{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:21:50Z","timestamp":1790965310155,"version":"4.1.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T00:00:00Z","timestamp":1692662400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the impact of carbapenem resistance on mortality in Klebsiella pneumoniae bloodstream infection (BSI) in the era of novel \u03b2-lactam\/\u03b2-lactamase inhibitor combinations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Retrospective study of patients with K. pneumoniae BSI between January and August 2020 in 16 centres (CARBANEW study within the MULTI-SITA project).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 426 patients were included: 107\/426 (25%) had carbapenem-resistant K. pneumoniae (CR-Kp) BSI and 319\/426 (75%) had carbapenem-susceptible K. pneumoniae (CS-Kp) BSI. Crude cumulative 30 day mortality was 33.8% and 20.7% in patients with, respectively, CR-Kp BSI and CS-Kp BSI (P\u200a=\u200a0.027). Carbapenemase production or carbapenemase-encoding genes were detected in 84\/98 tested CR-Kp isolates (85.7%), mainly KPC (78\/84; 92.9%). Ceftazidime\/avibactam was the most frequently used appropriate therapy for CR-Kp BSI (80\/107; 74.7%). In multivariable analyses, variables showing an unfavourable association with mortality after correction for multiple testing were age-adjusted Charlson comorbidity index (HR 1.20; 95% CI 1.10\u20131.31, P\u200a&amp;lt;\u200a0.001) and Pitt score (HR 1.33; 95% CI 1.15\u20131.55, P\u200a&amp;lt;\u200a0.001), but not carbapenem resistance (HR 1.28, 95% CI 0.74\u20132.22, P\u200a=\u200a0.410). In a propensity score-matched analysis, there was no difference in mortality between patients appropriately treated with ceftazidime\/avibactam for CR-Kp BSI and patients appropriately treated with other agents (mainly meropenem monotherapy or piperacillin\/tazobactam monotherapy) for CS-Kp BSI (HR 1.07; 95% CI 0.50\u20132.29, P\u200a=\u200a0.866).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest that the increased mortality in CR-Kp BSI compared with CS-Kp BSI is not (or no longer) dependent on the type of therapy in areas where ceftazidime\/avibactam-susceptible KPC-producing isolates are the most prevalent type of CR-Kp.<\/jats:p><\/jats:sec>","DOI":"10.1093\/jac\/dkad262","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T15:56:32Z","timestamp":1692719792000},"page":"2505-2514","source":"Crossref","is-referenced-by-count":45,"title":["Mortality in KPC-producing<i>Klebsiella pneumoniae<\/i>bloodstream infections: a changing landscape"],"prefix":"10.1093","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2385-1759","authenticated-orcid":false,"given":"Daniele Roberto","family":"Giacobbe","sequence":"first","affiliation":[{"name":"Department of Health Sciences (DISSAL), University of Genoa , Genoa , Italy"},{"name":"Clinica Malattie Infettive, IRCCS Ospedale Policlinico San Martino , Genoa , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1510-1819","authenticated-orcid":false,"given":"Cristina","family":"Marelli","sequence":"additional","affiliation":[{"name":"Clinica Malattie Infettive, IRCCS Ospedale Policlinico San Martino , Genoa , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta","family":"Cattardico","sequence":"additional","affiliation":[{"name":"Department of Health Sciences (DISSAL), University of Genoa , Genoa , Italy"},{"name":"Clinica Malattie Infettive, IRCCS Ospedale Policlinico San Martino , Genoa , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Fanelli","sequence":"additional","affiliation":[{"name":"Clinica Malattie Infettive, IRCCS Ospedale Policlinico San Martino , Genoa , Italy"},{"name":"Department of Medicine, Surgery and Pharmacy, Unit of Infectious Diseases, University of Sassari , Sassari , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Signori","sequence":"additional","affiliation":[{"name":"Section of Biostatistics, Department of Health Sciences (DISSAL), University of Genoa , Genoa , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Di Meco","sequence":"additional","affiliation":[{"name":"Clinica Malattie Infettive, IRCCS Ospedale Policlinico San Martino , Genoa , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5863-5805","authenticated-orcid":false,"given":"Vincenzo","family":"Di Pilato","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa , Genoa , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Mikulska","sequence":"additional","affiliation":[{"name":"Department of Health Sciences (DISSAL), University of Genoa , Genoa , Italy"},{"name":"Clinica Malattie Infettive, IRCCS Ospedale Policlinico San Martino , Genoa , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0263-0703","authenticated-orcid":false,"given":"Maria","family":"Mazzitelli","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Unit, Padova University Hospital , Padua , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Cattelan","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Unit, Padova University Hospital , Padua , Italy"},{"name":"Department of Molecular Medicine, University of Padua , Padua , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Pallotto","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Clinic of Infectious Diseases, \u2018Santa Maria della Misericordia\u2019 Hospital, University of Perugia , Perugia , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Francisci","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Clinic of Infectious Diseases, \u2018Santa Maria della Misericordia\u2019 Hospital, University of Perugia , Perugia , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Calabresi","sequence":"additional","affiliation":[{"name":"SOC Malattie Infettive, ASO \u2018SS Antonio e Biagio e C. Arrigo\u2019 , Alessandria , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0383-9579","authenticated-orcid":false,"given":"Andrea","family":"Lombardi","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Foundation IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico , Milan , Italy"},{"name":"Department of Pathophysiology and Transplantation, University of Milan , Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Gori","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Transplantation, University of Milan , Milan , Italy"},{"name":"Azienda Socio Sanitaria Territoriale (ASST) Fatebenefratelli-Sacco, Ospedale Luigi Sacco\u2014Polo Universitario , Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Del Bono","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Azienda Ospedaliera S. Croce e Carle , Cuneo , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Aldieri","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Azienda Ospedaliera S. Croce e Carle , Cuneo , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela Raffaella","family":"Losito","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Raffaelli","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Cortegiani","sequence":"additional","affiliation":[{"name":"Department of Surgical, Oncological and Oral Science, University of Palermo , Palermo , Italy"},{"name":"Department of Anesthesia Analgesia Intensive Care and Emergency, Policlinico Paolo Giaccone , Palermo , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Milazzo","sequence":"additional","affiliation":[{"name":"Department of Surgical, Oncological and Oral Science, University of Palermo , Palermo , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Del Puente","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Galliera Hospital , Genoa , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Pontali","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Galliera Hospital , Genoa , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8338-0130","authenticated-orcid":false,"given":"Francesco Giuseppe","family":"De Rosa","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Infectious Diseases, University of Turin , Turin , Italy"},{"name":"Unit of Infectious Diseases, Cardinal Massaia , Asti , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2949-4297","authenticated-orcid":false,"given":"Silvia","family":"Corcione","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Infectious Diseases, University of Turin , Turin , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8612-5581","authenticated-orcid":false,"given":"Alessandra","family":"Mularoni","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, ISMETT-IRCCS Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione , Palermo , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Russelli","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, ISMETT-IRCCS Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione , Palermo , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5646-2034","authenticated-orcid":false,"given":"Mauro","family":"Giacomini","sequence":"additional","affiliation":[{"name":"Department of Informatics, Bioengineering, Robotics and System Engineering (DIBRIS), University of Genoa , Genoa , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Badalucco Ciotta","sequence":"additional","affiliation":[{"name":"Clinic of Infectious Diseases, Vita-Salute University, San Raffaele Scientific Institute , Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Oltolini","sequence":"additional","affiliation":[{"name":"Clinic of Infectious Diseases, Vita-Salute University, San Raffaele Scientific Institute , Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco Saverio","family":"Serino","sequence":"additional","affiliation":[{"name":"Azienda ULSS4 Veneto Orientale, UOS Malattie Infettive, UOC Medicina Generale, Ospedale di Portogruaro , Portogruaro , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Momesso","sequence":"additional","affiliation":[{"name":"Azienda ULSS4 Veneto Orientale, UOC Anestesia e Rianimazione, Ospedale di San Don\u00e0 di Piave , San Don\u00e0 di Piave , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Spinicci","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Florence , Florence , Italy"},{"name":"Infectious and Tropical Diseases Unit, Careggi University Hospital , Florence , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4829-9796","authenticated-orcid":false,"given":"Lucia","family":"Graziani","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Florence , Florence , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Torti","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University \u2018Magna Graecia\u2019 , Catanzaro , Italy"},{"name":"Unit of Infectious and Tropical Diseases, \u2018Mater Domini\u2019 Teaching Hospital , Catanzaro , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico Maria","family":"Trecarichi","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University \u2018Magna Graecia\u2019 , Catanzaro , Italy"},{"name":"Unit of Infectious and Tropical Diseases, \u2018Mater Domini\u2019 Teaching Hospital , Catanzaro , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5081-8669","authenticated-orcid":false,"given":"Marco","family":"Merli","sequence":"additional","affiliation":[{"name":"Infectious Diseases Clinic, ASST Grande Ospedale Metropolitano Niguarda , Milano , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"D\u2019Amico","sequence":"additional","affiliation":[{"name":"Infectious Diseases Clinic, ASST Grande Ospedale Metropolitano Niguarda , Milano , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Marchese","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa , Genoa , Italy"},{"name":"UO Microbiologia, IRCCS Ospedale Policlinico San Martino , Genoa , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Vena","sequence":"additional","affiliation":[{"name":"Department of Health Sciences (DISSAL), University of Genoa , Genoa , Italy"},{"name":"Clinica Malattie Infettive, IRCCS Ospedale Policlinico San Martino , Genoa , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Bassetti","sequence":"additional","affiliation":[{"name":"Department of Health Sciences (DISSAL), University of Genoa , Genoa , Italy"},{"name":"Clinica Malattie Infettive, IRCCS Ospedale Policlinico San Martino , Genoa , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,8,22]]},"reference":[{"key":"2023100302084995100_dkad262-B1","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1111\/j.1469-0691.2011.03514.x","article-title":"Predictors of mortality in patients with bloodstream infections caused by KPC-producing Klebsiella pneumoniae and impact of appropriate antimicrobial treatment","volume":"17","author":"Zarkotou","year":"2011","journal-title":"Clin Microbiol Infect"},{"key":"2023100302084995100_dkad262-B2","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1093\/jac\/dkv086","article-title":"Infections caused by KPC-producing Klebsiella pneumoniae: differences in therapy and mortality in a multicentre study","volume":"70","author":"Tumbarello","year":"2015","journal-title":"J Antimicrob Chemother"},{"key":"2023100302084995100_dkad262-B3","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s40121-021-00408-8","article-title":"The impact of carbapenem resistance on mortality in patients with Klebsiella pneumoniae bloodstream infection: an individual patient data meta-analysis of 1952 patients","volume":"10","author":"Maraolo","year":"2021","journal-title":"Infect Dis Ther"},{"key":"2023100302084995100_dkad262-B4","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1080\/14787210.2021.1935237","article-title":"Carbapenemase producing Klebsiella pneumoniae: implication on future therapeutic strategies","volume":"20","author":"Karaiskos","year":"2022","journal-title":"Expert Rev Anti Infect Ther"},{"key":"2023100302084995100_dkad262-B5","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S1473-3099(17)30228-1","article-title":"Effect of appropriate combination therapy on mortality of patients with bloodstream infections due to carbapenemase-producing Enterobacteriaceae (INCREMENT): a retrospective cohort study","volume":"17","author":"Gutierrez-Gutierrez","year":"2017","journal-title":"Lancet Infect Dis"},{"key":"2023100302084995100_dkad262-B6","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1128\/AAC.02166-13","article-title":"Carbapenemase-producing Klebsiella pneumoniae bloodstream infections: lowering mortality by antibiotic combination schemes and the role of carbapenems","volume":"58","author":"Daikos","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"2023100302084995100_dkad262-B7","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.cmi.2017.08.030","article-title":"Management of KPC-producing Klebsiella pneumoniae infections","volume":"24","author":"Bassetti","year":"2018","journal-title":"Clin Microbiol Infect"},{"key":"2023100302084995100_dkad262-B8","doi-asserted-by":"crossref","first-page":"ofy150","DOI":"10.1093\/ofid\/ofy150","article-title":"Association between carbapenem resistance and mortality among adult, hospitalized patients with serious infections due to Enterobacteriaceae: results of a systematic literature review and meta-analysis","volume":"5","author":"Martin","year":"2018","journal-title":"Open Forum Infect Dis"},{"key":"2023100302084995100_dkad262-B9","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s13756-020-00728-3","article-title":"Five-year change of prevalence and risk factors for infection and mortality of carbapenem-resistant Klebsiella pneumoniae bloodstream infection in a tertiary hospital in north China","volume":"9","author":"Li","year":"2020","journal-title":"Antimicrob Resist Infect Control"},{"key":"2023100302084995100_dkad262-B10","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1017\/ice.2017.197","article-title":"Carbapenem resistance, initial antibiotic therapy, and mortality in Klebsiella pneumoniae bacteremia: a systematic review and meta-analysis","volume":"38","author":"Kohler","year":"2017","journal-title":"Infect Control Hosp Epidemiol"},{"key":"2023100302084995100_dkad262-B11","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/phar.2209","article-title":"International consensus guidelines for the optimal use of the polymyxins: endorsed by the American College of Clinical Pharmacy (ACCP), European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Infectious Diseases Society of America (IDSA), International Society for Anti-infective Pharmacology (ISAP), Society of Critical Care Medicine (SCCM), and Society of Infectious Diseases Pharmacists (SIDP)","volume":"39","author":"Tsuji","year":"2019","journal-title":"Pharmacotherapy"},{"key":"2023100302084995100_dkad262-B12","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/07853890.2022.2152484","article-title":"Treatment and diagnosis of severe KPC-producing Klebsiella pneumoniae infections: a perspective on what has changed over last decades","volume":"55","author":"Giacobbe","year":"2023","journal-title":"Ann Med"},{"key":"2023100302084995100_dkad262-B13","doi-asserted-by":"crossref","first-page":"499","DOI":"10.2307\/2531021","article-title":"Sample-size formula for the proportional-hazards regression model","volume":"39","author":"Schoenfeld","year":"1983","journal-title":"Biometrics"},{"key":"2023100302084995100_dkad262-B14","author":"Yuan","year":"2010"},{"key":"2023100302084995100_dkad262-B15","doi-asserted-by":"crossref","first-page":"3424","DOI":"10.1177\/0962280220921889","article-title":"A tutorial on frailty models","volume":"29","author":"Balan","year":"2020","journal-title":"Stat Methods Med Res"},{"key":"2023100302084995100_dkad262-B16","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J R Stat Soc B (Methodological)"},{"key":"2023100302084995100_dkad262-B17","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/biomet\/70.1.41","article-title":"The central role of the propensity score in observational studies for causal effects","volume":"70","author":"Rosenbaum","year":"1983","journal-title":"Biometrika"},{"key":"2023100302084995100_dkad262-B18","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1080\/00273171.2011.568786","article-title":"An introduction to propensity score methods for reducing the effects of confounding in observational studies","volume":"46","author":"Austin","year":"2011","journal-title":"Multivariate Behav Res"},{"key":"2023100302084995100_dkad262-B19","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1093\/cid\/ciad100","article-title":"Mortality attributable to bloodstream infections caused by different carbapenem-resistant gram negative bacilli: results from a nationwide study in Italy (ALARICO network)","volume":"76","author":"Falcone","year":"2023","journal-title":"Clin Infect Dis"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jac\/article-pdf\/78\/10\/2505\/51743392\/dkad262.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jac\/article-pdf\/78\/10\/2505\/51743392\/dkad262.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T20:57:57Z","timestamp":1729889877000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article\/78\/10\/2505\/7247462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,22]]},"references-count":19,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,8,22]]},"published-print":{"date-parts":[[2023,10,3]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dkad262","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,10]]},"published":{"date-parts":[[2023,8,22]]}}}