{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:12:27Z","timestamp":1788261147998,"version":"build-2803163510"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Broad Agency Announcement"},{"DOI":"10.13039\/100006190","name":"Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006190","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Department of Microbiology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Increasing incidence of invasive group A Streptococcus (iGAS) disease has been reported in Europe and the USA over the past several years. Coupled with this are observations of higher rates of resistance to erythromycin and clindamycin.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To characterize iGAS and pharyngitis isolates from West Virginia (WV), a US state outside of the national Active Bacteria Core surveillance purview, where risk factors associated with iGAS infections are prevalent.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Seventy-seven invasive group A Streptococcus isolates were collected from 67 unique patients at the J.W. Ruby Memorial Hospital Clinical Microbiology Laboratory in WV from 2021 to 2023. Invasive isolates and 20 unique pharyngitis isolates were tested for clindamycin and erythromycin susceptibility in the clinical laboratory. Patient demographic and clinical information was retrieved from patient electronic health records. Isolates were further characterized based on emm subtype and detection of MLSB resistance determinants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Twenty-six (39%) isolates were of a single emm92 type. All emm92 isolates were uniformly erythromycin\/clindamycin resistant with inducible or constitutive MLSB resistance imparted by the plasmid-borne erm(T) gene. The majority of emm92 infections were associated with adult patients who reported IV drug use, whereas no pharyngitis infections were caused by an emm92 strain. Overall, 51 (76%) of the 67 iGAS isolates were determined to carry MLSB resistance.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Isolates of emm92 type (clonal subtype emm92.0) were associated with iGAS infections in adult IV drug users, but not with paediatric pharyngitis, and were uniformly resistant to erythromycin and clindamycin.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkad268","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T08:46:20Z","timestamp":1693212380000},"page":"2554-2558","source":"Crossref","is-referenced-by-count":10,"title":["Prevalence of erythromycin-resistant <i>emm92<\/i>-type invasive group A streptococcal infections among injection drug users in West Virginia, United States, 2021\u201323"],"prefix":"10.1093","volume":"78","author":[{"given":"Lillie M","family":"Powell","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology, and Cell Biology, West Virginia University School of Medicine , 2095 Health Sciences North, Morgantown, WV, 26506 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Jeon","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Cell Biology, West Virginia University School of Medicine , 2095 Health Sciences North, Morgantown, WV, 26506 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breanna L","family":"Haught","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Cell Biology, West Virginia University School of Medicine , 2095 Health Sciences North, Morgantown, WV, 26506 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Demkowicz","sequence":"additional","affiliation":[{"name":"Department of Pathology, West Virginia 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