{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T04:30:30Z","timestamp":1771389030951,"version":"3.50.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T00:00:00Z","timestamp":1674172800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Initiating same-day ART for newly HIV-diagnosed individuals reduces secondary HIV transmissions and the risk of them being lost to follow-up between diagnosis and initiation of ART.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The FAST study was a national, prospective, single-arm study assessing the efficacy, safety and feasibility of bictegravir\/emtricitabine\/tenofovir alafenamide (BIC\/FTC\/TAF) in a same-day initiation model. ART had to be started on the first medical appointment, before any laboratory results were available. Participants completed a self-administered questionnaire at each visit including a HIV anxiety 5-point Likert scale. The primary outcome was the proportion of participants in the ITT population with plasma HIV RNA (pVL)\u200a&amp;lt;\u200a50 copies\/mL at Week (W) 24 using the FDA Snapshot algorithm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 112 participants were included in the ITT population. During follow-up, seven participants discontinued the study drug but remained on the study, and seven others discontinued follow-up. According to FDA Snapshot analysis, at W24 and W48, 90\/112, (80.4%; 95% CI: 71.8\u201387.3) and 95\/112 (84.8%; 95% CI: 76.8\u201390.9) of participants achieved pVL\u200a&amp;lt;\u200a50 copies\/mL, respectively. The protocol-defined virological failure (PDVF, 2 consecutive pVL\u200a\u2265\u200a50 copies\/mL as of W24) was observed in 11\/112 (9.8%) at W24 and 14\/112 (12.5%) at W48. No emergent resistance-associated mutation was detected in those with PDVF at W24 and W48. BIC\/FTC\/TAF was well tolerated through to W48, with a low incidence of grade 3\u20134 adverse events (15\/100 person-years). Patient opinion of same-day treatment initiation and continuing BIC\/FTC\/TAF was very favourable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results suggest that BIC\/FTC\/TAF is safe, effective and well accepted for same-day initiation.<\/jats:p><\/jats:sec>","DOI":"10.1093\/jac\/dkad008","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T06:18:26Z","timestamp":1674195506000},"page":"769-778","source":"Crossref","is-referenced-by-count":15,"title":["Same-day initiation of bictegravir\/emtricitabine\/tenofovir alafenamide: Week 48 results of the FAST study\u2014IMEA 055"],"prefix":"10.1093","volume":"78","author":[{"given":"Antoine","family":"Bachelard","sequence":"first","affiliation":[{"name":"AP-HP Nord, Department of Infectious and Tropical Diseases, Bichat Claude-Bernard University Hospital , Paris , 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