{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:45:26Z","timestamp":1789573526566,"version":"build-2803163510"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T00:00:00Z","timestamp":1660348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To describe the clinical features and outcomes of infective endocarditis (IE) in pregnant women who do not inject drugs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A multinational retrospective study was performed at 14 hospitals. All definite IE episodes between January 2000 and April 2021 were included. The main outcomes were maternal mortality and pregnancy-related complications.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Twenty-five episodes of IE were included. Median age at IE diagnosis was 33.2\u2005years (IQR 28.3\u201336.6) and median gestational age was 30\u2005weeks (IQR 16\u201332). Thirteen (52%) patients had no previously known heart disease. Sixteen (64%) were native IE, 7 (28%) prosthetic and 2 (8%) cardiac implantable electronic device IE. The most common aetiologies were streptococci (n\u200a=\u200a10, 40%), staphylococci (n\u200a=\u200a5, 20%), HACEK group (n\u200a=\u200a3, 12%) and Enterococcus faecalis (n\u200a=\u200a3, 12%). Twenty (80%) patients presented at least one IE complication; the most common were heart failure (n\u200a=\u200a13, 52%) and symptomatic embolism other than stroke (n\u200a=\u200a4, 16%). Twenty-one (84%) patients had surgery indication and surgery was performed when indicated in 19 (90%). There was one maternal death and 16 (64%) patients presented pregnancy-related complications (11 patients \u22651 complication): 3 pregnancy losses, 9 urgent Caesarean sections, 2 emergency Caesarean sections, 1 fetal death, and 11 preterm births. Two patients presented a relapse during a median follow-up of 3.1\u2005years (IQR 0.6\u20137.4).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Strict medical surveillance of pregnant women with IE is required and must involve a multidisciplinary team including obstetricians and neonatologists. Furthermore, the potential risk of IE during pregnancy should never be underestimated in women with previously known underlying heart disease.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkac258","type":"journal-article","created":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T06:37:11Z","timestamp":1660372631000},"page":"2701-2705","source":"Crossref","is-referenced-by-count":8,"title":["Infective endocarditis in pregnant women without intravenous drug use: a multicentre retrospective case series"],"prefix":"10.1093","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5608-3090","authenticated-orcid":false,"given":"Laura","family":"Escol\u00e0-Verg\u00e9","sequence":"first","affiliation":[{"name":"Servei de Malalties Infeccioses, Hospital Universitari Vall d\u2019Hebron, Universitat Aut\u00f2noma de Barcelona , Barcelona , Spain"},{"name":"CIBERINFEC, ISCIII-CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9800-7152","authenticated-orcid":false,"given":"Pau","family":"Rello","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitari Vall d\u2019Hebron , Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Declerck","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Angers University Hospital , Angers , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9982-4741","authenticated-orcid":false,"given":"Vincent","family":"Dub\u00e9e","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Angers University Hospital , Angers , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9deric","family":"Rouleau","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angers University Hospital , Angers , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1079-4230","authenticated-orcid":false,"given":"Xavier","family":"Duval","sequence":"additional","affiliation":[{"name":"Infectious Diseases, CIC Inserm 1425, IAME, Bichat Hospital, APHP, Paris Cit\u00e9 University , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3899-9983","authenticated-orcid":false,"given":"Gilbert","family":"Habib","sequence":"additional","affiliation":[{"name":"Cardiology Department, La Timone Hospital, Aix Marseille University, IRD, APHM , Marseille , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8310-4512","authenticated-orcid":false,"given":"Yoan","family":"Lavie-Badie","sequence":"additional","affiliation":[{"name":"Heart Valve Center, Toulouse University Hospital , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8363-7028","authenticated-orcid":false,"given":"Guillaume","family":"Martin-Blondel","sequence":"additional","affiliation":[{"name":"Department of Infectious and Tropical Diseases, Toulouse University Hospital , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydie","family":"Porte","sequence":"additional","affiliation":[{"name":"Department of Infectious and Tropical Diseases, Toulouse University Hospital , Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2177-4318","authenticated-orcid":false,"given":"Kevin","family":"Bouiller","sequence":"additional","affiliation":[{"name":"Infectious Diseases, CHU Besancon , Besancon , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6997-598X","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Goehringer","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Nancy University Hospital , Nancy , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4129-5784","authenticated-orcid":false,"given":"Christine","family":"Selton-Suty","sequence":"additional","affiliation":[{"name":"Cardiology Department, CHU Nancy , Nancy , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5561-999X","authenticated-orcid":false,"given":"Cristiane da Cruz","family":"Lamas","sequence":"additional","affiliation":[{"name":"Infectious Diseases, Instituto Nacional de Cardiologia. Unigranrio. Instituto Nacional de Infectologia Evandro Chagas, Fiocruz , Rio de Janeiro , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Nacinovich","sequence":"additional","affiliation":[{"name":"Infectious Diseases, Instituto Cardiovascular Buenos Aires , Buenos Aires , Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3443-6115","authenticated-orcid":false,"given":"Nahema","family":"Issa","sequence":"additional","affiliation":[{"name":"Infectious Diseases and ICU, Groupe Saint-Andr\u00e9 Hospital, University Hospital , Bordeaux , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8100-6057","authenticated-orcid":false,"given":"Cl\u00e9mence","family":"Richaud","sequence":"additional","affiliation":[{"name":"Internal Medecine, Institut Mutualiste Montsouris , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2085-8525","authenticated-orcid":false,"given":"Nadjib","family":"Hammoudi","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, ACTION Study Group, INSERM UMR_S 1166, and H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re (AP-HP) , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9156-7739","authenticated-orcid":false,"given":"Francisco Jos\u00e9","family":"Barranco","sequence":"additional","affiliation":[{"name":"Maternal Fetal Medicine Unit, Department of Obstetrics, Vall d\u2019Hebron Barcelona Hospital Campus, Universitat Aut\u00f2noma de Barcelona , Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1189-2361","authenticated-orcid":false,"given":"Benito","family":"Almirante","sequence":"additional","affiliation":[{"name":"Servei de Malalties Infeccioses, Hospital Universitari Vall d\u2019Hebron, Universitat Aut\u00f2noma de Barcelona , Barcelona , Spain"},{"name":"CIBERINFEC, ISCIII-CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3617-5411","authenticated-orcid":false,"given":"Pierre","family":"Tattevin","sequence":"additional","affiliation":[{"name":"Infectious Diseases and ICU, Pontchaillou University Hospital , Rennes , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2115-344X","authenticated-orcid":false,"given":"Nuria","family":"Fern\u00e1ndez-Hidalgo","sequence":"additional","affiliation":[{"name":"Servei de Malalties Infeccioses, Hospital Universitari Vall d\u2019Hebron, Universitat Aut\u00f2noma de Barcelona , Barcelona , Spain"},{"name":"CIBERINFEC, ISCIII-CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III , 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Results of the ESC-EORP EURO-ENDO (European infective endocarditis) registry: a prospective cohort study","volume":"40","author":"Habib","year":"2019","journal-title":"Eur Heart J"},{"key":"2022093019463015300_dkac258-B11","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1016\/S0002-9378(98)70039-0","article-title":"Outcome of cardiovascular surgery and pregnancy: a systematic review of the period 1984\u20131996","volume":"179","author":"Weiss","year":"1998","journal-title":"Am J Obstet Gynecol"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jac\/article-pdf\/77\/10\/2701\/46223530\/dkac258.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jac\/article-pdf\/77\/10\/2701\/46223530\/dkac258.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T20:11:35Z","timestamp":1664568695000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article\/77\/10\/2701\/6664295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,13]]},"references-count":11,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,8,13]]},"published-print":{"date-parts":[[2022,9,30]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dkac258","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,10,3]]},"published":{"date-parts":[[2022,8,13]]}}}