{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T11:26:53Z","timestamp":1770463613322,"version":"3.49.0"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,12,31]],"date-time":"2022-12-31T00:00:00Z","timestamp":1672444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Guangdong Basic and Applied Basic Research Foundation","doi-asserted-by":"crossref","award":["2019B1515120003"],"award-info":[{"award-number":["2019B1515120003"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81573211"],"award-info":[{"award-number":["81573211"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["SZSM201811071"],"award-info":[{"award-number":["SZSM201811071"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shenzhen Key Medical Discipline Construction Fund","award":["SZXK064"],"award-info":[{"award-number":["SZXK064"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>In recent years, integrase strand transfer inhibitor (INSTI)-containing regimens have been increasingly adopted in treatment for HIV\/AIDS and promoted as non-occupational post-exposure prophylaxis in China. This study aims to describe the prevalence of resistance to integrase and drug resistance mutations (DRMs) among ART-naive patients in Shenzhen, China.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Serum samples and demographic information were collected from newly reported ART-naive patients in Shenzhen in 2020. The study sequenced the coding sequence of the HIV-1 integrase gene and determined the DRMs.\u200b<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In this study, 1682 newly reported cases were included and 1071 of them were successfully sequenced finally. The prevalence of primary drug resistance was 1.77%, with 19 samples showing varying degrees of resistance to INSTIs. The study detected six major DRMs in 16 individuals and eight accessory DRMs in 24 individuals. The prevalence of transmitted drug resistance (TDR) mutations was 1.21%, with five transmitted mutations detected in 13 individuals. The prevalence of drug resistance to raltegravir and elvitegravir was statistically higher than to bictegravir, cabotegravir and dolutegravir.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The prevalence of INSTI resistance in Shenzhen in 2020 was relatively high. \u200bContinued surveillance for resistance to INSTIs is recommended and treatment regimens should be adopted based on the pattern of resistance to INSTIs. \u200bDolutegravir or bictegravir is first recommended when considering INSTIs as treatment regimens.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkac442","type":"journal-article","created":{"date-parts":[[2022,12,31]],"date-time":"2022-12-31T06:01:47Z","timestamp":1672466507000},"page":"546-549","source":"Crossref","is-referenced-by-count":7,"title":["Primary resistance to integrase inhibitors in Shenzhen"],"prefix":"10.1093","volume":"78","author":[{"given":"Yue","family":"Zhu","sequence":"first","affiliation":[{"name":"School of Public Health, Shantou University , Shantou , China"},{"name":"Department of HIV\/AIDS Control and Prevention, Shenzhen Center for Disease Control and Prevention , Shenzhen , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanmei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of HIV\/AIDS Control and Prevention, Shenzhen Center for Disease Control and Prevention , Shenzhen , China"},{"name":"School of Public Health, Shanxi Medical University , Taiyuan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenli","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of HIV\/AIDS Control and Prevention, Shenzhen Center for Disease Control and Prevention , Shenzhen , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of HIV\/AIDS Control and Prevention, Shenzhen Center for Disease Control and Prevention , Shenzhen , China"},{"name":"School of Public Health, University of South China , Hengyang , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of HIV\/AIDS Control and Prevention, Shenzhen Center for Disease Control and Prevention , Shenzhen , China"},{"name":"School of Public Health, University of South China , Hengyang , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of HIV\/AIDS Control and Prevention, Shenzhen Center for Disease Control and Prevention , Shenzhen , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The Third People\u2019s Hospital of Shenzhen , Shenzhen , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The Third People\u2019s Hospital of Shenzhen , Shenzhen , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaochu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of HIV\/AIDS Control and Prevention, Shenzhen Center for Disease Control and Prevention , Shenzhen , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of HIV\/AIDS Control and Prevention, Shenzhen Center for Disease Control and Prevention , Shenzhen , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of HIV\/AIDS Control and Prevention, Shenzhen Center for Disease Control and Prevention , Shenzhen , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingguang","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of HIV\/AIDS Control and Prevention, Shenzhen Center for Disease Control and Prevention , Shenzhen , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijuan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of HIV\/AIDS Control and Prevention, Shenzhen Center for Disease Control and Prevention , Shenzhen , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"He","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The Third People\u2019s Hospital of Shenzhen , Shenzhen , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liumei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The Third People\u2019s Hospital of Shenzhen , Shenzhen , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengrong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of HIV\/AIDS Control and Prevention, Shenzhen Center for Disease Control and Prevention , Shenzhen , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3266-0594","authenticated-orcid":false,"given":"Jin","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Public Health, Shantou University , Shantou , China"},{"name":"Department of HIV\/AIDS Control and Prevention, Shenzhen Center for Disease Control and Prevention , Shenzhen , China"},{"name":"School of Public Health, Shanxi Medical University , Taiyuan , 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of current drugs, recent advances and drug resistance","volume":"57","author":"Mbhele","year":"2021","journal-title":"Int J Antimicrob Agents"},{"key":"2023020108211070200_dkac442-B4","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1097\/QAD.0000000000002282","article-title":"Lack of HIV-1 integrase inhibitor resistance among 392 antiretroviral-na\u00efve individuals in a tertiary care hospital in Beijing, China","volume":"33","author":"Liu","year":"2019","journal-title":"AIDS"},{"key":"2023020108211070200_dkac442-B5","first-page":"1321","article-title":"Drug research progress of antiretroviral therapy in AIDS patients","volume":"28","author":"Liang","year":"2022","journal-title":"Chin J AIDS STD"},{"key":"2023020108211070200_dkac442-B6","first-page":"31","volume-title":"Med J Peking Union Med College Hospital","author":"Acquired Immunodeficiency Syndrome and Hepatitis C Professional Group CMA, Chinese Center for Disease Control and 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