{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:42:44Z","timestamp":1791852164097,"version":"4.3.4"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T00:00:00Z","timestamp":1657497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"French National Reference Centre for Antimicrobial Resistance"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Despite the fact that carbapenem-resistant Enterobacterales (CRE) mostly cause urinary tract infections (UTIs), only few studies have focused on the efficacity of mecillinam against these CRE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the mecillinam susceptibility of a huge collection of CRE, including carbapenemase-producing Enterobacterales (CPE) and non-CPE (ESBL and AmpC producers with decreased permeability of the outer membrane).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 8310 non-duplicate clinical CRE, including 4042 OXA-48-like producers, 1094 NDM producers, 411 VIM producers, 174 KPC producers, 42 IMI producers, 153 multiple-carbapenemase producers and 45 isolates producing other types of carbapenemases (such as IMP-like enzymes or GES-5), were included in the study. WGS was performed on all CPE using Illumina technology. Categorization of susceptibility to mecillinam was performed using disc diffusion (mecillinam discs at 10\u2005\u03bcg; I2A, France) according to EUCAST recommendations. The results were interpreted according to EUCAST guidelines (S \u226515\u2005mm).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Significantly higher susceptibility rates were observed for carbapenem-resistant Proteus spp. (85%) and carbapenem-resistant Escherichia coli (84%), which are the two most common species responsible for UTIs, than for Klebsiella pneumoniae (67%), Enterobacter cloacae complex (75%), Citrobacter spp. (65%), Serratia spp. (34%) and Morganella morganii (12%). Susceptibility rates were 84%, 71% and 91% for OXA-48-like, NDM and IMI producers and 70% for non-CPE CRE. Mecillinam was less active against VIM and KPC producers (14% and 0%, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Mecillinam might be an alternative for the treatment of infections due to CRE, particularly UTIs, except for VIM and KPC producers and for M. morganii and Serratia spp species.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jac\/dkac226","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T05:55:42Z","timestamp":1657518942000},"page":"2835-2839","source":"Crossref","is-referenced-by-count":21,"title":["Activity of mecillinam against carbapenem-resistant Enterobacterales"],"prefix":"10.1093","volume":"77","author":[{"given":"C\u00e9cile","family":"Emeraud","sequence":"first","affiliation":[{"name":"Department of Bacteriology-Hygiene, Bic\u00eatre Hospital, Assistance Publique - H\u00f4pitaux de Paris , Le Kremlin-Bic\u00eatre , France"},{"name":"INSERM UMR 1184, RESIST Unit, Paris-Saclay University, Faculty of Medicine , Le Kremlin-Bic\u00eatre , France"},{"name":"French National Reference Centre for Antimicrobial Resistance , Le Kremlin-Bic\u00eatre , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Godmer","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Saint-Antoine Hospital, APHP.Sorbonne-Universit\u00e9 , Paris , France"},{"name":"Sorbonne Universit\u00e9, Centre d\u2019Immunologie et des Maladies Infectieuses (Cimi-Paris), UMR 1135, Centre National de R\u00e9f\u00e9rence des Mycobact\u00e9ries , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Girlich","sequence":"additional","affiliation":[{"name":"INSERM UMR 1184, RESIST Unit, Paris-Saclay University, Faculty of Medicine , Le Kremlin-Bic\u00eatre , 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Kremlin-Bic\u00eatre , France"},{"name":"INSERM UMR 1184, RESIST Unit, Paris-Saclay University, Faculty of Medicine , Le Kremlin-Bic\u00eatre , France"},{"name":"French National Reference Centre for Antimicrobial Resistance , Le Kremlin-Bic\u00eatre , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9937-9572","authenticated-orcid":false,"given":"Thierry","family":"Naas","sequence":"additional","affiliation":[{"name":"Department of Bacteriology-Hygiene, Bic\u00eatre Hospital, Assistance Publique - H\u00f4pitaux de Paris , Le Kremlin-Bic\u00eatre , France"},{"name":"INSERM UMR 1184, RESIST Unit, Paris-Saclay University, Faculty of Medicine , Le Kremlin-Bic\u00eatre , France"},{"name":"French National Reference Centre for Antimicrobial Resistance , Le Kremlin-Bic\u00eatre , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2307-3232","authenticated-orcid":false,"given":"R\u00e9my 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