{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T18:09:14Z","timestamp":1784570954660,"version":"3.55.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T00:00:00Z","timestamp":1660348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"National Research Program \u2018Antimicrobial Resistance\u2019","award":["407240_167083"],"award-info":[{"award-number":["407240_167083"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Antimicrobial drugs are frequently administered in veal calves, but investigations on associations with antimicrobial susceptibility of bacteria are scarce and convey partly contradictory findings. The aim of this study was to investigate associations of antimicrobial use (AMU) during the fattening period with antimicrobial susceptibility shortly before slaughter.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Detailed treatment data of 1905 veal calves from 38 farms were collected prospectively during monthly farm visits for 1\u2005year (n\u200a=\u200a1864 treatments, n\u200a=\u200a535 visits); 1582 Escherichia coli, 1059 Pasteurella multocida and 315 Mannheimia haemolytica were isolated from rectal and nasopharyngeal swabs collected before slaughter and subjected to antimicrobial susceptibility testing by microdilution. Associations of antimicrobial treatments with resistant isolates were investigated at the calf level.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Associations of AMU with antimicrobial resistance were observed using generalized linear models. For E. coli, the odds of being resistant were increased with increased AMU (OR 1.36 when number of treatments &amp;gt;1, P\u200a=\u200a0.066). Use of tetracyclines was associated with resistance to tetracycline (OR 1.86, P\u200a&amp;lt;\u200a0.001) and use of penicillins was associated with resistance to ampicillin (OR 1.66, P\u200a=\u200a0.014). No significant associations were observed for P. multocida (use of aminoglycosides: OR 3.66 for resistance to spectinomycin, P\u200a=\u200a0.074). For M. haemolytica, the odds of being resistant were increased with increased AMU (OR 4.63, P\u200a&amp;lt;\u200a0.001), and use of tetracyclines was associated with resistance to tetracycline (OR 6.49, P\u200a&amp;lt;\u200a0.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Occurrence of resistant bacteria shortly before slaughter was associated with AMU in veal calves. Prudent and appropriate use may contribute to limit the selection of resistant bacteria on veal farms.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkac246","type":"journal-article","created":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T06:47:00Z","timestamp":1660373220000},"page":"2859-2866","source":"Crossref","is-referenced-by-count":9,"title":["Associations of antimicrobial use with antimicrobial susceptibility at the calf level in bacteria isolated from the respiratory and digestive tracts of veal calves before slaughter"],"prefix":"10.1093","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2594-007X","authenticated-orcid":false,"given":"Jens","family":"Becker","sequence":"first","affiliation":[{"name":"Clinic for Ruminants, Vetsuisse Faculty, University of Bern , Bremgartenstrasse 109a, 3012 Bern , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5722-9445","authenticated-orcid":false,"given":"Vincent","family":"Perreten","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Bacteriology, Vetsuisse Faculty, University of Bern , L\u00e4nggassstrasse 122, 3012 Bern , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2310-7105","authenticated-orcid":false,"given":"Gertraud","family":"Sch\u00fcpbach-Regula","sequence":"additional","affiliation":[{"name":"Veterinary Public Health Institute, Vetsuisse Faculty, University of Bern , Schwarzenburgstrasse 161, 3097 Liebefeld , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitri","family":"Stucki","sequence":"additional","affiliation":[{"name":"Clinic for Ruminants, Vetsuisse Faculty, University of Bern , Bremgartenstrasse 109a, 3012 Bern , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Steiner","sequence":"additional","affiliation":[{"name":"Clinic for Ruminants, Vetsuisse Faculty, University of Bern , Bremgartenstrasse 109a, 3012 Bern , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0191-5686","authenticated-orcid":false,"given":"Mireille","family":"Meylan","sequence":"additional","affiliation":[{"name":"Clinic for Ruminants, Vetsuisse Faculty, University of Bern , Bremgartenstrasse 109a, 3012 Bern , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,8,13]]},"reference":[{"key":"2022093019455559400_dkac246-B1","author":"WHO","year":"2014"},{"key":"2022093019455559400_dkac246-B2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.prevetmed.2016.02.002","article-title":"Antimicrobial drug use and risk factors associated with 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