{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:58:33Z","timestamp":1791979113543,"version":"4.4.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T00:00:00Z","timestamp":1653523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"crossref","award":["110-2628-B-002-059"],"award-info":[{"award-number":["110-2628-B-002-059"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"crossref","award":["110-2326-B-002-003-MY3"],"award-info":[{"award-number":["110-2326-B-002-003-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"crossref","award":["110-2314-B-002-250"],"award-info":[{"award-number":["110-2314-B-002-250"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare, Taiwan","doi-asserted-by":"crossref","award":["MOHW110-TDU-B-211-124002"],"award-info":[{"award-number":["MOHW110-TDU-B-211-124002"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006737","name":"NTUH","doi-asserted-by":"crossref","award":["110-S4901"],"award-info":[{"award-number":["110-S4901"]}],"id":[{"id":"10.13039\/501100006737","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The CLSI recommended high-dose daptomycin (8\u201312\u2005mg\/kg) for treating Enterococcus faecium bloodstream infections (BSI). The current study was designed to determine the safety and efficacy of increasing the daptomycin dose for VRE BSI patients receiving \u22658\u2005mg\/kg.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a multicentre prospective observational study of patients who received a \u22658\u2005mg\/kg dose of daptomycin for treatment of VRE BSI. The primary outcome was 28\u2005day mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 661 patients were included. The 28\u2005day mortality rate was 45.1%. The survivors received higher doses of daptomycin than non-survivors (10.1 versus 9.8\u2005mg\/kg; P\u200a&amp;lt;\u200a0.001). An increase in the daptomycin dose independently predicted lower mortality [adjusted OR (aOR)\u200a=\u200a0.85; 95% CI\u200a=\u200a0.73\u20130.99; P\u200a=\u200a0.03]. Eighty-six survivors (23.7%) and 43 non-survivors (14.4%) received a \u226511\u2005mg\/kg dose of daptomycin (P\u200a=\u200a0.003). The 8 to &amp;lt;11 and \u226511\u2005mg\/kg doses of daptomycin differed in the 28\u2005day mortality in the higher MIC group (\u22652\u2005mg\/L) (49.4% versus 33.3%; P\u200a=\u200a0.004), but not in the lower MIC group (\u22641\u2005mg\/L) (29.3% versus 29.4%; P\u200a=\u200a0.99). A dose of \u226511\u2005mg\/kg was associated with a higher (3.9%) rate of highly elevated creatine kinase (&amp;gt;2000\u2005U\/L) compared with 1.1% with 8 to &amp;lt;11\u2005mg\/kg (P\u200a=\u200a0.04).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The efficacy of daptomycin is dose dependent. A high daptomycin dose, especially at \u226511\u2005mg\/kg, improved survival in patients with VRE BSI, but was associated with highly elevated creatine kinase. We recommend a \u226511\u2005mg\/kg dose of daptomycin be considered for treatment of VRE BSI, particularly for isolates with higher MICs.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkac164","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T19:19:06Z","timestamp":1652210346000},"page":"2278-2287","source":"Crossref","is-referenced-by-count":28,"title":["Influence of daptomycin doses on the outcomes of VRE bloodstream infection treated with high-dose daptomycin"],"prefix":"10.1093","volume":"77","author":[{"given":"Yu Chung","family":"Chuang","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital , Taipei , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin Yi","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Economics, National Chengchi University , Taipei , 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