{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:31:13Z","timestamp":1790613073186,"version":"4.1.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Fondo de Investigaci\u00f3n Sanitaria"},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Scynexis, Inc."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>We prospectively monitored the epidemiology and antifungal susceptibility of Candida spp. from blood cultures and intra-abdominal samples in patients admitted to hospitals in the Madrid area.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Between 2019 and 2021, we prospectively collected incident isolates [one per species, patient and compartment (blood cultures versus intra-abdominal samples)] from patients admitted to any of 16 hospitals located in Madrid. We studied the antifungal susceptibilities to amphotericin B, triazoles, micafungin, anidulafungin and ibrexafungerp following the EUCAST E.Def 7.3.2 procedure.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 2107 Candida spp. isolates (1895 patients) from blood cultures (51.7%) and intra-abdominal samples were collected. Candida albicans, the Candida glabrata complex, the Candida parapsilosis complex, Candida tropicalis and Candida krusei accounted for 96.9% of the isolates; in contrast, Candida auris was undetected. Fluconazole resistance in Candida spp. was higher in blood cultures than in intra-abdominal samples (9.1% versus 8.2%; P\u200a&amp;gt;\u200a0.05), especially for the C. parapsilosis complex (16.6% versus 3.6%, P\u200a&amp;lt;\u200a0.05), whereas echinocandin resistance tended to be lower in blood cultures (0.5% versus 1.0%; P\u200a&amp;gt;\u200a0.05). Resistance rates have risen, particularly for fluconazole in blood culture isolates, which increased sharply in 2021. Ibrexafungerp showed in vitro activity against most isolates. Species distributions and resistance rates varied among hospitals.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Whereas no C. auris isolates were detected, fluconazole-resistant C. parapsilosis isolates have been spreading across the region and this has pulled up the rate of fluconazole resistance. In contrast, the rate of echinocandin resistance continues to be low.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkac288","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T04:28:27Z","timestamp":1661747307000},"page":"3102-3109","source":"Crossref","is-referenced-by-count":35,"title":["Blood and intra-abdominal <i>Candida<\/i> spp. from a multicentre study conducted in Madrid using EUCAST: emergence of fluconazole resistance in <i>Candida parapsilosis<\/i>, low echinocandin resistance and absence of <i>Candida auris<\/i>"],"prefix":"10.1093","volume":"77","author":[{"given":"Judith","family":"D\u00edaz-Garc\u00eda","sequence":"first","affiliation":[{"name":"Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Mara\u00f1\u00f3n , Madrid , Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Mara\u00f1\u00f3n , Madrid , Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Machado","sequence":"additional","affiliation":[{"name":"Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Mara\u00f1\u00f3n , Madrid , Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Alcal\u00e1","sequence":"additional","affiliation":[{"name":"Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Mara\u00f1\u00f3n , Madrid , Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n , Madrid , Spain"},{"name":"CIBER Enfermedades Respiratorias-CIBERES (CB06\/06\/0058) , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0609-1305","authenticated-orcid":false,"given":"Elena","family":"Reigadas","sequence":"additional","affiliation":[{"name":"Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Mara\u00f1\u00f3n , Madrid , Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n , Madrid , Spain"},{"name":"CIBER Enfermedades Respiratorias-CIBERES (CB06\/06\/0058) , Madrid , Spain"},{"name":"Medicine Department, Faculty of Medicine, Universidad Complutense de Madrid , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"S\u00e1nchez-Carrillo","sequence":"additional","affiliation":[{"name":"Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Mara\u00f1\u00f3n , Madrid , Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n , Madrid , Spain"},{"name":"CIBER Enfermedades Respiratorias-CIBERES (CB06\/06\/0058) , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"P\u00e9rez-Ayala","sequence":"additional","affiliation":[{"name":"Hospital Universitario 12 de Octubre , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elia","family":"G\u00f3mez-Garc\u00eda De La Pedrosa","sequence":"additional","affiliation":[{"name":"Hospital Universitario Ram\u00f3n y Cajal , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Gonz\u00e1lez-Romo","sequence":"additional","affiliation":[{"name":"Hospital Universitario Cl\u00ednico San Carlos, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos IdISSC , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Soledad","family":"Cu\u00e9tara","sequence":"additional","affiliation":[{"name":"Hospital Universitario Severo Ochoa , Legan\u00e9s , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coral","family":"Garc\u00eda-Esteban","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Getafe , Getafe , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"Quiles-Melero","sequence":"additional","affiliation":[{"name":"Hospital Universitario La Paz , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelly Daniela","family":"Zurita","sequence":"additional","affiliation":[{"name":"Hospital Universitario de La Princesa , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Mu\u00f1oz-Algarra","sequence":"additional","affiliation":[{"name":"Hospital Universitario Puerta de Hierro , Majadahonda , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Teresa","family":"Dur\u00e1n-Valle","sequence":"additional","affiliation":[{"name":"Hospital Universitario de M\u00f3stoles , M\u00f3stoles , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A\u00edda","family":"S\u00e1nchez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Laboratorio Central de la CAM - URSalud - Hospital Infanta Sof\u00eda , San Sebasti\u00e1n de los Reyes , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5706-5583","authenticated-orcid":false,"given":"Patricia","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Mara\u00f1\u00f3n , Madrid , Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n , Madrid , Spain"},{"name":"CIBER Enfermedades Respiratorias-CIBERES (CB06\/06\/0058) , Madrid , Spain"},{"name":"Medicine Department, Faculty of Medicine, Universidad Complutense de Madrid , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6254-4570","authenticated-orcid":false,"given":"Pilar","family":"Escribano","sequence":"additional","affiliation":[{"name":"Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Mara\u00f1\u00f3n , Madrid , Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7901-8355","authenticated-orcid":false,"given":"Jes\u00fas","family":"Guinea","sequence":"additional","affiliation":[{"name":"Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Mara\u00f1\u00f3n , Madrid , Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n , Madrid , Spain"},{"name":"CIBER Enfermedades Respiratorias-CIBERES (CB06\/06\/0058) , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the CANDIMAD Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"D\u00edaz-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aina","family":"Mesquida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Alcal\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Reigadas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"S\u00e1nchez-Carrillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Escribano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Guinea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"P\u00e9rez-Ayala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosaura P\u00e9rez","family":"Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"del Carmen Vera Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elia","family":"G\u00f3mez-Garc\u00eda De La Pedrosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Gonz\u00e1lez","family":"Romo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma","family":"Merino-Amador","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Soledad","family":"Cu\u00e9tara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar Manuel Mu\u00f1oz","family":"Clemente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edctor Ant\u00f3n","family":"Berenguer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A\u00edda","family":"S\u00e1nchez-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coral","family":"Garc\u00eda-Esteban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar Cuevas","family":"Lobato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guadalupe","family":"Bernal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelly","family":"Zurita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ainhoa Guti\u00e9rrez","family":"Cobos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Mu\u00f1oz-Algarra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel S\u00e1nchez","family":"Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"Quiles-Melero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florinda San Juan","family":"Delgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Teresa","family":"Dur\u00e1n-Valle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda Gil","family":"Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo Manuel Fraile","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,8,29]]},"reference":[{"key":"2022102819182819600_dkac288-B1","doi-asserted-by":"crossref","first-page":"18026","DOI":"10.1038\/nrdp.2018.26","article-title":"Invasive candidiasis","volume":"4","author":"Pappas","year":"2018","journal-title":"Nat Rev Dis Primers"},{"key":"2022102819182819600_dkac288-B2","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1007\/s00134-015-3866-2","article-title":"A multicenter multinational study of abdominal candidiasis: epidemiology, outcomes and predictors of mortality","volume":"41","author":"Bassetti","year":"2015","journal-title":"Intensive Care Med"},{"key":"2022102819182819600_dkac288-B3","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1007\/s15010-021-01640-7","article-title":"Deciphering the epidemiology of invasive candidiasis in the intensive care unit: is it possible?","volume":"49","author":"Soulountsi","year":"2021","journal-title":"Infection"},{"key":"2022102819182819600_dkac288-B4","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1097\/QCO.0000000000000411","article-title":"Emerging multidrug-resistant Candida species","volume":"30","author":"Colombo","year":"2017","journal-title":"Curr Opin Infect Dis"},{"key":"2022102819182819600_dkac288-B5","doi-asserted-by":"crossref","first-page":"451","DOI":"10.3390\/jof8050451","article-title":"Impact of the COVID-19 pandemic on the clinical profile of candidemia and the incidence of fungemia due to fluconazole-resistant","volume":"8","author":"Ramos-Mart\u00ednez","year":"2022","journal-title":"Candida parapsilosis J Fungi"},{"key":"2022102819182819600_dkac288-B6","doi-asserted-by":"crossref","first-page":"e0146909","DOI":"10.1371\/journal.pone.0146909","article-title":"Epidemiology and microbiologic characterization of nosocomial candidemia from a Brazilian national surveillance program","volume":"11","author":"Doi","year":"2016","journal-title":"PLoS One"},{"key":"2022102819182819600_dkac288-B7","first-page":"491","article-title":"Update 2016-2018 of the nationwide Danish fungaemia surveillance study: epidemiologic changes in a 15-year perspective","volume":"2021","author":"Risum","journal-title":"J Fungi"},{"key":"2022102819182819600_dkac288-B8","first-page":"841","article-title":"Nationwide study of candidemia, antifungal use, and antifungal drug resistance in Iceland, 2000 to 2011","volume":"51","author":"Asmundsdottir","year":"2013","journal-title":"J Fungi"},{"key":"2022102819182819600_dkac288-B9","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1128\/AAC.02155-13","article-title":"Molecular identification and antifungal susceptibility of yeast isolates causing fungemia collected in a population-based study in Spain in 2010 and 2011","volume":"58","author":"Guinea","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"2022102819182819600_dkac288-B10","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.diagmicrobio.2014.05.021","article-title":"Sentinel surveillance of invasive candidiasis in Spain: epidemiology and antifungal susceptibility","volume":"81","author":"Nieto","year":"2015","journal-title":"Diagn Microbiol Infect Dis"},{"key":"2022102819182819600_dkac288-B11","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/myc.12781","article-title":"An outbreak due to Candida auris with prolonged colonisation and candidaemia in a tertiary care European hospital","volume":"61","author":"Ruiz-Gait\u00e1n","year":"2018","journal-title":"Mycoses"},{"key":"2022102819182819600_dkac288-B12","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.redar.2020.10.013","article-title":"Analysis of Candida auris candidemia cases in an intensive care unit of a tertiary hospital","volume":"68","author":"Ferrer G\u00f3mez","year":"2021","journal-title":"Rev Esp Anestesiol Reanim"},{"key":"2022102819182819600_dkac288-B13","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.eimc.2017.07.003","article-title":"Candidemia and colonization by Candida auris, a diagnostic challenge","volume":"36","author":"Vi\u00f1uela-Sandoval","year":"2018","journal-title":"Enferm Infecc Microbiol Clin"},{"key":"2022102819182819600_dkac288-B14","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3390\/jof8030305","article-title":"Incidence of candidemia is higher in COVID-19 versus non-COVID-19 patients, but not driven by intrahospital transmission","volume":"8","author":"Machado","year":"2022","journal-title":"J Fungi"},{"key":"2022102819182819600_dkac288-B15","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/s40121-021-00585-6","article-title":"Risk factors for intra-abdominal candidiasis in intensive care units: results from EUCANDICU study","volume":"11","author":"Bassetti","year":"2022","journal-title":"Infect Dis Ther"},{"key":"2022102819182819600_dkac288-B16","doi-asserted-by":"crossref","first-page":"e0124921","DOI":"10.1128\/AAC.01249-21","article-title":"Antifungal susceptibility testing identifies the abdominal cavity as a source of Candida glabrata-resistant isolates","volume":"65","author":"D\u00edaz-Garc\u00eda","year":"2021","journal-title":"Antimicrob Agents Chemother"},{"key":"2022102819182819600_dkac288-B17","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1128\/JCM.00118-16","article-title":"Evaluation of fluorescent capillary electrophoresis for rapid identification of Candida fungal infections","volume":"54","author":"Obru\u010dov\u00e1","year":"2016","journal-title":"J Clin Microbiol"},{"key":"2022102819182819600_dkac288-B18","author":"Arendrup","year":"2020"},{"key":"2022102819182819600_dkac288-B19","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.cmi.2021.09.030","article-title":"In vitro activity of ibrexafungerp against Candida species isolated from blood cultures. Determination of wild-type populations using the EUCAST method","volume":"28","author":"Mesquida","year":"2022","journal-title":"Clin Microbiol Infect"},{"key":"2022102819182819600_dkac288-B20","doi-asserted-by":"crossref","first-page":"3570","DOI":"10.1128\/AAC.04922-14","article-title":"Implication of Candida parapsilosis FKS1 and FKS2 mutations in reduced echinocandin susceptibility","volume":"59","author":"Mart\u00ed-Carrizosa","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"2022102819182819600_dkac288-B21","doi-asserted-by":"crossref","first-page":"e01827-20","DOI":"10.1128\/AAC.01827-20","article-title":"Monitoring the epidemiology and antifungal resistance of yeasts causing fungemia in a tertiary care hospital in Madrid, Spain: any relevant changes in the last 13 years?","volume":"65","author":"D\u00edaz-Garc\u00eda","year":"2021","journal-title":"Antimicrob Agents Chemother"},{"key":"2022102819182819600_dkac288-B22","doi-asserted-by":"crossref","first-page":"6581","DOI":"10.1128\/AAC.01177-15","article-title":"Candida parapsilosis resistance to fluconazole: molecular mechanisms and in vivo impact in infected Galleria mellonella larvae","volume":"59","author":"Souza","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"2022102819182819600_dkac288-B23","doi-asserted-by":"crossref","first-page":"4769","DOI":"10.1128\/AAC.00477-13","article-title":"Candida tropicalis antifungal cross-resistance is related to different azole target (Erg11p) modifications","volume":"57","author":"Forastiero","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"2022102819182819600_dkac288-B24","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/s15010-016-0951-6","article-title":"CAND-LO 2014-15 study: changing epidemiology of candidemia in Lombardy (Italy)","volume":"44","author":"Prigitano","year":"2016","journal-title":"Infection"},{"key":"2022102819182819600_dkac288-B25","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.cmi.2022.02.025","article-title":"Fluconazole-resistant Candida parapsilosis clonally related genotypes: first report proving the presence of endemic isolates harbouring the Y132F ERG11 gene substitution in Spain","volume":"28","author":"Alcoceba","year":"2022","journal-title":"Clin Microbiol Infect"},{"key":"2022102819182819600_dkac288-B26","doi-asserted-by":"crossref","first-page":"e0071022","DOI":"10.1128\/aac.00710-22","article-title":"Evidence of fluconazole-resistant Candida parapsilosis genotypes spreading across hospitals located in Madrid, Spain and harboring the Y132F ERG11p substitution","author":"D\u00edaz-Garc\u00eda","year":"2022","journal-title":"Antimicrob Agents Chemother"},{"key":"2022102819182819600_dkac288-B27","doi-asserted-by":"crossref","first-page":"1154.e5","DOI":"10.1016\/j.cmi.2022.04.003","article-title":"\u0394F659 and F659S substitutions at the HS1 of FKS2 gene, along with E655A and W715L upstream and downstream substitutions, correlate with high ibrexafungerp MICs against Candida glabrata","volume":"28","author":"Mesquida","year":"2022","journal-title":"Clin Microbiol Infect"},{"key":"2022102819182819600_dkac288-B28","doi-asserted-by":"crossref","first-page":"e00161-17","DOI":"10.1128\/AAC.00161-17","article-title":"Differential activity of the oral glucan synthase inhibitor scy-078 against wild-type and echinocandin-resistant strains of Candida species","volume":"61","author":"Pfaller","year":"2017","journal-title":"Antimicrob Agents Chemother"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jac\/article-pdf\/77\/11\/3102\/46680448\/dkac288.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jac\/article-pdf\/77\/11\/3102\/46680448\/dkac288.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T19:22:27Z","timestamp":1666984947000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article\/77\/11\/3102\/6678135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,29]]},"references-count":28,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,8,29]]},"published-print":{"date-parts":[[2022,10,28]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dkac288","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,11,2]]},"published":{"date-parts":[[2022,8,29]]}}}