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Past and recent studies have indicated this may be achieved using doxycycline post-exposure prophylaxis (PEP) and this has sparked considerable interest in its use. However, many unanswered questions remain as to its long-term effects and particularly potentially negative impact on human microbiomes and antimicrobial resistance among STIs, other pathogens, and commensals. In this review, we discuss seven areas of concern pertaining to the widespread use of doxycycline PEP.<\/jats:p>","DOI":"10.1093\/jac\/dkad129","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T12:29:52Z","timestamp":1683030592000},"page":"1561-1568","source":"Crossref","is-referenced-by-count":72,"title":["Important considerations regarding the widespread use of doxycycline chemoprophylaxis against sexually transmitted infections"],"prefix":"10.1093","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9349-3080","authenticated-orcid":false,"given":"Fabian Yuh Shiong","family":"Kong","sequence":"first","affiliation":[{"name":"Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne , Melbourne , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2557-8998","authenticated-orcid":false,"given":"Chris","family":"Kenyon","sequence":"additional","affiliation":[{"name":"HIV\/STI Unit, Institute of Tropical Medicine , Antwerp , Belgium"},{"name":"Division of Infectious Diseases and HIV Medicine, University of Cape Town , Cape Town , South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Unemo","sequence":"additional","affiliation":[{"name":"WHO Collaborating Centre for Gonorrhoea and Other STIs, National Reference Laboratory for STIs, Department of Laboratory Medicine, \u00d6rebro University , \u00d6rebro , Sweden"},{"name":"Faculty of Population Health Sciences, Institute for Global Health, University College London , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,5,2]]},"reference":[{"key":"2023101607190698100_dkad129-B1","author":"WHO","year":"2021"},{"key":"2023101607190698100_dkad129-B2","doi-asserted-by":"crossref","first-page":"e528","DOI":"10.1016\/S2468-2667(21)00112-2","article-title":"HIV pre-exposure prophylaxis: scaling up for impact now and in the future","volume":"6","author":"Bavinton","year":"2021","journal-title":"Lancet Public Health"},{"key":"2023101607190698100_dkad129-B3","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/S1473-3099(17)30725-9","article-title":"Post-exposure prophylaxis with doxycycline to prevent sexually transmitted infections in men who have sex with men: an open-label randomised substudy of the ANRS IPERGAY trial","volume":"18","author":"Molina","year":"2018","journal-title":"Lancet Infect 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