resistance genes was investigated by natural transformation assays.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eighteen strains were found to harbour CHDL OXA-72, and another one CHDL OXA-23, in addition to CTX-M-115, narrow-spectrum \u03b2-lactamases and aminoglycoside resistance determinants including ArmA. cgMLST typing, as well as Oxford Scheme ST and K locus typing, confirmed that 17 out of the 18 CTX-M-115\/OXA-72 isolates belonged to new subclades within clonal complex 78 (CC78). The chromosomal region carrying the blaCTX-M-115 gene appeared to vary greatly both in gene content and in length (from 20 to 79\u2005kb) among the strains, likely because of IS26-mediated DNA rearrangements. The blaOXA-72 gene was localized on closely related plasmids showing structural variations that occurred between pdif sites. Transfer of all the \u03b2-lactamase genes, as well as aminoglycoside resistance determinants to a drug-susceptible A. baumannii recipient, was easily obtained in vitro by natural transformation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This work highlights the propensity of CC78 isolates to collect multiple antibiotic resistance genes, to rearrange and to pass them to other A. baumannii strains via natural transformation. This process, along with mobile genetic elements, likely contributes to the considerable genomic plasticity of clinical strains, and to the diversity of molecular mechanisms sustaining their multidrug resistance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jac\/dkac099","type":"journal-article","created":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T08:58:14Z","timestamp":1649753894000},"page":"1542-1552","source":"Crossref","is-referenced-by-count":16,"title":["Genomic analysis of CTX-M-115 and OXA-23\/-72 co-producing\n                    <i>Acinetobacter baumannii<\/i>\n                    , and their potential to spread resistance genes by natural transformation"],"prefix":"10.1093","volume":"77","author":[{"given":"Jean-Baptiste","family":"Vuillemenot","sequence":"first","affiliation":[{"name":"Centre National de R\u00e9f\u00e9rence de la R\u00e9sistance aux Antibiotiques, Centre Hospitalier Universitaire de Besan\u00e7on , France"},{"name":"Laboratoire de Bact\u00e9riologie, UMR 6249 Chrono-Environnement, UFR Sant\u00e9, Universit\u00e9 Bourgogne Franche-Comt\u00e9 , Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Bour","sequence":"additional","affiliation":[{"name":"Centre National de R\u00e9f\u00e9rence de la R\u00e9sistance aux Antibiotiques, Centre Hospitalier Universitaire de Besan\u00e7on , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Racha","family":"Beyrouthy","sequence":"additional","affiliation":[{"name":"UMR INSERM 1071 USC INRA2018, Universit\u00e9 Clermont Auvergne , Clermont-Ferrand, France"},{"name":"Laboratoire associ\u00e9 Centre National de R\u00e9f\u00e9rence de la R\u00e9sistance aux Antibiotiques, Centre Hospitalier Universitaire de Clermont-Ferrand , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Bonnet","sequence":"additional","affiliation":[{"name":"UMR INSERM 1071 USC INRA2018, Universit\u00e9 Clermont Auvergne , Clermont-Ferrand, France"},{"name":"Laboratoire associ\u00e9 Centre National de R\u00e9f\u00e9rence de la R\u00e9sistance aux Antibiotiques, Centre Hospitalier Universitaire de Clermont-Ferrand , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Halima","family":"Laaberki","sequence":"additional","affiliation":[{"name":"CIRI, Centre International de Recherche en Infectiologie, INSERM U1111, Universit\u00e9 Claude Bernard Lyon 1 , Villeurbanne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9039-8021","authenticated-orcid":false,"given":"Xavier","family":"Charpentier","sequence":"additional","affiliation":[{"name":"CIRI, Centre International de Recherche en Infectiologie, INSERM U1111, Universit\u00e9 Claude Bernard Lyon 1 , Villeurbanne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Ruimy","sequence":"additional","affiliation":[{"name":"Laboratoire de Bact\u00e9riologie, Centre Hospitalier Universitaire de Nice, UMR INSERM C3M, Universit\u00e9 C\u00f4te d\u2019Azur , Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Pl\u00e9siat","sequence":"additional","affiliation":[{"name":"Centre National de R\u00e9f\u00e9rence de la R\u00e9sistance aux Antibiotiques, Centre Hospitalier Universitaire de Besan\u00e7on , France"},{"name":"Laboratoire de Bact\u00e9riologie, UMR 6249 Chrono-Environnement, UFR Sant\u00e9, Universit\u00e9 Bourgogne Franche-Comt\u00e9 , Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2966-7947","authenticated-orcid":false,"given":"Ana\u00efs","family":"Potron","sequence":"additional","affiliation":[{"name":"Centre National de R\u00e9f\u00e9rence de la R\u00e9sistance aux Antibiotiques, Centre Hospitalier Universitaire de Besan\u00e7on , France"},{"name":"Laboratoire de Bact\u00e9riologie, UMR 6249 Chrono-Environnement, UFR Sant\u00e9, Universit\u00e9 Bourgogne Franche-Comt\u00e9 , Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,4,13]]},"reference":[{"key":"2022053122483650400_dkac099-B1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1086\/595011","article-title":"Bad bugs, no drugs: no ESKAPE! 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