{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T01:51:54Z","timestamp":1768096314247,"version":"3.49.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T00:00:00Z","timestamp":1682553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100003323","name":"ANRS","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003323","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Emerging Infectious Diseases"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n In a 4 days\/week (4\/7 days) maintenance strategy (ANRS-170 QUATUOR trial), the virological impact of an intermittent strategy was assessed by ultrasensitive virological analyses of reservoirs and resistance.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n HIV-1 total DNA, ultra-sensitive plasma viral load (USpVL) and semen VL were measured in the first 121 participants. Sanger and ultra-deep sequencing (UDS) were performed on the HIV-1 genome (Illumina technology) according to the ANRS consensus. A generalized estimation equation with a Poisson distribution was used to compare changes in the proportion of residual viraemia, detectable semen HIV RNA and HIV DNA within and between the two groups over time.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The proportion of participants with residual viraemia at Day 0 (D0) and Week 48 (W48) was 16.7% and 25.0% in the 4\/7 days group and 22.4% and 29.7% in the 7\/7 days group, respectively (+8.3% versus +7.3%, P = 0.971). The proportion of detectable DNA (&gt;40 copies\/106 cells) at D0 and W48 was 53.7% and 57.4% in the 4\/7 days group and 56.1% and 51.8% in the 7\/7 days group, respectively (+3.7% versus \u22124.3%, P = 0.358). Semen HIV RNA was detectable (\u2265100 copies\/mL) in 2.2% of participants at D0 and 4.5% at W48 in the 4\/7 days group versus 6.1% and 9.1% in the 7\/7 days group, respectively (+2.3% versus +3.0%, P = 0.743). Emerging resistance at failure was more frequent in the 4\/7 days group detected by Sanger sequencing: 3\/6 participants versus 1\/4 in the 7\/7 days group, and similar with the UDS assay: 5\/6 versus 4\/4, respectively.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n These findings support the potency of a 4\/7 days maintenance strategy on virological suppression at the reservoirs and emergent resistance level, including minority variants.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/jac\/dkad119","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T20:38:48Z","timestamp":1682627928000},"page":"1510-1521","source":"Crossref","is-referenced-by-count":4,"title":["Four days\/week antiretroviral maintenance strategy (ANRS 170 QUATUOR): substudies of reservoirs and ultrasensitive drug resistance"],"prefix":"10.1093","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3378-250X","authenticated-orcid":false,"given":"Sidonie","family":"Lambert-Niclot","sequence":"first","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d\u2019\u00c9pid\u00e9miologie et de Sant\u00e9 Publique (IPLESP) , 184 rue du Faubourg Saint-Antoine, 75571 Cedex 12, Paris , France"},{"name":"AP-HP H\u00f4pital Saint-Antoine, Laboratoire de Virologie , Paris , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9139-0010","authenticated-orcid":false,"given":"Basma","family":"Abdi","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d\u2019\u00c9pid\u00e9miologie et de Sant\u00e9 Publique (IPLESP) , 184 rue du Faubourg Saint-Antoine, 75571 Cedex 12, Paris , France"},{"name":"AP-HP H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Virology Department , Paris , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Bellet","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d\u2019\u00c9pid\u00e9miologie et de Sant\u00e9 Publique (IPLESP) , 184 rue du Faubourg Saint-Antoine, 75571 Cedex 12, Paris , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Djeneba","family":"Fofana","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d\u2019\u00c9pid\u00e9miologie et de Sant\u00e9 Publique (IPLESP) , 184 rue du Faubourg Saint-Antoine, 75571 Cedex 12, Paris , France"},{"name":"AP-HP H\u00f4pital Saint-Antoine, Laboratoire de Virologie , Paris , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"De Truchis","sequence":"additional","affiliation":[{"name":"H\u00f4pitaux Universitaires Paris-Ile de France-Ouest, H\u00f4pital Raymond Poincar\u00e9 APHP, Universit\u00e9 Versailles-Saint-Quentin, France, Infectious Diseases Department , Garches , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karine","family":"Amat","sequence":"additional","affiliation":[{"name":"Institut de M\u00e9decine et Epid\u00e9miologie Appliqu\u00e9e, H\u00f4pital Bichat, Universit\u00e9 Paris 7 , Paris , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5344-9475","authenticated-orcid":false,"given":"Jean-Claude","family":"Alvarez","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pharmacologie-Toxicologie, H\u00f4pital R Poincar\u00e9 APHP, Inserm U-1173, Universit\u00e9 Versailles-Saint-Quentin , Garches , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laure","family":"Surgers","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d\u2019\u00c9pid\u00e9miologie et de Sant\u00e9 Publique (IPLESP) , 184 rue du Faubourg Saint-Antoine, 75571 Cedex 12, Paris , France"},{"name":"GHU APHP. Sorbonne Universit\u00e9, Service des Maladies Infectieuses et Tropicales, H\u00f4pital Saint-Antoine , F75012, Paris , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clothilde","family":"Allavena","sequence":"additional","affiliation":[{"name":"H\u00f4pital H\u00f4tel-Dieu, Infectious Diseases Department , Nantes , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Zaegell-Faucher","sequence":"additional","affiliation":[{"name":"CHU Sainte-Marguerite, Assistance Publique H\u00f4pitaux de Marseille, Infectious Diseases Department , Marseille , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Morlat","sequence":"additional","affiliation":[{"name":"H\u00f4pital Saint Andr\u00e9, Internal Medicine and Infectious Diseases Department, CHU, Universit\u00e9 de Bordeaux , Bordeaux , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0047-0101","authenticated-orcid":false,"given":"Romain","family":"Palich","sequence":"additional","affiliation":[{"name":"AP-HP H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Infectious Diseases Department , Paris , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9verine","family":"Gibowski","sequence":"additional","affiliation":[{"name":"ANRS, MIE Maladies Infectieuses Emergentes , Paris , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0765-0869","authenticated-orcid":false,"given":"Dominique","family":"Costagliola","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d\u2019\u00c9pid\u00e9miologie et de Sant\u00e9 Publique (IPLESP) , 184 rue du Faubourg Saint-Antoine, 75571 Cedex 12, Paris , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre-Marie","family":"Girard","sequence":"additional","affiliation":[{"name":"GHU APHP. Sorbonne Universit\u00e9, Service des Maladies Infectieuses et Tropicales, H\u00f4pital Saint-Antoine , F75012, Paris , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Landman","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Department, IAME, UMR 1137, INSERM, Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, AP-HP, H\u00f4pital Bichat, AP-HP, Infectious and Tropical Diseases , Paris , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lambert","family":"Assoumou","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d\u2019\u00c9pid\u00e9miologie et de Sant\u00e9 Publique (IPLESP) , 184 rue du Faubourg Saint-Antoine, 75571 Cedex 12, Paris , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Morand-Joubert","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d\u2019\u00c9pid\u00e9miologie et de Sant\u00e9 Publique (IPLESP) , 184 rue du Faubourg Saint-Antoine, 75571 Cedex 12, Paris , France"},{"name":"AP-HP H\u00f4pital Saint-Antoine, Laboratoire de Virologie , Paris , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the ANRS 170 QUATUOR study group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Lamaury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emeline","family":"Duvallon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Firouz\u00e9","family":"Bani-Sadr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Kmiec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Force","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Am\u00e9lie","family":"Chabrol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nouara","family":"Agher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabienne","family":"Caby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bouchra","family":"Wifaq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Patey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Fresard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amandine","family":"Gagneux-Brunon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Chirouze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudine","family":"Duvivier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9r\u00e9mie","family":"Lourenco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Violaine","family":"Tolsma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cile","family":"Janssen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Lerolle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilartxo","family":"Catalan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agathe","family":"Rami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucile","family":"De Ponthaud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Pichancourt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Safa","family":"Nasri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phanie","family":"Landowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morgane","family":"Marcou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Bottero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flory","family":"Mfutila Kaykay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Pialoux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Bouchaud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Abgrall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Gatey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliette","family":"Pavie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Salmonceron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Zucman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amina","family":"Fadli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Daniel","family":"Lelievre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romain","family":"Palich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Simon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalila","family":"Beniken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Caroline","family":"Meyohas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Gras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Cabie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathilde","family":"Pircher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Morlat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mojgam","family":"Hessamfar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Neau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Cazenave","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Genet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Fran\u00e7ois","family":"Faucher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Djamila","family":"Makhloufi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Boibieux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvie","family":"Bregigeon-Ronot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e8ne","family":"Laroche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aur\u00e9lie","family":"Sautereau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Reynes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Makinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Raffi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Bollengierstragier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alissa","family":"Naqvi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Cua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Rosenthal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Breaud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9drick","family":"Arvieux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jocelyne","family":"Vivent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodolphe","family":"Buzele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Rey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Laure","family":"Batard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis","family":"Bernard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Delobel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Piffaut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renaud","family":"Verdon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lionel","family":"Piroth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathieu","family":"Blot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascale","family":"Leclercq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Signori-Schmuck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Huleux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agn\u00e8s","family":"Meybeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"May","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mickael","family":"Delestan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Miailhes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Perpoint","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alix","family":"Greder-Belan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Bornarel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Elharrar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Aude","family":"Khuong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Poupard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Blum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Michau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carole","family":"Grand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Prazuck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Philibert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Gasse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Slama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoto","family":"Hikombo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iuliana","family":"Darasteanu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7oise","family":"Itoua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,4,27]]},"reference":[{"key":"2023060100351804100_dkad119-B1","author":"European AIDS Clinical Society"},{"key":"2023060100351804100_dkad119-B2","author":"Morlat","year":"2018"},{"key":"2023060100351804100_dkad119-B3","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1001\/jama.2022.22246","article-title":"Antiretroviral drugs for treatment and prevention of HIV infection in adults: 2022 recommendations of the International Antiviral Society-USA panel","volume":"329","author":"Gandhi","year":"2023","journal-title":"JAMA"},{"key":"2023060100351804100_dkad119-B4","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1056\/NEJMra041811","article-title":"Cardiovascular risk and body-fat abnormalities in HIV-infected adults","volume":"352","author":"Grinspoon","year":"2005","journal-title":"N Engl J Med"},{"key":"2023060100351804100_dkad119-B5","doi-asserted-by":"crossref","first-page":"e343","DOI":"10.1016\/S2352-3018(16)30010-8","article-title":"Low-dose versus standard-dose ritonavir-boosted atazanavir in virologically suppressed Thai adults with HIV (LASA): a randomised, open-label, non-inferiority trial","volume":"3","author":"Bunupuradah","year":"2016","journal-title":"Lancet HIV"},{"key":"2023060100351804100_dkad119-B6","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1093\/jac\/dky181","article-title":"Low-dose ritonavir-boosted darunavir in virologically suppressed HIV-1-infected adults: an open-label trial (ANRS 165 Darulight)","volume":"73","author":"Molina","year":"2018","journal-title":"J Antimicrob Chemother"},{"key":"2023060100351804100_dkad119-B7","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1177\/1060028018758432","article-title":"Dolutegravir dual therapy as maintenance treatment in HIV-infected patients: a review","volume":"52","author":"Boswell","year":"2018","journal-title":"Ann Pharmacother"},{"key":"2023060100351804100_dkad119-B8","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S0140-6736(17)33095-7","article-title":"Efficacy, safety, and tolerability of dolutegravir-rilpivirine for the maintenance of virological suppression in adults with HIV-1: phase 3, randomised, non-inferiority SWORD-1 and SWORD-2 studies","volume":"391","author":"Llibre","year":"2018","journal-title":"Lancet"},{"key":"2023060100351804100_dkad119-B9","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1093\/jac\/dky467","article-title":"Dolutegravir and lamivudine maintenance therapy in HIV-1 virologically suppressed patients: results of the ANRS 167 trial (LAMIDOL)","volume":"74","author":"Joly","year":"2019","journal-title":"J Antimicrob Chemother"},{"key":"2023060100351804100_dkad119-B10","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1093\/jac\/dkz224","article-title":"Dual therapy combining raltegravir with etravirine maintains a high level of viral suppression over 96 weeks in long-term experienced HIV-infected individuals over 45 years on a PI-based regimen: results from the phase II ANRS 163 ETRAL study","volume":"74","author":"Katlama","year":"2019","journal-title":"J Antimicrob Chemother"},{"key":"2023060100351804100_dkad119-B11","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1093\/cid\/ciy382","article-title":"Ultrasensitive human immunodeficiency virus type 1 viral load as a marker of treatment choice for simplification strategies","volume":"67","author":"Lambert-Niclot","year":"2018","journal-title":"Clin Infect Dis"},{"key":"2023060100351804100_dkad119-B12","doi-asserted-by":"crossref","first-page":"e421","DOI":"10.1016\/S2352-3018(16)30054-6","article-title":"Weekends-off efavirenz-based antiretroviral therapy in HIV-infected children, adolescents, and young adults (BREATHER): a randomised, open-label, non-inferiority, phase 2\/3 trial","volume":"3","author":"BREATHER (PENTA 16) Trial Group","year":"2016","journal-title":"Lancet HIV"},{"key":"2023060100351804100_dkad119-B13","doi-asserted-by":"crossref","first-page":"e10307","DOI":"10.1371\/journal.pone.0010307","article-title":"A randomized, controlled, trial of short cycle intermittent compared to continuous antiretroviral therapy for the treatment of HIV infection in Uganda","volume":"5","author":"Reynolds","year":"2010","journal-title":"PLoS One"},{"key":"2023060100351804100_dkad119-B14","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1310\/hct0801-19","article-title":"Pilot study of a novel short-cycle antiretroviral treatment interruption strategy: 48-week results of the five-days-on, two-days-off (FOTO) study","volume":"8","author":"Cohen","year":"2007","journal-title":"HIV Clin Trials"},{"key":"2023060100351804100_dkad119-B15","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1096\/fj.14-260315","article-title":"Four days a week or less on appropriate anti-HIV drug combinations provided long-term optimal maintenance in 94 patients: the ICCARRE project","volume":"29","author":"Leibowitch","year":"2015","journal-title":"FASEB J"},{"key":"2023060100351804100_dkad119-B16","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1093\/jac\/dkx434","article-title":"Four-days-a-week antiretroviral maintenance therapy in virologically controlled HIV-1-infected adults: the ANRS 162-4D trial","volume":"73","author":"de Truchis","year":"2018","journal-title":"J Antimicrob Chemother"},{"key":"2023060100351804100_dkad119-B17","doi-asserted-by":"crossref","first-page":"e79","DOI":"10.1016\/S2352-3018(21)00300-3","article-title":"A 4-days-on and 3-days-off maintenance treatment strategy for adults with HIV-1 (ANRS 170 QUATUOR): a randomised, open-label, multicentre, parallel, non-inferiority trial","volume":"9","author":"Landman","year":"2022","journal-title":"Lancet HIV"},{"key":"2023060100351804100_dkad119-B18","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1093\/jac\/dkz555","article-title":"Efficacy of intermittent short cycles of integrase inhibitor-based maintenance ART in virologically suppressed HIV patients","volume":"75","author":"Calin","year":"2020","journal-title":"J Antimicrob Chemother"},{"key":"2023060100351804100_dkad119-B19","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1093\/jac\/dku557","article-title":"Improved detection of resistance at failure to a tenofovir, emtricitabine and efavirenz regimen by ultradeep sequencing","volume":"70","author":"Todesco","year":"2015","journal-title":"J Antimicrob Chemother"},{"key":"2023060100351804100_dkad119-B20","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1097\/QAD.0000000000000267","article-title":"Comparison of ultra-deep versus sanger sequencing detection of minority mutations on the HIV-1 drug resistance interpretations after virological failure","volume":"28","author":"Mohamed","year":"2014","journal-title":"AIDS"},{"key":"2023060100351804100_dkad119-B21","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1128\/CMR.00015-16","article-title":"Total HIV-1 DNA, a marker of viral reservoir dynamics with clinical implications","volume":"29","author":"Avettand-F\u00e8no\u00ebl","year":"2016","journal-title":"Clin Microbiol Rev"},{"key":"2023060100351804100_dkad119-B22","doi-asserted-by":"crossref","first-page":"e0180191","DOI":"10.1371\/journal.pone.0180191","article-title":"Impact of early cART on HIV blood and semen compartments at the time of primary infection","volume":"12","author":"Ch\u00e9ret","year":"2017","journal-title":"PLoS One"},{"key":"2023060100351804100_dkad119-B23","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1111\/bcp.14586","article-title":"Pharmacological data of a successful 4-days-a-week regimen in HIV antiretroviral therapy (ANRS 162-4D trial)","volume":"87","author":"Abe","year":"2021","journal-title":"Br J Clin Pharmacol"},{"key":"2023060100351804100_dkad119-B24","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1097\/QAD.0000000000002169","article-title":"Effects on immune system and viral reservoir of a short-cycle antiretroviral therapy in virologically suppressed HIV-positive patients","volume":"33","author":"Guardo","year":"2019","journal-title":"AIDS"},{"key":"2023060100351804100_dkad119-B25","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1093\/cid\/ciz1243","article-title":"Efficacy and safety of switching to dolutegravir\/lamivudine fixed-dose 2-drug regimen vs continuing a tenofovir alafenamide-based 3- or 4-drug regimen for maintenance of virologic suppression in adults living with human immunodeficiency virus type 1: phase 3, randomized, noninferiority TANGO study","volume":"71","author":"van Wyk","year":"2020","journal-title":"Clin Infect Dis"},{"key":"2023060100351804100_dkad119-B26","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1073\/pnas.1318249111","article-title":"Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues","volume":"111","author":"Fletcher","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023060100351804100_dkad119-B27","doi-asserted-by":"crossref","first-page":"e328","DOI":"10.1016\/S2352-3018(17)30135-2","article-title":"The effect of treatment simplification on HIV reservoirs","volume":"4","author":"Darcis","year":"2017","journal-title":"Lancet HIV"},{"key":"2023060100351804100_dkad119-B28","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1093\/infdis\/jir518","article-title":"Factors associated with virological failure in HIV-1\u2013infected patients receiving darunavir\/ritonavir monotherapy","volume":"204","author":"Lambert-Niclot","year":"2011","journal-title":"J Infect Dis"},{"key":"2023060100351804100_dkad119-B29","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1093\/jac\/dkaa035","article-title":"Pharmacovirological analyses of blood and male genital compartment in patients receiving dolutegravir + lamivudine dual therapy as a switch strategy (ANRS 167 LAMIDOL trial)","volume":"75","author":"Charpentier","year":"2020","journal-title":"J Antimicrob Chemother"},{"key":"2023060100351804100_dkad119-B30","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1093\/jac\/dkaa058","article-title":"Evolution of cellular HIV DNA levels in virologically suppressed patients switching to dolutegravir\/lamivudine versus maintaining a triple regimen: a prospective, longitudinal, matched, controlled study","volume":"75","author":"Lombardi","year":"2020","journal-title":"J Antimicrob Chemother"},{"key":"2023060100351804100_dkad119-B31","doi-asserted-by":"crossref","first-page":"e0134430","DOI":"10.1371\/journal.pone.0134430","article-title":"Use of PCR signal and therapeutic drug monitoring in a switch cohort study to tenofovir\/emtricitabine\/rilpivirine: a W96 follow-up","volume":"10","author":"Charpentier","year":"2015","journal-title":"PLoS One"},{"key":"2023060100351804100_dkad119-B32","doi-asserted-by":"crossref","first-page":"ofz056","DOI":"10.1093\/ofid\/ofz056","article-title":"No significant changes to residual viremia after switch to dolutegravir and lamivudine in a randomized trial","volume":"6","author":"Li","year":"2019","journal-title":"Open Forum Infect Dis"},{"key":"2023060100351804100_dkad119-B33","first-page":"Abstract P311","article-title":"Comparison of viral replication below 50 copies\/mL for 2-drug (DTG\u200a+\u200aRPV) versus 3-drug current antiretroviral regimen (CAR) therapy in the SWORD-1 and SWORD-2 studies","volume":"21","author":"Underwood","year":"2018","journal-title":"J Int AIDS Soc"},{"key":"2023060100351804100_dkad119-B34","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1093\/cid\/ciu187","article-title":"HIV-1 DNA levels in peripheral blood mononuclear cells and cannabis use are associated with intermittent HIV shedding in semen of men who have sex with men on successful antiretroviral regimens","volume":"58","author":"Ghosn","year":"2014","journal-title":"Clin Infect Dis"},{"key":"2023060100351804100_dkad119-B35","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1093\/cid\/cit252","article-title":"Shedding of HIV and human herpesviruses in the semen of effectively treated HIV-1-infected men who have sex with men","volume":"57","author":"Gianella","year":"2013","journal-title":"Clin Infect Dis"},{"key":"2023060100351804100_dkad119-B36","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1097\/QAD.0b013e328352ae09","article-title":"Detection of HIV-1 RNA in seminal plasma samples from treated patients with undetectable HIV-1 RNA in blood plasma on a 2002-2011 survey","volume":"26","author":"Lambert-Niclot","year":"2012","journal-title":"AIDS"},{"key":"2023060100351804100_dkad119-B37","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1097\/QAD.0b013e32830abdc8","article-title":"Detection of HIV-1 RNA in seminal plasma samples from treated patients with undetectable HIV-1 RNA in blood plasma","volume":"22","author":"Marcelin","year":"2008","journal-title":"AIDS"},{"key":"2023060100351804100_dkad119-B38","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1097\/QAD.0b013e328353b11b","article-title":"Highly active antiretroviral therapy does not completely suppress HIV in semen of sexually active HIV-infected men who have sex with men","volume":"26","author":"Politch","year":"2012","journal-title":"AIDS"},{"key":"2023060100351804100_dkad119-B39","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1097\/QAD.0b013e3283303e04","article-title":"Persistent HIV RNA shedding in semen despite effective antiretroviral therapy","volume":"23","author":"Sheth","year":"2009","journal-title":"AIDS"},{"key":"2023060100351804100_dkad119-B40","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1097\/COH.0b013e32833a0b69","article-title":"Antiretroviral drug concentrations in the male and female genital tract: implications for the sexual transmission of HIV","volume":"5","author":"Taylor","year":"2010","journal-title":"Curr Opin HIV AIDS"},{"key":"2023060100351804100_dkad119-B41","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.3851\/IMP1919","article-title":"Pharmacokinetics of antiretroviral drugs in anatomical sanctuary sites: the male and female genital tract","volume":"16","author":"Else","year":"2011","journal-title":"Antivir Ther"},{"key":"2023060100351804100_dkad119-B42","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/mi.2012.1","article-title":"Mucosal correlates of isolated HIV semen shedding during effective antiretroviral therapy","volume":"5","author":"Sheth","year":"2012","journal-title":"Mucosal Immunol"},{"key":"2023060100351804100_dkad119-B43","first-page":"104","article-title":"HIV And sexually transmitted diseases: lethal synergy","volume":"12","author":"Cohen","year":"2004","journal-title":"Top HIV Med"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jac\/article-pdf\/78\/6\/1510\/50488884\/dkad119.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jac\/article-pdf\/78\/6\/1510\/50488884\/dkad119.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:39:10Z","timestamp":1685579950000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article\/78\/6\/1510\/7146011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,27]]},"references-count":43,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,4,27]]},"published-print":{"date-parts":[[2023,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dkad119","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,6]]},"published":{"date-parts":[[2023,4,27]]}}}