{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:42:25Z","timestamp":1790300545977,"version":"4.1.0"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T00:00:00Z","timestamp":1669075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Chantal BIYA International Reference Centre for research on HIV\/AIDS prevention and management"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>We evaluated the HIV-1 capsid genetic variability and lenacapavir drug resistance-associated mutations (DRMs) among drug-naive individuals across HIV-1 clades.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A total of 2031 HIV-1 sequences from drug-naive patients were analysed for capsid amino acid modification and the prevalence of lenacapavir DRMs. Amino acid positions with &amp;lt;5% variability were considered as conserved and variability was analysed by HIV-1 clades.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Overall, 63% (148\/232) of amino acid positions were conserved in the capsid protein. Of note, conservation was consistent in specific binding residues of cellular factors involved in viral replication [CypA (G89, P90), CPSF6 (Q4, N57, N74, A77, K182) and TRIM-NUP153 (R143)], while N183 (12.31%) was the only non-conserved lenacapavir binding residue. The overall prevalence (95% CI) of lenacapavir DRMs was 0.14% (0.05\u20130.44) (3\/2031), with M66I (0.05%) and Q67H (0.05%) observed in subtype C, and T107N (0.05%) observed in CRF01_AE. Moreover, polymorphic mutations M66C (n\u200a=\u200a85; 4.18%), Q67K (n\u200a=\u200a78; 3.84%), K70R (n\u200a=\u200a7; 0.34%), N74R (n\u200a=\u200a57; 2.81%) and T107L (n\u200a=\u200a82; 4.03%) were observed at lenacapavir resistance-associated positions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The low level of lenacapavir DRMs (&amp;lt;1%) supports its predicted effectiveness for treatment and prevention, regardless of HIV-1 clades. The established conserved regions hence serve as a hallmark for the surveillance of novel mutations potentially relevant for lenacapavir resistance.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkac388","type":"journal-article","created":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T03:35:52Z","timestamp":1669088152000},"page":"272-275","source":"Crossref","is-referenced-by-count":31,"title":["Evaluation of HIV-1 capsid genetic variability and lenacapavir (GS-6207) drug resistance-associated mutations according to viral clades among drug-naive individuals"],"prefix":"10.1093","volume":"78","author":[{"given":"Alex Durand","family":"Nka","sequence":"first","affiliation":[{"name":"Chantal BIYA International Reference Centre for research on HIV\/AIDS prevention and management (CIRCB) , Yaound\u00e9 , Cameroon"},{"name":"University of Rome \u2018Tor Vergata\u2019 , Rome , Italy"},{"name":"Evangelical University of Cameroon , Bandjoun , 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