{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T07:20:08Z","timestamp":1785223208127,"version":"3.55.0"},"reference-count":78,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T00:00:00Z","timestamp":1698969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["K23 DK095707"],"award-info":[{"award-number":["K23 DK095707"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Robert J. Havey, MD Institute for Global Health"},{"DOI":"10.13039\/100007059","name":"Northwestern University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007059","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Richard and Susan Kiphart Northwestern Global Health Research Fund"},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>An enhanced understanding of renal outcomes in persons with chronic HBV, HIV, and HBV\/HIV coinfection is needed to mitigate chronic kidney disease in regions where HBV and HIV are endemic.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To investigate changes in estimated glomerular filtration rate (eGFR) in adults with HBV, HIV or HBV\/HIV enrolled in a 3 year prospective cohort study of liver outcomes in Dar es Salaam, Tanzania and initiated on antiviral therapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We compared eGFR between and within groups over time using mixed-effects models.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Four hundred and ninety-nine participants were included in the analysis (HBV: 164; HIV: 271; HBV\/HIV: 64). Mean baseline eGFRs were 106.88, 106.03 and 107.18 mL\/min\/1.73 m2, respectively. From baseline to Year 3, mean eGFR declined by 4.3 mL\/min\/1.73 m2 (95% CI \u22129.3 to 0.7) and 3.7 (\u22127.8 to 0.5) in participants with HBV and HIV, respectively, and increased by 5.1 (\u22124.7 to 14.9) in those with HBV\/HIV. In multivariable models, participants with HBV had lower eGFRs compared with those with HIV or HBV\/HIV and, after adjusting for HBV DNA level and hepatitis B e antigen (HBeAg) status, significantly lower eGFRs than those with HBV\/HIV at all follow-up visits.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In this Tanzanian cohort, coinfection with HBV\/HIV did not appear to exacerbate renal dysfunction compared with those with either infection alone. Although overall changes in eGFR were small, persons with HBV experienced lower eGFRs throughout follow-up despite their younger age and similar baseline values. Longer-term studies are needed to evaluate continuing changes in eGFR and contributions from infection duration and other comorbidities.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkad341","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T23:20:53Z","timestamp":1699399253000},"page":"36-45","source":"Crossref","is-referenced-by-count":2,"title":["Renal outcomes in adults with HBV, HIV and HBV\/HIV coinfection after 3 years of antiviral therapy in urban Tanzania"],"prefix":"10.1093","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5679-6277","authenticated-orcid":false,"given":"En-Ling","family":"Wu","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine , Chicago, IL ,","place":["USA"]},{"name":"Section of Infectious Diseases and Global Health, Department of Medicine, University of Chicago , Chicago, IL ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Christian","sequence":"additional","affiliation":[{"name":"Management and Development for Health , Dar es Salaam ,","place":["Tanzania"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2533-0818","authenticated-orcid":false,"given":"Adovich S","family":"Rivera","sequence":"additional","affiliation":[{"name":"Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine , Chicago, IL ,","place":["USA"]},{"name":"Division of Epidemiologic Research, Department of Research and Evaluation , Kaiser Permanente Southern California, Pasadena, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuel","family":"Fabian","sequence":"additional","affiliation":[{"name":"Management and Development for Health , Dar es Salaam ,","place":["Tanzania"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Macha","sequence":"additional","affiliation":[{"name":"Management and Development for Health , Dar es Salaam ,","place":["Tanzania"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Aris","sequence":"additional","affiliation":[{"name":"Management and Development for Health , Dar es Salaam ,","place":["Tanzania"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shida","family":"Mpangala","sequence":"additional","affiliation":[{"name":"Management and Development for Health , Dar es Salaam ,","place":["Tanzania"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nzovu","family":"Ulenga","sequence":"additional","affiliation":[{"name":"Management and Development for Health , Dar es Salaam ,","place":["Tanzania"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinand","family":"Mugusi","sequence":"additional","affiliation":[{"name":"Management and Development for Health , Dar es Salaam ,","place":["Tanzania"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3936-2052","authenticated-orcid":false,"given":"Robert L","family":"Murphy","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine , Chicago, IL ,","place":["USA"]},{"name":"Havey Institute for Global Health, Northwestern University Feinberg School of Medicine , Chicago, IL ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia A","family":"Hawkins","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine , Chicago, IL ,","place":["USA"]},{"name":"Havey Institute for Global Health, Northwestern University Feinberg School of Medicine , Chicago, IL ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,11,3]]},"reference":[{"key":"2024102107485548300_dkad341-B1","year":"2022"},{"key":"2024102107485548300_dkad341-B2","doi-asserted-by":"crossref","first-page":"e1024","DOI":"10.1016\/j.ijid.2010.06.013","article-title":"Hepatitis B\/C and HIV in sub-Saharan Africa: an association between highly prevalent infectious diseases. 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