{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:36:57Z","timestamp":1790696217129,"version":"4.1.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T00:00:00Z","timestamp":1675987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"crossref","award":["RD16\/0016\/0003"],"award-info":[{"award-number":["RD16\/0016\/0003"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red","award":["CB21\/13\/00054"],"award-info":[{"award-number":["CB21\/13\/00054"]}]},{"name":"Contratos Predoctorales de Formaci\u00f3n en Investigaci\u00f3n","award":["FI19\/00315"],"award-info":[{"award-number":["FI19\/00315"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Several countries have recently reported the detection of ESBL-producing Shigella sonnei associated with transmission among MSM. In a previous study by our group, 2.8% of Shigella spp. obtained from MSM in Barcelona between 2015 and 2019 were ESBL producers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To describe and characterize the emerging ESBL-producing Shigella spp. associated with sexual transmission among MSM detected from 2020 to 2021 in Barcelona, elucidating their connectivity with contemporaneous ESBL-producing Shigella spp. from other countries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 2020 to 2021, we identified that among MSM, 68% of S. sonnei were XDR harbouring blaCTX-M-27 and 14% of Shigella flexneri were MDR harbouring blaCTX-M-27. WGS analysis showed that the ESBL-producing S. sonnei were part of a monophyletic cluster, which included isolates responsible for the prolonged outbreak occurring in the UK. Our data also reveal the first emergence and clonal dissemination of ESBL-producing and fluoroquinolone-resistant S. flexneri 2a among MSM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We report an increasing trend of antimicrobial resistance in Shigella spp. among MSM in Barcelona since 2021, mainly as a consequence of the dissemination of XDR ESBL-producing S. sonnei, previously reported in the UK. These results highlight the importance of international collaborative surveillance of MDR\/XDR S. sonnei and S. flexneri for rapid identification of their emergence and the prevention of the transmission of these pathogens.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jac\/dkad031","type":"journal-article","created":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T10:04:57Z","timestamp":1674554697000},"page":"975-982","source":"Crossref","is-referenced-by-count":29,"title":["Increasing trend of antimicrobial resistance in\n                    <i>Shigella<\/i>\n                    associated with MSM transmission in Barcelona, 2020\u201321: outbreak of XRD\n                    <i>Shigella sonnei<\/i>\n                    and dissemination of ESBL-producing\n                    <i>Shigella flexneri<\/i>"],"prefix":"10.1093","volume":"78","author":[{"given":"Albert","family":"Moreno-Mingorance","sequence":"first","affiliation":[{"name":"Vall d\u2019Hebron Institut de 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