{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:39:39Z","timestamp":1772138379327,"version":"3.50.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T00:00:00Z","timestamp":1704240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the impact of piperacillin\/tazobactam MICs on in-hospital 30 day mortality in patients with third-generation cephalosporin-resistant Escherichia coli bloodstream infection treated with piperacillin\/tazobactam, compared with those treated with carbapenems.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A multicentre retrospective cohort study was conducted in three large academic hospitals in Italy between 2018 and 2022. The study population comprised patients with monomicrobial third-generation cephalosporin-resistant E. coli bloodstream infection, who received either piperacillin\/tazobactam or carbapenem therapy within 48 h of blood culture collection. The primary outcome was in-hospital 30 day all-cause mortality. A propensity score was used to estimate the likelihood of receiving empirical piperacillin\/tazobactam treatment. Cox regression models were performed to ascertain risk factors independently associated with in-hospital 30 day mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 412 consecutive patients included in the study, 51% received empirical therapy with piperacillin\/tazobactam, while 49% received carbapenem therapy. In the propensity-adjusted multiple Cox model, the Pitt bacteraemia score [HR 1.38 (95% CI, 0.85\u20132.16)] and piperacillin\/tazobactam MICs of 8 mg\/L [HR 2.35 (95% CI, 1.35\u20133.95)] and \u226516 mg\/L [HR 3.69 (95% CI, 1.86\u20136.91)] were significantly associated with increased in-hospital 30 day mortality, while the empirical use of piperacillin\/tazobactam was not found to predict in-hospital 30 day mortality [HR 1.38 (95% CI, 0.85\u20132.16)].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Piperacillin\/tazobactam use might not be associated with increased mortality in treating third-generation cephalosporin-resistant E. coli bloodstream infections when the MIC is &amp;lt;8 mg\/L.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jac\/dkad404","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T11:37:38Z","timestamp":1703158658000},"page":"453-461","source":"Crossref","is-referenced-by-count":5,"title":["Association of piperacillin\/tazobactam MIC and mortality in a cohort of ceftriaxone-resistant\n                    <i>Escherichia coli<\/i>\n                    bloodstream infections treated with piperacillin\/tazobactam and carbapenems: a multicentric propensity score-weighted observational cohort study"],"prefix":"10.1093","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6573-9584","authenticated-orcid":false,"given":"Emanuele","family":"Rando","sequence":"first","affiliation":[{"name":"Dipartimento di Sicurezza e Bioetica\u2014Sezione di Malattie Infettive, Universit\u00e0 Cattolica del Sacro Cuore , Rome , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2273-0683","authenticated-orcid":false,"given":"Federica","family":"Salvati","sequence":"additional","affiliation":[{"name":"Dipartimento di Sicurezza e Bioetica\u2014Sezione di Malattie Infettive, Universit\u00e0 Cattolica del Sacro Cuore , Rome , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavio","family":"Sangiorgi","sequence":"additional","affiliation":[{"name":"Dipartimento di Sicurezza e Bioetica\u2014Sezione di Malattie Infettive, Universit\u00e0 Cattolica del Sacro Cuore , Rome , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Catania","sequence":"additional","affiliation":[{"name":"Dipartimento di Sicurezza e Bioetica\u2014Sezione di Malattie Infettive, Universit\u00e0 Cattolica del Sacro Cuore , Rome , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Leone","sequence":"additional","affiliation":[{"name":"Dipartimento di Sicurezza e Bioetica\u2014Sezione di Malattie Infettive, Universit\u00e0 Cattolica del Sacro Cuore , Rome , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0832-7975","authenticated-orcid":false,"given":"Alessandra","family":"Oliva","sequence":"additional","affiliation":[{"name":"Department of Public Health and Infectious Diseases, Sapienza University of Rome , Rome , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Di Gennaro","sequence":"additional","affiliation":[{"name":"Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), Unit of Infectious Diseases, University of Bari \u2018A. Moro\u2019, Polyclinic Hospital , Bari , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Fiori","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A Gemelli IRCCS , Rome , Italy"},{"name":"Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Universit\u00e0 Cattolica del Sacro Cuore , Rome , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Cancelli","sequence":"additional","affiliation":[{"name":"Department of Public Health and Infectious Diseases, Sapienza University of Rome , Rome , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Figliomeni","sequence":"additional","affiliation":[{"name":"Department of Public Health and Infectious Diseases, Sapienza University of Rome , Rome , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Bobbio","sequence":"additional","affiliation":[{"name":"Department of Public Health and Infectious Diseases, Sapienza University of Rome , Rome , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Sacco","sequence":"additional","affiliation":[{"name":"Department of Public Health and Infectious Diseases, Sapienza University of Rome , Rome , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide Fiore","family":"Bavaro","sequence":"additional","affiliation":[{"name":"Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), Unit of Infectious Diseases, University of Bari \u2018A. Moro\u2019, Polyclinic Hospital , Bari , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Diella","sequence":"additional","affiliation":[{"name":"Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), Unit of Infectious Diseases, University of Bari \u2018A. Moro\u2019, Polyclinic Hospital , Bari , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Belati","sequence":"additional","affiliation":[{"name":"Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), Unit of Infectious Diseases, University of Bari \u2018A. Moro\u2019, Polyclinic Hospital , Bari , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annalisa","family":"Saracino","sequence":"additional","affiliation":[{"name":"Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), Unit of Infectious Diseases, University of Bari \u2018A. 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