{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:47:07Z","timestamp":1791920827812,"version":"4.3.4"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:00:00Z","timestamp":1682467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Red Tem\u00e1tica de Investigaci\u00f3n Cooperativa en Sida","award":["RD06\/006"],"award-info":[{"award-number":["RD06\/006"]}]},{"name":"Red Tem\u00e1tica de Investigaci\u00f3n Cooperativa en Sida","award":["RD12\/0017\/0018"],"award-info":[{"award-number":["RD12\/0017\/0018"]}]},{"name":"Red Tem\u00e1tica de Investigaci\u00f3n Cooperativa en Sida","award":["RD16\/0002\/0006"],"award-info":[{"award-number":["RD16\/0002\/0006"]}]},{"name":"ISCIII-Subdirecci\u00f3n General de Evaluaci\u00f3n"},{"DOI":"10.13039\/501100008530","name":"Fondo Europeo de Desarrollo Regional","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010877","name":"ViiV Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010877","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To assess the effectiveness and tolerability of dolutegravir (DTG)\/lamivudine (3TC) among treatment-naive and virologically suppressed treatment-experienced individuals in the multicentre cohort of the Spanish HIV\/AIDS Research Network (CoRIS) during the years 2018\u20132021.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We used multivariable regression models to compare viral suppression (VS) [HIV RNA viral load (VL) &amp;lt;50 copies\/mL] and the change in CD4 cell counts at 24 and 48 (\u00b112) weeks after initiation with dolutegravir\/lamivudine or other first-line ART regimens.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We included 2160 treatment-naive subjects, among whom 401 (18.6%) started with dolutegravir\/lamivudine. The remaining subjects started bictegravir (BIC)\/emtricitabine (FTC)\/tenofovir alafenamide (TAF) (n\u200a=\u200a949, 43.9%), DTG\u200a+\u200aFTC\/tenofovir disoproxil fumarate (TDF) (n\u200a=\u200a282, 13.1%), DTG\/3TC\/abacavir (ABC) (n\u200a=\u200a255, 11.8%), darunavir (DRV)\/cobicistat(COBI)\/FTC\/TAF (n\u200a=\u200a147, 6.8%) and elvitegravir (EVG)\/COBI\/FTC\/TAF (n\u200a=\u200a126, 5.8%). At 24 and 48 weeks after starting dolutegravir\/lamivudine, 91.4% and 93.8% of the subjects, respectively, achieved VS. The probability of achieving VS with dolutegravir\/lamivudine was not significantly different compared with any other regimen at 24 or 48 weeks, with the exception of a lower chance of achieving VS at 24 weeks for DRV\/COBI\/FTC\/TAF (adjusted OR: 0.47; 95% CI: 0.30\u20130.74) compared with dolutegravir\/lamivudine.<\/jats:p>\n                  <jats:p>For the analysis of treatment-experienced virally suppressed subjects we included 1456 individuals who switched to dolutegravir\/lamivudine, among whom 97.4% and 95.5% maintained VS at 24 and 48 weeks, respectively. During the first 48 weeks after dolutegravir\/lamivudine initiation, 1.0% of treatment-naive and 1.5% of treatment-experienced subjects discontinued dolutegravir\/lamivudine due to an adverse event.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In this large multicentre cohort, effectiveness and tolerability of dolutegravir\/lamivudine were high among treatment-naive and treatment-experienced subjects.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkad102","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T17:35:03Z","timestamp":1682530503000},"page":"1423-1432","source":"Crossref","is-referenced-by-count":35,"title":["Effectiveness and tolerability of dolutegravir\/lamivudine for the treatment of HIV-1 infection in clinical 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