{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:11:50Z","timestamp":1790831510385,"version":"4.1.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T00:00:00Z","timestamp":1657152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016913","name":"MSDAVENIR","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100016913","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003762","name":"Institut Pasteur","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003762","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>In Southeast-Asia, where many conditions associated with dissemination of ESBL-producing Enterobacterales (ESBL-E) in the community are met, data from the community are scarce but show high ESBL-E carriage prevalence. Maternal ESBL-E colonization is considered a risk factor for neonatal colonization, which is the first step towards developing neonatal sepsis. Despite this, ESBL-E carriage prevalence and its risk factors during pregnancy or postpartum remain undefined in Southeast-Asia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To estimate the prevalence of ESBL-E faecal colonization among peripartum women in the community of an urban and a rural area in Cambodia, to investigate ESBL-E genomic characteristics and to identify associated risk factors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Epidemiological data and faecal samples from 423 peripartum women were collected in an urban and rural areas in Cambodia (2015\u201316). Bacterial cultures, antibiotic susceptibility tests and ESBL gene sequencing were performed. Risk factor analysis was conducted using logistic regression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The prevalence of ESBL-E faecal carriage was 79.2% (95% CI 75.0%\u201382.8%) among which Escherichia coli (n\u200a=\u200a315\/335, 94.0%) were most frequent. All isolates were multidrug resistant. Among 318 ESBL-E, the genes most frequently detected were blaCTX-M-15 (41.5%), blaCTX-M-55 (24.8%), and blaCTX-M-27 (15.1%). Low income, undernutrition, multiparity, regular consumption of pork, dried meat, and raw vegetables, were associated with ESBL-E faecal carriage.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The high prevalence of ESBL-E carriage observed among peripartum women in Southeast-Asia and the identified associated factors underline the urgent need for public health measures to address antimicrobial resistance, including a \u2018One Health\u2019 approach.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkac224","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T03:37:13Z","timestamp":1657165033000},"page":"2658-2666","source":"Crossref","is-referenced-by-count":9,"title":["Prevalence and factors associated with faecal carriage of extended-spectrum \u03b2-lactamase-producing Enterobacterales among peripartum women in the community in Cambodia"],"prefix":"10.1093","volume":"77","author":[{"given":"Agathe","family":"de Lauzanne","sequence":"first","affiliation":[{"name":"Institut Pasteur du Cambodge , Phnom Penh , Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navin","family":"Sreng","sequence":"additional","affiliation":[{"name":"Institut Pasteur du Cambodge , Phnom Penh , Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa","family":"Foucaud","sequence":"additional","affiliation":[{"name":"Assistance Publique\/H\u00f4pitaux de Paris, H\u00f4pital Jean Verdier , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Touch","family":"Sok","sequence":"additional","affiliation":[{"name":"Cambodian Communicable Disease Control Department , Phnom Penh , Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thida","family":"Chon","sequence":"additional","affiliation":[{"name":"Institut Pasteur du Cambodge , Phnom Penh , 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