{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:29:19Z","timestamp":1789752559580,"version":"4.0.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:00:00Z","timestamp":1695686400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Polypharmacy can lead to drug\u2013drug interactions (DDIs), especially with ART. The burden of co-medications, including over-the-counter (OTC) drugs and self-medications, could be underestimated. We aimed to investigate the proportion of people living with HIV (PLHIV) with declared and undeclared co-medications, as well as their potential burden.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a national, multicentre, 1 week cross-sectional study between 10 December and 16 December 2019 in 23 French hospitals amongst consecutive adult PLHIV presenting for a routine outpatient visit. A standardized questionnaire filled in by the physicians assessed all medications and other active chemical substances taken by the PLHIV.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Overall we enrolled 496 participants from 23 centres. Median age was 50.6 years; ART regimens included an integrase inhibitor in 61% (n\u200a=\u200a302), an NNRTI in 34% (n\u200a=\u200a169) and a PI in 14% (n\u200a=\u200a70) of the cases. Co-medications involved 392 (79%) PLHIV, among which 85 (17%) received polypharmacy (\u22655 medications). Previously unknown co-medications or other active substances were found for 32% (n\u200a=\u200a159) of the participants. Corticosteroids (9%, n\u200a=\u200a46) and proton pump inhibitors (10%, n\u200a=\u200a50) were frequently administered. These co-medications did not differ according to age range. Illegal drug use was declared by 11% (n\u200a=\u200a54) and OTC drugs by 23% (n\u200a=\u200a113) of PLHIV. Potential DDIs were discovered for 11% (n\u200a=\u200a53), leading to treatment modifications in 47% (25\/53) of cases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Potential DDIs that lead to therapeutic modifications remain significant whatever the age of PLHIV. More devoted time to identify co-medications and OTC treatment is needed in all PLHIV.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkad292","type":"journal-article","created":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T21:34:13Z","timestamp":1695850453000},"page":"2731-2734","source":"Crossref","is-referenced-by-count":8,"title":["Are unknown co-medications, over-the-counter and off-label drug use still problems among people living with HIV? Results from a transversal survey in 23 centres in France"],"prefix":"10.1093","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6723-8089","authenticated-orcid":false,"given":"Macha","family":"Tetart","sequence":"first","affiliation":[{"name":"Service Universitaire des Maladies Infectieuses et du Voyageur , Tourcoing, Hauts de France , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila","family":"Passecountrin","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses et Tropicales, La Piti\u00e9 Salp\u00eatri\u00e8re, APHP , Paris, Ile de France , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana\u00efs","family":"Lesourd","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses et Tropicales, CHU Rouen , Rouen, Seine Maritime , 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