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We sought to quantify PK\/PD attainment in patients with hospital-acquired pneumonia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Meropenem plasma PK data (n\u200a=\u200a70 patients) were modelled, PK\/PD attainment rates were calculated for empirical and definitive targets, and between-patient variability was quantified [as a coefficient of variation (CV%)].<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Attainment of 100% T&amp;gt;4\u00d7MIC was variable for both empirical (CV%\u200a=\u200a92) and directed (CV%\u200a=\u200a33%) treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Individualization is required to achieve suggested PK\/PD targets in critically ill patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkac245","type":"journal-article","created":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T08:19:10Z","timestamp":1658564350000},"page":"2956-2959","source":"Crossref","is-referenced-by-count":6,"title":["Individual target pharmacokinetic\/pharmacodynamic attainment rates among meropenem-treated patients admitted to the ICU with hospital-acquired pneumonia"],"prefix":"10.1093","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2343-8198","authenticated-orcid":false,"given":"Roxane","family":"Rohani","sequence":"first","affiliation":[{"name":"Midwestern University College of Pharmacy Downers Grove Campus , Downers Grove, IL , USA"},{"name":"Midwestern University College of Pharmacy Downers Grove Campus, Pharmacometrics Center of Excellence , Downers Grove, IL , USA"},{"name":"Department of Pharmacy, Northwestern Medicine , Chicago, IL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1091-6130","authenticated-orcid":false,"given":"Marc H","family":"Scheetz","sequence":"additional","affiliation":[{"name":"Midwestern University College of Pharmacy Downers Grove Campus , Downers Grove, IL , USA"},{"name":"Midwestern University College of Pharmacy Downers Grove Campus, Pharmacometrics Center of Excellence , Downers Grove, IL , USA"},{"name":"Department of Pharmacy, Northwestern Medicine , Chicago, IL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen K","family":"Donnelly","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University , Chicago, IL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Donayre","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University , Chicago, IL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjia","family":"Kang","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University , Chicago, IL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estefani","family":"Diaz","sequence":"additional","affiliation":[{"name":"Robert H. 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