{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:20:35Z","timestamp":1792455635409,"version":"4.5.0"},"reference-count":69,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T00:00:00Z","timestamp":1674172800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100007135","name":"University of Tennessee","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007135","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Overseas Research Scholar Program in Osaka Prefecture University"},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["201709110035"],"award-info":[{"award-number":["201709110035"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000199","name":"United States Department of Agriculture","doi-asserted-by":"publisher","award":["2018-67015-27475"],"award-info":[{"award-number":["2018-67015-27475"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Polymyxins, including colistin, are the drugs of last resort to treat MDR bacterial infections in humans. In-depth understanding of the molecular basis and regulation of polymyxin resistance would provide new therapeutic opportunities to combat increasing polymyxin resistance. Here we aimed to identify novel targets that are crucial for polymyxin resistance using Escherichia coli BL21(DE3), a unique colistin-resistant model strain.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>BL21(DE3) was subjected to random transposon mutagenesis for screening colistin-susceptible mutants. The insertion sites of desired mutants were mapped; the key genes of interest were also inactivated in different strains to examine functional conservation. Specific genes in the known PmrAB and PhoPQ regulatory network were inactivated to examine crosstalk among different pathways. Lipid A species and membrane phospholipids were analysed by normal phase LC\/MS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among eight mutants with increased susceptibility to colistin, five mutants contained different mutations in three genes (rseP, degS and surA) that belong to the RpoE stress response pathway. Inactivation of rpoE, pmrB, eptA or pmrD led to significantly increased susceptibility to colistin; however, inactivation of phoQ or eptB did not change colistin MIC. RpoE mutation in different E. coli and Salmonella resistant strains all led to significant reduction in colistin MIC (16\u201332-fold). Inactivation of rpoE did not change the lipid A profile but significantly altered the phospholipid profile.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Inactivation of the important members of the RpoE regulon in polymyxin-resistant strains led to a drastic reduction in polymyxin MIC and an increase of lysophospholipids with no change in lipid A modifications.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkad003","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T05:42:00Z","timestamp":1674193320000},"page":"732-746","source":"Crossref","is-referenced-by-count":12,"title":["Critical role of the RpoE stress response pathway in polymyxin resistance of <i>Escherichia coli<\/i>"],"prefix":"10.1093","volume":"78","author":[{"given":"Ximin","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Animal Science, The University of Tennessee , Knoxville, TN , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Hinenoya","sequence":"additional","affiliation":[{"name":"Department of Animal Science, The University of Tennessee , Knoxville, TN , USA"},{"name":"Graduate School of Veterinary Science, Osaka Metropolitan University , Osaka , Japan"},{"name":"Asian Health Science Research Institute, Osaka Metropolitan University , Osaka , Japan"},{"name":"Osaka International Research Center for Infectious Diseases, Osaka Metropolitan University , Osaka , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqiang","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Duke University Medical Center , Durham, NC , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuzhou","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Animal Science, The University of Tennessee , Knoxville, TN , USA"},{"name":"Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0377-1030","authenticated-orcid":false,"given":"Jun","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Animal Science, The University of Tennessee , Knoxville, TN , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,1,20]]},"reference":[{"key":"2024012023464112500_dkad003-B1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S1473-3099(06)70580-1","article-title":"Colistin: the re-emerging antibiotic for multidrug-resistant Gram-negative bacterial infections","volume":"6","author":"Li","year":"2006","journal-title":"Lancet Infect 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