{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:49:01Z","timestamp":1792194541727,"version":"4.4.0"},"reference-count":192,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T00:00:00Z","timestamp":1707436800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Strategic Programme Excellence Initiative at Jagiellonian University","award":["U1C\/W42\/NO\/28.15"],"award-info":[{"award-number":["U1C\/W42\/NO\/28.15"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Managing drug\u2013food interactions may help to achieve the optimal action and safety profile of \u03b2-lactam antibiotics.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a systematic review with meta-analyses in adherence to PRISMA guidelines for 32 \u03b2-lactams. We included 166 studies assessing the impact of food, beverages, antacids or mineral supplements on the pharmacokinetic (PK) parameters or PK\/pharmacodynamic (PK\/PD) indices.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Eighteen of 25 \u03b2-lactams for which data on food impact were available had clinically important interactions. We observed the highest negative influence of food (AUC or Cmax decreased by &amp;gt;40%) for ampicillin, cefaclor (immediate-release formulations), cefroxadine, cefradine, cloxacillin, oxacillin, penicillin V (liquid formulations and tablets) and sultamicillin, whereas the highest positive influence (AUC or Cmax increased by &amp;gt;45%) for cefditoren pivoxil, cefuroxime and tebipenem pivoxil (extended-release tablets). Significantly lower bioavailability in the presence of antacids or mineral supplements occurred for 4 of 13 analysed \u03b2-lactams, with the highest negative impact for cefdinir (with iron salts) and moderate for cefpodoxime proxetil (with antacids). Data on beverage impact were limited to 11 antibiotics. With milk, the extent of absorption was decreased by &amp;gt;40% for cefalexin, cefradine, penicillin G and penicillin V, whereas it was moderately increased for cefuroxime. No significant interaction occurred with cranberry juice for two tested drugs (amoxicillin and cefaclor).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Factors such as physicochemical features of antibiotics, drug formulation, type of intervention, and patient\u2019s health state may influence interactions. Due to the poor actuality and diverse methodology of included studies and unproportionate data availability for individual drugs, we judged the quality of evidence as low.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkae028","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T14:24:24Z","timestamp":1707488664000},"page":"722-757","source":"Crossref","is-referenced-by-count":10,"title":["Do dietary interventions exert clinically important effects on the bioavailability of \u03b2-lactam antibiotics? A systematic review with meta-analyses"],"prefix":"10.1093","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4926-6120","authenticated-orcid":false,"given":"Agnieszka","family":"Wiesner","sequence":"first","affiliation":[{"name":"Doctoral School of Medical and Health Sciences, Jagiellonian University Medical College , Krakow ,","place":["Poland"]},{"name":"Department of Food Chemistry and Nutrition, Faculty of Pharmacy, Jagiellonian University Medical College , Krakow ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5101-036X","authenticated-orcid":false,"given":"Pawe\u0142","family":"Zagrodzki","sequence":"additional","affiliation":[{"name":"Department of Food Chemistry and Nutrition, Faculty of Pharmacy, Jagiellonian University Medical College , Krakow ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4821-4492","authenticated-orcid":false,"given":"Pawe\u0142","family":"Pa\u015bko","sequence":"additional","affiliation":[{"name":"Department of Food Chemistry and Nutrition, Faculty of Pharmacy, Jagiellonian University Medical College , Krakow ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,2,9]]},"reference":[{"key":"2024110112225978800_dkae028-B1","volume-title":"StatPearls","author":"Pandey","year":"2022"},{"key":"2024110112225978800_dkae028-B2","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1039\/D1MD00200G","article-title":"\u03b2-Lactam antibiotic targets and resistance mechanisms: from covalent inhibitors to substrates","volume":"12","author":"Mora-Ochomogo","year":"2021","journal-title":"RSC Med Chem"},{"key":"2024110112225978800_dkae028-B3","doi-asserted-by":"crossref","first-page":"953","DOI":"10.3389\/fmicb.2019.00953","article-title":"Distinct roles of outer membrane porins in antibiotic resistance and membrane integrity in Escherichia coli","volume":"10","author":"Choi","year":"2019","journal-title":"Front Microbiol"},{"key":"2024110112225978800_dkae028-B4","author":"ECDC"},{"key":"2024110112225978800_dkae028-B5","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1186\/s13054-018-2155-1","article-title":"Pharmacokinetics\u2013pharmacodynamics issues relevant for the clinical use of beta-lactam antibiotics in critically ill patients","volume":"22","author":"Veiga","year":"2018","journal-title":"Crit Care"},{"key":"2024110112225978800_dkae028-B6","doi-asserted-by":"crossref","DOI":"10.1007\/978-0-387-75613-4","volume-title":"Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics","author":"Vinks","year":"2014"},{"key":"2024110112225978800_dkae028-B7","first-page":"714","volume-title":"Antybiotykoterapia Praktyczna [Antibiotic therapy in Practice]","author":"Dzier\u017canowska","year":"2018"},{"key":"2024110112225978800_dkae028-B8","volume-title":"Interakcje lek\u00f3w z po\u017cywieniem [Interactions between drugs and food]","author":"Zachwieja","year":"2016"},{"key":"2024110112225978800_dkae028-B9","doi-asserted-by":"crossref","first-page":"235","DOI":"10.21615\/cesmedicina.32.3.5","article-title":"Clinical relevance of drug interactions with antibiotics related to changes in the absorption: structured review","volume":"32","author":"Pino-Mar\u00edn","year":"2018","journal-title":"CES Medicina"},{"key":"2024110112225978800_dkae028-B10","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1128\/AAC.33.11.1901","article-title":"Influence of ranitidine, pirenzepine, and aluminum magnesium hydroxide on the bioavailability of various antibiotics, including amoxicillin, cephalexin, doxycycline, and amoxicillin-clavulanic acid","volume":"33","author":"Deppermann","year":"1989","journal-title":"Antimicrob Agents Chemother"},{"key":"2024110112225978800_dkae028-B11","doi-asserted-by":"crossref","first-page":"e02167-19","DOI":"10.1128\/AAC.02167-19","article-title":"Fact versus fiction: a review of the evidence behind alcohol and antibiotic interactions","volume":"64","author":"Mergenhagen","year":"2020","journal-title":"Antimicrob Agents Chemother"},{"key":"2024110112225978800_dkae028-B12","doi-asserted-by":"crossref","first-page":"l4898","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"key":"2024110112225978800_dkae028-B13","author":"Higgins"},{"key":"2024110112225978800_dkae028-B14","author":"NIH"},{"key":"2024110112225978800_dkae028-B15","doi-asserted-by":"crossref","first-page":"6072","DOI":"10.1002\/sim.3427","article-title":"Meta-analysis of skewed data: combining results reported on log-transformed or raw scales","volume":"27","author":"Higgins","year":"2008","journal-title":"Stat Med"},{"key":"2024110112225978800_dkae028-B16","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/1471-2288-14-135","article-title":"Estimating the sample mean and standard deviation from the sample size, median, range and\/or interquartile range","volume":"14","author":"Wan","year":"2014","journal-title":"BMC Med Res Methodol"},{"key":"2024110112225978800_dkae028-B17","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 6.3","author":"Deeks","year":"2022"},{"key":"2024110112225978800_dkae028-B18","first-page":"73","article-title":"Oral pharmacokinetics of cefuroxime axetil in diabetic patients with autonomic neuropathy","volume":"18","author":"Bouter","year":"1993","journal-title":"Tijdschrift voor Therapie Geneesmiddel en Onderzoek"},{"key":"2024110112225978800_dkae028-B19","first-page":"103","article-title":"Effect of food on the bioavailability of cefpodoxime proxetil in healthy Chinese subjects","volume":"48","author":"Chen","year":"1996","journal-title":"Chin Pharm J"},{"key":"2024110112225978800_dkae028-B20","first-page":"263","article-title":"Oral bioavailability of cefadroxil, a new semisynthetic cephalosporin","volume":"1","author":"Henness","year":"1978","journal-title":"Clin Ther"},{"key":"2024110112225978800_dkae028-B21","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1097\/00000441-196506000-00002","article-title":"Cloxacillin: activity in vitro, and absorption and urinary excretion in normal young men","volume":"249","author":"Kislak","year":"1965","journal-title":"Am J Med Sci"},{"key":"2024110112225978800_dkae028-B22","author":"Health Products Regulatory Authority"},{"key":"2024110112225978800_dkae028-B23","author":"FDA"},{"key":"2024110112225978800_dkae028-B24","author":"FDA"},{"key":"2024110112225978800_dkae028-B25","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/0306-3623(94)90355-7","article-title":"Cephalexin concentrations in radicular granuloma following a single oral administration of 250 or 500\u2005mg cephalexin","volume":"25","author":"Akimoto","year":"1994","journal-title":"Gen Pharmacol"},{"key":"2024110112225978800_dkae028-B26","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0378-5173(80)90113-1","article-title":"The effect of Sudanese diet on the bioavailability of ampicillin","volume":"8","author":"Ali","year":"1980","journal-title":"Int J Pharm"},{"key":"2024110112225978800_dkae028-B27","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0378-5173(81)90043-0","article-title":"The effect of Sudanese food and chloroquine on the bioavailability of ampicillin from bacampicillin tablets","volume":"9","author":"Ali","year":"1981","journal-title":"Int J Pharm"},{"key":"2024110112225978800_dkae028-B28","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1128\/AAC.34.6.1210","article-title":"Comparison of the effects of food on the pharmacokinetics of cefprozil and cefaclor","volume":"34","author":"Barbhaiya","year":"1990","journal-title":"Antimicrob Agents Chemother"},{"key":"2024110112225978800_dkae028-B29","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0732-8893(91)90096-X","article-title":"The pharmacokinetics of ceftibuten in humans","volume":"14","author":"Barr","year":"1991","journal-title":"Diagn Microbiol Infect Dis"},{"key":"2024110112225978800_dkae028-B30","doi-asserted-by":"crossref","first-page":"S93","DOI":"10.1097\/00006454-199507001-00005","article-title":"Pharmacokinetics of ceftibuten in children","volume":"14","author":"Barr","year":"1995","journal-title":"Pediatr Infect Dis J"},{"key":"2024110112225978800_dkae028-B31","first-page":"1153","article-title":"Urinary recovery after ingestion of ampicillin tablets together with a standard breakfast as compared with administration to fasting subjects","volume":"38","author":"Bauer","year":"1976","journal-title":"Pharmazeutische Industrie"},{"key":"2024110112225978800_dkae028-B32","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1600-0773.1986.tb00105.x","article-title":"Oral absorption of flucloxacillin in infants and young children","volume":"58","author":"Bergdahl","year":"1986","journal-title":"Acta Pharmacol Toxicol (Copenh)"},{"key":"2024110112225978800_dkae028-B33","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1128\/AAC.33.3.291","article-title":"Pharmacokinetics of intravenous cefetamet (Ro 15-8074) and oral cefetamet pivoxil (Ro 15-8075) in young and elderly subjects","volume":"33","author":"Blouin","year":"1989","journal-title":"Antimicrob Agents Chemother"},{"key":"2024110112225978800_dkae028-B34","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1128\/AAC.34.9.1744","article-title":"Influence of antacid and ranitidine on the pharmacokinetics of oral cefetamet pivoxil","volume":"34","author":"Blouin","year":"1990","journal-title":"Antimicrob Agents Chemother"},{"key":"2024110112225978800_dkae028-B35","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1600-0773.1995.tb00140.x","article-title":"Malnutrition and pharmacokinetics of penicillin in Ethiopian children","volume":"76","author":"Bolme","year":"1995","journal-title":"Pharmacol Toxicol"},{"key":"2024110112225978800_dkae028-B36","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1128\/AAC.39.1.273","article-title":"Effect of food on absorption of cefpodoxime proxetil oral suspension in adults","volume":"39","author":"Borin","year":"1995","journal-title":"Antimicrob Agents Chemother"},{"key":"2024110112225978800_dkae028-B37","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/bdd.2510160405","article-title":"The bioavailability of cefpodoxime proxetil tablets relative to an oral solution","volume":"16","author":"Borin","year":"1995","journal-title":"Biopharm Drug Dispos"},{"key":"2024110112225978800_dkae028-B38","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/j.1552-4604.1995.tb04095.x","article-title":"Effect of timing of food on absorption of cefpodoxime proxetil","volume":"35","author":"Borin","year":"1995","journal-title":"J Clin Pharmacol"},{"key":"2024110112225978800_dkae028-B39","first-page":"1177","article-title":"Effect of food on pharmacokinetics of cefuroxime axetil in Chinese subjects","volume":"91","author":"Chen","year":"1992","journal-title":"J Formos Med Assoc"},{"key":"2024110112225978800_dkae028-B40","first-page":"219","article-title":"The relationship of food intake to the absorption of potassium alpha-phenoxyethyl penicillin and potassium phenoxymethyl penicillin from the gastrointestinal tract","volume":"240","author":"Cronk","year":"1960","journal-title":"Am J Med Sci"},{"key":"2024110112225978800_dkae028-B41","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1023\/A:1007568900147","article-title":"Bioequivalence study of stressed and nonstressed hard gelatin capsules using amoxicillin as a drug marker and gamma scintigraphy to confirm time and GI location of in vivo capsule rupture","volume":"17","author":"Digenis","year":"2000","journal-title":"Pharm Res"},{"key":"2024110112225978800_dkae028-B42","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/j.1365-2125.2011.04098.x","article-title":"The effect of staggered administration of zinc sulfate on the pharmacokinetics of oral cephalexin","volume":"73","author":"Ding","year":"2012","journal-title":"Br J Clin Pharmacol"},{"key":"2024110112225978800_dkae028-B43","first-page":"871","article-title":"A recent cephalosporin: cefadroxil. Clinical study and comparative blood levels after administration during fasting and after a meal","volume":"33","author":"Di Stefano","year":"1981","journal-title":"Minerva Pediatr"},{"key":"2024110112225978800_dkae028-B44","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.1128\/AAC.37.12.2706","article-title":"Bioavailability of syrup and tablet formulations of cefetamet pivoxil","volume":"37","author":"Ducharme","year":"1993","journal-title":"Antimicrob Agents Chemother"},{"key":"2024110112225978800_dkae028-B45","doi-asserted-by":"crossref","first-page":"e00618-19","DOI":"10.1128\/AAC.00618-19","article-title":"Safety, pharmacokinetics, and food effect of tebipenem pivoxil hydrobromide after single and multiple ascending oral doses in healthy adult subjects","volume":"63","author":"Eckburg","year":"2019","journal-title":"Antimicrob Agents Chemother"},{"key":"2024110112225978800_dkae028-B46","first-page":"2443","article-title":"Serum concentrations of penicillin V in children after peroral administration in two forms, fasting and at mealtimes","volume":"74","author":"Eden","year":"1977","journal-title":"Lakartidningen"},{"key":"2024110112225978800_dkae028-B47","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1128\/AAC.14.4.539","article-title":"Pharmacokinetics of amoxicillin and ampicillin: crossover study of the effect of food","volume":"14","author":"Eshelman","year":"1978","journal-title":"Antimicrob Agents Chemother"},{"key":"2024110112225978800_dkae028-B48","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jinf.2019.09.004","article-title":"Probenecid and food effects on flucloxacillin pharmacokinetics and pharmacodynamics in healthy volunteers","volume":"80","author":"Everts","year":"2020","journal-title":"J Infect"},{"key":"2024110112225978800_dkae028-B49","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/BF01046715","article-title":"The pharmacokinetics of cefixime in the fasted and fed state","volume":"34","author":"Faulkner","year":"1988","journal-title":"Eur J Clin Pharmacol"},{"key":"2024110112225978800_dkae028-B50","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1177\/030006057300100604","article-title":"The effect of food on the absorption of pivampicillin and a comparison with the absorption of ampicillin potassium","volume":"1","author":"Fernandez","year":"1973","journal-title":"J Int Med Res"},{"key":"2024110112225978800_dkae028-B51","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1600-0773.1981.tb00910.x","article-title":"The effect of food on the oral absorption of penicillin V preparations in children","volume":"49","author":"Finkel","year":"1981","journal-title":"Acta Pharmacol Toxicol (Copenh)"},{"key":"2024110112225978800_dkae028-B52","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/bdd.2510080604","article-title":"Effect of dose and food on the bioavailability of cefuroxime axetil","volume":"8","author":"Finn","year":"1987","journal-title":"Biopharm Drug Dispos"},{"key":"2024110112225978800_dkae028-B53","first-page":"1168","article-title":"Pharmacokinetic and clinical studies of cefdinir in the pediatric field","volume":"44","author":"Fujii","year":"1991","journal-title":"Jpn J Antibiot"},{"key":"2024110112225978800_dkae028-B54","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2165\/00003495-199100423-00011","article-title":"Clinical trials of cefpodoxime proxetil suspension in paediatrics","volume":"42","author":"Fujii","year":"1991","journal-title":"Drugs"},{"key":"2024110112225978800_dkae028-B55","first-page":"1592","article-title":"Overall clinical evaluation of cefprozil against infections in pediatric fields","volume":"45","author":"Fujii","year":"1992","journal-title":"Jpn J Antibiot"},{"key":"2024110112225978800_dkae028-B56","first-page":"849","article-title":"Pharmacological and clinical studies on the long acting cefaclor (S6472)","volume":"38","author":"Fujimoto","year":"1985","journal-title":"Jpn J Antibiot"},{"key":"2024110112225978800_dkae028-B57","doi-asserted-by":"crossref","first-page":"e0199370","DOI":"10.1371\/journal.pone.0199370","article-title":"In healthy volunteers, taking flucloxacillin with food does not compromise effective plasma concentrations in most circumstances","volume":"13","author":"Gardiner","year":"2018","journal-title":"PLoS One"},{"key":"2024110112225978800_dkae028-B58","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1128\/AAC.13.5.845","article-title":"Clinical pharmacology of cefadroxil in infants and children","volume":"13","author":"Ginsburg","year":"1978","journal-title":"Antimicrob Agents Chemother"},{"key":"2024110112225978800_dkae028-B59","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1542\/peds.64.5.627","article-title":"Comparative pharmacokinetics of amoxicillin and ampicillin in infants and children","volume":"64","author":"Ginsburg","year":"1979","journal-title":"Pediatrics"},{"key":"2024110112225978800_dkae028-B60","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1128\/AAC.16.1.74","article-title":"Pharmacokinetics of cephradine suspension infants and children","volume":"16","author":"Ginsburg","year":"1979","journal-title":"Antimicrob Agents Chemother"},{"key":"2024110112225978800_dkae028-B61","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1128\/AAC.19.6.1086","article-title":"Comparative pharmacokinetics of cyclacillin and amoxicillin in infants and children","volume":"19","author":"Ginsburg","year":"1981","journal-title":"Antimicrob Agents Chemother"},{"key":"2024110112225978800_dkae028-B62","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/jac\/10.suppl_B.27","article-title":"Comparative pharmacokinetics of cefadroxil, cefaclor, cephalexin and cephradine in infants and children","volume":"10","author":"Ginsburg","year":"1982","journal-title":"J Antimicrob Chemother"},{"key":"2024110112225978800_dkae028-B63","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1128\/AAC.28.4.504","article-title":"Pharmacokinetics and bactericidal activity of cefuroxime axetil","volume":"28","author":"Ginsburg","year":"1985","journal-title":"Antimicrob Agents Chemother"},{"key":"2024110112225978800_dkae028-B64","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1093\/jac\/15.3.345","article-title":"Pharmacokinetics and bactericidal activity of sultamicillin in infants and children","volume":"15","author":"Ginsburg","year":"1985","journal-title":"J Antimicrob Chemother"},{"key":"2024110112225978800_dkae028-B65","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/jac\/4.4.343","article-title":"A human pharmacology study of cefaclor","volume":"4","author":"Glynne","year":"1978","journal-title":"J Antimicrob Chemother"},{"key":"2024110112225978800_dkae028-B66","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3109\/00365529609031626","article-title":"Gastrointestinal transit of amoxicillin modified-release tablets and a placebo tablet including pharmacokinetic assessments of amoxicillin","volume":"31","author":"Gottfries","year":"1996","journal-title":"Scand J Gastroenterol"},{"key":"2024110112225978800_dkae028-B67","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1111\/j.1476-5381.1969.tb08513.x","article-title":"Cephalexin: human studies of absorption and excretion of a new cephalosporin antibiotic","volume":"37","author":"Gower","year":"1969","journal-title":"Br J Pharmacol"},{"key":"2024110112225978800_dkae028-B68","first-page":"315","article-title":"Bioavailability of new galenic preparations of cephalexin (author\u2019s transl)","volume":"13","author":"Guggenbichler","year":"1978","journal-title":"Padiatr Padol"},{"key":"2024110112225978800_dkae028-B69","first-page":"69","article-title":"Bioavailability of orally administered antibiotics: influences of food on resorption (author\u2019s transl)","volume":"14","author":"Guggenbichler","year":"1979","journal-title":"Padiatr Padol"},{"key":"2024110112225978800_dkae028-B70","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1111\/cts.13280","article-title":"Bioequivalence of two oral formulations of tebipenem pivoxil hydrobromide in healthy subjects","volume":"15","author":"Gupta","year":"2022","journal-title":"Clin Transl Sci"},{"key":"2024110112225978800_dkae028-B71","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.1248\/cpb.27.3156","article-title":"Evaluation of effect of food ingestion on bioavailability of cephalexin by moment analysis","volume":"27","author":"Haginaka","year":"1979","journal-title":"Chem Pharm Bull (Tokyo)"},{"key":"2024110112225978800_dkae028-B72","first-page":"337","article-title":"Influence of ethnic diets on ampicillin bioavailability and pharmacokinetics in healthy Pakistani subjects","volume":"39","author":"Hamid","year":"1987","journal-title":"Pol J Pharmacol Pharm"},{"key":"2024110112225978800_dkae028-B73","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1128\/AAC.25.1.78","article-title":"Pharmacology of cefuroxime as the 1-acetoxyethyl ester in volunteers","volume":"25","author":"Harding","year":"1984","journal-title":"Antimicrob Agents Chemother"},{"key":"2024110112225978800_dkae028-B74","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/j.1552-4604.1973.tb00066.x","article-title":"Cephradine absorption and excretion in fasting and nonfasting volunteers","volume":"13","author":"Harvengt","year":"1973","journal-title":"J Clin Pharmacol New Drugs"},{"key":"2024110112225978800_dkae028-B75","first-page":"655","article-title":"Absorption and excretion of cefradine in healthy volunteers (author\u2019s transl)","volume":"33","author":"Hayashi","year":"1980","journal-title":"Jpn J Antibiot"},{"key":"2024110112225978800_dkae028-B76","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1128\/AAC.33.11.1994","article-title":"Influence of an antacid containing aluminium and magnesium on the pharmacokinetics of cefixime","volume":"33","author":"Healy","year":"1989","journal-title":"Antimicrob Agents Chemother"},{"key":"2024110112225978800_dkae028-B77","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/clpt.1989.204","article-title":"The effects of gastric pH and food on the pharmacokinetics of a new oral cephalosporin, cefpodoxime proxetil","volume":"46","author":"Hughes","year":"1989","journal-title":"Clin Pharmacol Ther"},{"key":"2024110112225978800_dkae028-B78","first-page":"1571","article-title":"Pharmacokinetic, bacteriological and clinical evaluation of cefpodoxime proxetil in pediatrics","volume":"42","author":"Iwai","year":"1989","journal-title":"Jpn J Antibiot"},{"key":"2024110112225978800_dkae028-B79","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1128\/AAC.35.9.1860","article-title":"Pharmacokinetics of cefuroxime axetil and cefaclor: relationship of concentrations in serum to MICs for common respiratory pathogens","volume":"35","author":"James","year":"1991","journal-title":"Antimicrob Agents Chemother"},{"key":"2024110112225978800_dkae028-B80","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1159\/000237784","article-title":"Bioavailability and metabolism of talampicillin","volume":"24","author":"Jones","year":"1978","journal-title":"Chemotherapy"},{"key":"2024110112225978800_dkae028-B81","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3109\/inf.1974.6.issue-3.11","article-title":"Serum levels and clinical effect of flucloxacillin in patients with staphylococcal infections","volume":"6","author":"Kamme","year":"1974","journal-title":"Scand J Infect Dis"},{"key":"2024110112225978800_dkae028-B82","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/BF03190484","article-title":"The effect of four different types of food on the bioavailability of cefaclor","volume":"28","author":"Karim","year":"2003","journal-title":"Eur J Drug Metab Pharmacokinet"},{"key":"2024110112225978800_dkae028-B83","author":"Kassem"},{"key":"2024110112225978800_dkae028-B84","doi-asserted-by":"crossref","first-page":"363","DOI":"10.2133\/dmpk.17.363","article-title":"Lack of interaction between cefdinir and calcium polycarbophil: in vitro and in vivo studies","volume":"17","author":"Kato","year":"2002","journal-title":"Drug Metab Pharmacokinet"},{"key":"2024110112225978800_dkae028-B85","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1097\/00006454-199809000-00010","article-title":"Cefpodoxime pharmacokinetics in children: effect of food","volume":"17","author":"Kearns","year":"1998","journal-title":"Pediatric Infect Dis J"},{"key":"2024110112225978800_dkae028-B86","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/BF03190587","article-title":"Comparative effect of different types of food on the bioavailability of cefaclor extended release tablet","volume":"29","author":"Khan","year":"2004","journal-title":"Eur J Drug Metab Pharmacokinet"},{"key":"2024110112225978800_dkae028-B87","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1080\/10601330802064272","article-title":"Comparison of effect of fasting and of five different diets on the bioavailability of single oral dose of amoxicillin 500\u2005mg capsule","volume":"25","author":"Khuroo","year":"2008","journal-title":"Clin Res Regul Aff"},{"key":"2024110112225978800_dkae028-B88","first-page":"1424","article-title":"Laboratory and clinical studies on cefdinir in pediatric field","volume":"43","author":"Kibayashi","year":"1990","journal-title":"Jpn J Antibiot"},{"key":"2024110112225978800_dkae028-B89","first-page":"1593","article-title":"Bacteriological, pharmacokinetic and clinical studies on cefpodoxime proxetil in the pediatric field","volume":"42","author":"Kimura","year":"1989","journal-title":"Jpn J Antibiot"},{"key":"2024110112225978800_dkae028-B90","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1128\/AAC.32.4.573","article-title":"Pharmacokinetics of cefetamet (Ro 15-8074) and cefetamet pivoxil (Ro 15-8075) after intravenous and oral doses in humans","volume":"32","author":"Koup","year":"1988","journal-title":"Antimicrob Agents Chemother"},{"key":"2024110112225978800_dkae028-B91","first-page":"55","article-title":"Clinical phase I study of T-2588","volume":"40","author":"Koyama","year":"1986","journal-title":"Jpn J Antibiot"},{"key":"2024110112225978800_dkae028-B92","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1002\/cpdd.991","article-title":"An open-label, randomized, 2-way, crossover bioequivalence study of cefradine capsules in healthy Chinese volunteers","volume":"10","author":"Lai","year":"2021","journal-title":"Clin Pharmacol Drug Dev"},{"key":"2024110112225978800_dkae028-B93","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1128\/AAC.18.5.656","article-title":"Pharmacokinetic comparison of cefroxadin (CGP 9000) and cephalexin by simultaneous administration to humans","volume":"18","author":"Lecaillon","year":"1980","journal-title":"Antimicrob Agents Chemother"},{"key":"2024110112225978800_dkae028-B94","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1136\/bmj.1.6022.1378","article-title":"Talampicillin: a new derivative of ampicillin","volume":"1","author":"Leigh","year":"1976","journal-title":"Br Med J"},{"key":"2024110112225978800_dkae028-B95","first-page":"131","article-title":"Phase I clinical trial of cefditoren pivoxil (ME1207). Tolerance in healthy volunteers","volume":"23","author":"Li","year":"1997","journal-title":"Drugs Exp Clin Res"},{"key":"2024110112225978800_dkae028-B96","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1128\/AAC.00774-08","article-title":"Effects of cranberry juice on pharmacokinetics of \u03b2-lactam antibiotics following oral administration","volume":"53","author":"Li","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"2024110112225978800_dkae028-B97","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1080\/09291016.2011.652862","article-title":"Chronokinetic study of cefprozil in postprandial and fasting volunteers","volume":"44","author":"Li","year":"2013","journal-title":"Biol Rhythm Res"},{"key":"2024110112225978800_dkae028-B98","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1007\/s12325-020-01593-7","article-title":"Pharmacokinetics and bioequivalence of cefprozil for suspension and granule formulation in healthy Chinese volunteers: two single-dose crossover studies","volume":"38","author":"Lin","year":"2020","journal-title":"Adv Ther"},{"key":"2024110112225978800_dkae028-B99","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/AAC.16.1.1","article-title":"Comparative pharmacokinetics of cephalexin, cefaclor, cefadroxil, and CGP 9000","volume":"16","author":"Lode","year":"1979","journal-title":"Antimicrob Agents Chemother"},{"key":"2024110112225978800_dkae028-B100","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1007\/BF01659745","article-title":"Pharmacokinetics of cefaclor and initial therapeutical experience (author\u2019s transl)","volume":"7","author":"Lode","year":"1979","journal-title":"Infection"},{"key":"2024110112225978800_dkae028-B101","doi-asserted-by":"crossref","first-page":"725","DOI":"10.5414\/CP203986","article-title":"Bioequivalence of cefalexin in healthy Chinese subjects","volume":"59","author":"Lv","year":"2021","journal-title":"Int J Clin Pharmacol Ther"},{"key":"2024110112225978800_dkae028-B102","first-page":"109","volume-title":"Penicillins and Cephalosporins","author":"Magni","year":"1975"},{"key":"2024110112225978800_dkae028-B103","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1097\/00007691-200504000-00096","article-title":"Comparison of cefaclor absorption characteristics from the suspension and modified-release tablets in fast and fed condition","volume":"27","author":"Marzec","year":"2005","journal-title":"Ther Drug Monit"},{"key":"2024110112225978800_dkae028-B104","first-page":"98","article-title":"Laboratory and clinical studies on cephradine","volume":"23","author":"Matsumoto","year":"1975","journal-title":"Chemotherapy"},{"key":"2024110112225978800_dkae028-B105","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1056\/NEJM196008182630701","article-title":"Absorption and excretion of four penicillins","volume":"263","author":"McCarthy","year":"1960","journal-title":"N Engl J Med"},{"key":"2024110112225978800_dkae028-B106","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1542\/peds.62.5.738","article-title":"Pharmacologic evaluation of orally administered antibiotics in infants and children: effect of feeding on bioavailability","volume":"62","author":"McCracken","year":"1978","journal-title":"Pediatrics"},{"key":"2024110112225978800_dkae028-B107","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/jac\/4.6.515","article-title":"Pharmacokinetics of cefaclor in infants and children","volume":"4","author":"McCracken","year":"1978","journal-title":"J Antimicrob Chemother"},{"key":"2024110112225978800_dkae028-B108","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1002\/cpt1969106810","article-title":"Cephalexin: microbiological effects and pharmacologic parameters in man","volume":"10","author":"Meyers","year":"1969","journal-title":"Clin Pharmacol Ther"},{"key":"2024110112225978800_dkae028-B109","first-page":"1508","article-title":"Comparative study of serum concentrations of amoxicillin, pivampicillin and hetacillin (Dutch)","volume":"118","author":"Michel","year":"1974","journal-title":"Ned Tijdschr Geneeskd"},{"key":"2024110112225978800_dkae028-B110","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/j.1552-4604.1974.tb01380.x","article-title":"Influence of probenecid and food on the bioavailability of cephradine in normal male subjects","volume":"14","author":"Mischler","year":"1974","journal-title":"J Clin Pharmacol"},{"key":"2024110112225978800_dkae028-B111","first-page":"74","article-title":"Pharmacokinetics and clinical effects of cefdinir 10% fine granules in pediatrics","volume":"45","author":"Motohiro","year":"1992","journal-title":"Jpn J Antibiot"},{"key":"2024110112225978800_dkae028-B112","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/BF01739307","article-title":"Absorption of pivampicillin as related to dose, and tolerability of a 700 mg tablet","volume":"21","author":"Munkholm","year":"1993","journal-title":"Infection"},{"key":"2024110112225978800_dkae028-B113","first-page":"1874","article-title":"Studies on sultamicillin in the field of pediatrics","volume":"41","author":"Nakamura","year":"1988","journal-title":"Jpn J Antibiot"},{"key":"2024110112225978800_dkae028-B114","first-page":"1981","article-title":"Pharmacokinetic studies on oral antibiotics in pediatrics. II. A pharmacokinetic study on cefteram pivoxil in pediatrics","volume":"42","author":"Nakamura","year":"1989","journal-title":"Jpn J Antibiot"},{"key":"2024110112225978800_dkae028-B115","first-page":"964","article-title":"Pharmacokinetic study on oral antibiotics in pediatrics. I. A pharmacokinetic study on cefixime in pediatrics","volume":"44","author":"Nakamura","year":"1991","journal-title":"Jpn J Antibiot"},{"key":"2024110112225978800_dkae028-B116","first-page":"12","article-title":"Pharmacokinetic study on oral antibiotics in pediatrics. V. A pharmacokinetic study on cefdinir in pediatrics","volume":"45","author":"Nakamura","year":"1992","journal-title":"Jpn J Antibiot"},{"key":"2024110112225978800_dkae028-B117","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/j.1552-4604.1987.tb03043.x","article-title":"Phase I study of cefixime, a new oral cephalosporin","volume":"27","author":"Nakashima","year":"1987","journal-title":"J Clin Pharmacol"},{"key":"2024110112225978800_dkae028-B118","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/j.1552-4604.1988.tb03140.x","article-title":"Phase I clinical studies of 7432-S, a new oral cephalosporin: safety and pharmacokinetics","volume":"28","author":"Nakashima","year":"1988","journal-title":"J Clin Pharmacol"},{"key":"2024110112225978800_dkae028-B119","first-page":"136","article-title":"Effect of diet on the pharmacokinetics of tebipenem pivoxil fine granules in healthy male volunteers","volume":"62","author":"Nakashima","year":"2009","journal-title":"Jpn J Antibiot"},{"key":"2024110112225978800_dkae028-B120","first-page":"95","article-title":"Effect of diet including ice cream and pudding on tebipenem pivoxil fine granules pharmacokinetics in healthy male volunteers","volume":"57","author":"Nakashima","year":"2009","journal-title":"Jpn J Chemother"},{"key":"2024110112225978800_dkae028-B121","first-page":"82","article-title":"Pharmacokinetics and safety of oral carbapenem antibiotic tebipenem pivoxil tablets in healthy male volunteers","volume":"57","author":"Nakashima","year":"2009","journal-title":"Jpn J Chemother"},{"key":"2024110112225978800_dkae028-B122","first-page":"103","article-title":"Effect of probenecid or diet on tebipenem pivoxil tablets pharmacokinetics in healthy male volunteers","volume":"57","author":"Nakashima","year":"2009","journal-title":"Jpn J Chemother"},{"key":"2024110112225978800_dkae028-B123","doi-asserted-by":"crossref","first-page":"S123","DOI":"10.1093\/infdis\/129.Supplement_2.S123","article-title":"Antimicrobial activity and human pharmacology of amoxicillin","volume":"129","author":"Neu","year":"1974","journal-title":"J Infect Dis"},{"key":"2024110112225978800_dkae028-B124","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1093\/clinids\/3.1.110","article-title":"The pharmacokinetics of bacampicillin","volume":"3","author":"Neu","year":"1981","journal-title":"Rev Infect Dis"},{"key":"2024110112225978800_dkae028-B125","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1177\/030006057700500113","article-title":"Comparative effect of food on absorption of ampicillin and pivampicillin","volume":"5","author":"Neuvonen","year":"1977","journal-title":"J Int Med Res"},{"key":"2024110112225978800_dkae028-B126","first-page":"1634","article-title":"Laboratory and clinical studies of cefroxadine","volume":"34","author":"Nishimura","year":"1981","journal-title":"Jpn J Antibiot"},{"key":"2024110112225978800_dkae028-B127","author":"FDA"},{"key":"2024110112225978800_dkae028-B128","author":"FDA"},{"key":"2024110112225978800_dkae028-B129","author":"FDA"},{"key":"2024110112225978800_dkae028-B130","author":"FDA"},{"key":"2024110112225978800_dkae028-B131","author":"FDA"},{"key":"2024110112225978800_dkae028-B132","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1128\/AAC.35.9.1729","article-title":"Pharmacokinetic analysis of the effects of different foods on absorption of cefaclor","volume":"35","author":"Oguma","year":"1991","journal-title":"Antimicrob Agents Chemother"},{"key":"2024110112225978800_dkae028-B133","first-page":"7","article-title":"Pharmacokinetic interaction between antacid and commonly prescribed medications - metformin, diclofenac and amoxicillin","volume":"3","author":"Olaganathan","year":"2017","journal-title":"Eur J Mol Clin Med"},{"key":"2024110112225978800_dkae028-B134","doi-asserted-by":"crossref","first-page":"406P","DOI":"10.1111\/j.1365-2125.1977.tb00752.x","article-title":"The effect of a Lundh meal on the plasma concentration\/time curve of ampicillin, amoxycillin, pivampicillin and cephalexin in normal subjects","volume":"4","author":"Parsons","year":"1977","journal-title":"Br J Clin Pharmacol"},{"key":"2024110112225978800_dkae028-B135","doi-asserted-by":"crossref","first-page":"e0149522","DOI":"10.1128\/aac.01495-22","article-title":"Effect of an antacid (aluminum hydroxide\/magnesium hydroxide\/simethicone) or a proton pump inhibitor (omeprazole) on the pharmacokinetics of tebipenem pivoxil hydrobromide (TBP-PI-HBr) in healthy adult subjects","volume":"67","author":"Patel","year":"2023","journal-title":"Antimicrob Agents Chemother"},{"key":"2024110112225978800_dkae028-B136","first-page":"1596","article-title":"Pharmacokinetic interaction of cefixime and 2 antacids. Preliminary results","volume":"18","author":"Petitjean","year":"1989","journal-title":"Presse Med"},{"key":"2024110112225978800_dkae028-B137","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1128\/AAC.11.2.331","article-title":"Comparative human oral clinical pharmacology of cefadroxil, cephalexin, and cephradine","volume":"11","author":"Pfeffer","year":"1977","journal-title":"Antimicrob Agents Chemother"},{"key":"2024110112225978800_dkae028-B138","doi-asserted-by":"crossref","first-page":"1012294","DOI":"10.3389\/fphar.2022.1012294","article-title":"Pharmacokinetics and safety of the two oral cefaclor formulations in healthy Chinese subjects in the fasting and postprandial states","volume":"13","author":"Qu","year":"2022","journal-title":"Front Pharmacol"},{"key":"2024110112225978800_dkae028-B139","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1097\/00045391-199803000-00003","article-title":"Pharmacokinetic drug interaction study: administration of ceftibuten concurrently with the antacid Mylanta double-strength liquid or with ranitidine","volume":"5","author":"Radwanski","year":"1998","journal-title":"Am J Ther"},{"key":"2024110112225978800_dkae028-B140","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1128\/AAC.6.5.563","article-title":"Clinical pharmacology of pivampicillin","volume":"6","author":"Roholt","year":"1974","journal-title":"Antimicrob Agents Chemother"},{"key":"2024110112225978800_dkae028-B141","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1128\/AAC.36.4.796","article-title":"Of cefpodoxime proxetil and interactions with an antacid and an H2 receptor antagonist","volume":"36","author":"Saathoff","year":"1992","journal-title":"Antimicrob Agents Chemother"},{"key":"2024110112225978800_dkae028-B142","doi-asserted-by":"crossref","first-page":"537","DOI":"10.5694\/j.1326-5377.1973.tb129635.x","article-title":"Evaluation of amoxycillin\u2014a new semisynthetic penicillin","volume":"2","author":"Sabto","year":"1973","journal-title":"Med J Aust"},{"key":"2024110112225978800_dkae028-B143","doi-asserted-by":"crossref","first-page":"458","DOI":"10.11150\/kansenshogakuzasshi1970.49.458","article-title":"Studies on talampicillin","volume":"49","author":"Saito","year":"1975","journal-title":"Kansenshogaku Zasshi"},{"key":"2024110112225978800_dkae028-B144","first-page":"446","article-title":"Clinical trials of sultamicillin (ester of sulbactam-ampicillin) on the skin and soft tissue infections in the field of surgery","volume":"33","author":"Sakai","year":"1985","journal-title":"Chemotherapy"},{"key":"2024110112225978800_dkae028-B145","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1128\/AAC.13.6.951","article-title":"Pharmacology of cefaclor in normal volunteers and patients with renal failure","volume":"13","author":"Santoro","year":"1978","journal-title":"Antimicrob Agents Chemother"},{"key":"2024110112225978800_dkae028-B146","first-page":"430","article-title":"Penicillin VK absorption during fasting and after eating","volume":"117","author":"Sarel","year":"1989","journal-title":"Harefuah"},{"key":"2024110112225978800_dkae028-B147","first-page":"S3","article-title":"Pharmacokinetics of cefaclor AF: effects of age, antacids and H2-receptor antagonists","volume":"68","author":"Satterwhite","year":"1992","journal-title":"Postgrad Med J"},{"key":"2024110112225978800_dkae028-B148","first-page":"1310","article-title":"Effects of antacids on pharmacokinetics of cefditoren pivoxil and its metabolism in humans","volume":"40","author":"Shiba","year":"1992","journal-title":"Chemotherapy"},{"key":"2024110112225978800_dkae028-B149","first-page":"340","article-title":"Effect of food intake on pharmacokinetics of cefetamet pivoxil","volume":"38","author":"Shiiki","year":"1990","journal-title":"Chemotherapy"},{"key":"2024110112225978800_dkae028-B150","first-page":"246","article-title":"Effect of food on bioavailability of cefdinir","volume":"37","author":"Shimada","year":"1989","journal-title":"Chemotherapy"},{"key":"2024110112225978800_dkae028-B151","first-page":"1353","article-title":"Effects of antacids on absorption, excretion and metabolism of cefteram pivoxil","volume":"43","author":"Shimada","year":"1990","journal-title":"Jpn J Antibiot"},{"key":"2024110112225978800_dkae028-B152","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1002\/j.1552-4604.1992.tb03876.x","article-title":"Pharmacokinetic interactions of cefprozil with food, propantheline, metoclopramide, and probenecid in healthy volunteers","volume":"32","author":"Shukla","year":"1992","journal-title":"J Clin Pharmacol"},{"key":"2024110112225978800_dkae028-B153","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1136\/bmj.2.5555.804","article-title":"Laboratory and pharmacological studies in man with hetacillin and ampicillin","volume":"2","author":"Sutherland","year":"1967","journal-title":"Br Med J"},{"key":"2024110112225978800_dkae028-B154","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1128\/AAC.36.5.938","article-title":"Excretion of cefprozil into human breast milk","volume":"36","author":"Shyu","year":"1992","journal-title":"Antimicrob Agents Chemother"},{"key":"2024110112225978800_dkae028-B155","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/cpt19645126","article-title":"Cloxacillin, a new oral synthetic penicillin comparisons with oxacillin","volume":"5","author":"Sidell","year":"1964","journal-title":"Clin Pharmacol Ther"},{"key":"2024110112225978800_dkae028-B156","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/j.1365-2125.1984.tb02501.x","article-title":"Influence of food and reduced gastric acidity on the bioavailability of bacampicillin and cefuroxime axetil","volume":"18","author":"Sommers","year":"1984","journal-title":"Br J Clin Pharmacol"},{"key":"2024110112225978800_dkae028-B157","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1093\/jac\/10.2.131","article-title":"Effect of food on the bioavailability and tolerance of clavulanic acid\/amoxycillin combination","volume":"10","author":"Staniforth","year":"1982","journal-title":"J Antimicrob Chemother"},{"key":"2024110112225978800_dkae028-B158","first-page":"154","article-title":"Augmentin bioavailability following cimetidine, aluminum hydroxide and milk","volume":"23","author":"Staniforth","year":"1985","journal-title":"Int J Clin Pharmacol"},{"key":"2024110112225978800_dkae028-B159","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1128\/AAC.34.8.1556","article-title":"Effects of timing of food and fluid volume on cefetamet pivoxil absorption in healthy normal volunteers","volume":"34","author":"Tam","year":"1990","journal-title":"Antimicrob Agents Chemother"},{"key":"2024110112225978800_dkae028-B160","first-page":"834","article-title":"Absorption and excretion studies of S6472 (sustained release preparations of cefaclor)","volume":"38","author":"Tateno","year":"1985","journal-title":"Jpn J Antibiot"},{"key":"2024110112225978800_dkae028-B161","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0022-3476(78)80029-8","article-title":"Bioavailability of cephalexin in children: relationship to drug formulations and meals","volume":"92","author":"Tetzlaff","year":"1978","journal-title":"J Pediatr"},{"key":"2024110112225978800_dkae028-B162","doi-asserted-by":"crossref","first-page":"3735","DOI":"10.1016\/j.xphs.2021.06.011","article-title":"Pharmacokinetics and bioequivalence of two amoxicillin 500\u2005mg products: effect of food on absorption and supporting scientific justification for biowaiver","volume":"110","author":"Thambavita","year":"2021","journal-title":"J Pharm Sci"},{"key":"2024110112225978800_dkae028-B163","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0924-8579(01)00443-5","article-title":"Effects of food intake and age on the pharmacokinetics of AS-924, a novel ester-type cephem antibiotic. Comparison with cefpodoxime proxetil","volume":"18","author":"Totsuka","year":"2001","journal-title":"Int J Antimicrob Agents"},{"key":"2024110112225978800_dkae028-B164","first-page":"373","article-title":"Fundamental and clinical studies on BRL 25000 (clavulanic acid-amoxicillin) granules in the pediatric field","volume":"38","author":"Toyonaga","year":"1985","journal-title":"Jpn J Antibiot"},{"key":"2024110112225978800_dkae028-B165","first-page":"1799","article-title":"Bacteriological, pharmacokinetic and clinical studies on cefteram pivoxil in the pediatric field","volume":"42","author":"Toyonaga","year":"1989","journal-title":"Jpn J Antibiot"},{"key":"2024110112225978800_dkae028-B166","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/clpt.1993.178","article-title":"Impairment of cefdinir absorption by iron ion","volume":"54","author":"Ueno","year":"1993","journal-title":"Clin Pharmacol Ther"},{"key":"2024110112225978800_dkae028-B167","first-page":"1735","article-title":"Clinical evaluation of cefteram pivoxil fine granules in pediatric infections","volume":"42","author":"Wagatsuma","year":"1989","journal-title":"Jpn J Antibiot"},{"key":"2024110112225978800_dkae028-B168","first-page":"1464","article-title":"A clinical study on cefpodoxime proxetil dry syrup in pediatric infections","volume":"42","author":"Wagatsuma","year":"1989","journal-title":"Jpn J Antibiot"},{"key":"2024110112225978800_dkae028-B169","first-page":"556","article-title":"Effect of food intake on pharmacokinetics of sustained-release cefradine capsules in healthy volunteers","volume":"36","author":"Wang","year":"2005","journal-title":"J China Pharm Univ"},{"key":"2024110112225978800_dkae028-B170","doi-asserted-by":"crossref","first-page":"966","DOI":"10.36468\/pharmaceutical-sciences.592","article-title":"Diet-induced alterations in pharmacokinetics of cefuroxime axetil in healthy Chinese subjects","volume":"81","author":"Wang","year":"2019","journal-title":"Indian J Pharm Sci"},{"key":"2024110112225978800_dkae028-B171","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.ejpb.2008.05.011","article-title":"Bioavailability of amoxicillin and clavulanic acid from extended release tablets depends on intragastric tablet deposition and gastric emptying","volume":"70","author":"Weitschies","year":"2008","journal-title":"Eur J Pharm Biopharm"},{"key":"2024110112225978800_dkae028-B172","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1002\/jps.2600660423","article-title":"Bioavailability of ampicillin and amoxicillin in fasted and nonfasted subjects","volume":"66","author":"Welling","year":"1977","journal-title":"J Pharm Sci"},{"key":"2024110112225978800_dkae028-B173","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/jac\/13.2.191","article-title":"The absolute bioavailability of oral cefuroxime axetil in male and female volunteers after fasting and after food","volume":"13","author":"Williams","year":"1984","journal-title":"J Antimicrob Chemother"},{"key":"2024110112225978800_dkae028-B174","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1002\/cpdd.1143","article-title":"Pharmacokinetics of amoxicillin and clavulanate potassium for suspension (200 mg\/28.5 mg) in healthy subjects: sample add stabilizer study and food effects","volume":"11","author":"Xu","year":"2022","journal-title":"Clin Pharmacol Drug Dev"},{"key":"2024110112225978800_dkae028-B175","first-page":"99","article-title":"Comparative study on human blood concentration of oral cephem antibiotics CXM-AX vs CCL - effect of food on bioavailability","volume":"11","author":"Yamaguchi","year":"1992","journal-title":"Oral Ther Pharmacol"},{"key":"2024110112225978800_dkae028-B176","first-page":"1531","article-title":"Effects of high-fat and high-calorie diets on pharmacokinetics of cefuroxime axetil tablets","volume":"52","author":"Yang","year":"2017","journal-title":"Chin Pharm J"},{"key":"2024110112225978800_dkae028-B177","first-page":"293","article-title":"Pharmacokinetics of cefixime in healthy volunteers","volume":"19","author":"Yaoguo","year":"1994","journal-title":"Chin J Antibiotics"},{"key":"2024110112225978800_dkae028-B178","first-page":"e295-6","article-title":"Bioavailability of amoxicillin dissolved in human milk","volume":"19","author":"Yazdani-Brojeni","year":"2012","journal-title":"J Popul Ther Clin Pharmacol"},{"key":"2024110112225978800_dkae028-B179","first-page":"740","article-title":"Bioequivalence of cefdinir capsules in Chinese healthy population under fasting\/high-fat fed condition","volume":"25","author":"Zhang","year":"2020","journal-title":"Chin J Clin Pharmacol Therapeutics"},{"key":"2024110112225978800_dkae028-B180","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1007\/s10461-022-03880-6","article-title":"Interactions of antiretroviral drugs with food, beverages, dietary supplements, and alcohol: a systematic review and meta-analyses","volume":"27","author":"Wiesner","year":"2023","journal-title":"AIDS Behav"},{"key":"2024110112225978800_dkae028-B181","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/jphp.12957","article-title":"Food for thought: formulating away the food effect\u2014a PEARRL review","volume":"71","author":"O\u2019Shea","year":"2019","journal-title":"J Pharm Pharmacol"},{"key":"2024110112225978800_dkae028-B182","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/ja.2011.58","article-title":"Recent advances in materials for extended-release antibiotic delivery system","volume":"64","author":"Gao","year":"2011","journal-title":"J Antibiot"},{"key":"2024110112225978800_dkae028-B183","first-page":"s6","article-title":"Modified-release formulations: improving efficacy and patient compliance","volume":"2019","author":"Gorria","year":"2019","journal-title":"Pharm Technol"},{"key":"2024110112225978800_dkae028-B184","doi-asserted-by":"crossref","first-page":"36991196","DOI":"10.1208\/s12248-023-00804-7","article-title":"Predicting food effects on oral extended-release drug products: a retrospective evaluation","volume":"25","author":"Zou","year":"2023","journal-title":"AAPS J"},{"key":"2024110112225978800_dkae028-B185","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/B978-1-4377-0310-8.00002-6","volume-title":"Applied Pharmacology","author":"Bardal","year":"2011"},{"key":"2024110112225978800_dkae028-B186","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3390\/ph14030206","article-title":"Levothyroxine interactions with food and dietary supplements\u2014a systematic review","volume":"40","author":"Wiesner","year":"2021","journal-title":"Pharmaceuticals"},{"key":"2024110112225978800_dkae028-B187","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/bcp.12267","article-title":"Paediatric pharmacokinetics: key considerations","volume":"79","author":"Batchelor","year":"2015","journal-title":"Br J Clin Pharmacol"},{"key":"2024110112225978800_dkae028-B188","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1021\/acsinfecdis.8b00160","article-title":"Pharmacokinetics of \u03b2-lactam antibiotics: clues from the past to help discover long-acting oral drugs in the future","volume":"4","author":"Smith","year":"2018","journal-title":"ACS Infect Dis"},{"key":"2024110112225978800_dkae028-B189","doi-asserted-by":"crossref","first-page":"5691","DOI":"10.1021\/acs.jmedchem.5b00201","article-title":"Volume of distribution in drug design","volume":"58","author":"Smith","year":"2015","journal-title":"J Med Chem"},{"key":"2024110112225978800_dkae028-B190","volume-title":"StatPearls","author":"Onetto","year":"2023"},{"key":"2024110112225978800_dkae028-B191","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.accpm.2019.07.016","article-title":"Pharmacokinetic variability of beta-lactams in critically ill patients: a narrative review","volume":"39","author":"Boidin","year":"2020","journal-title":"Anaesth Crit Care Pain Med"},{"key":"2024110112225978800_dkae028-B192","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/BF03189714","article-title":"The influence of food on the absorption and metabolism of drugs: an update","volume":"21","author":"Williams","year":"1996","journal-title":"Eur J Drug Metab Pharmacokinet"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jac\/article-pdf\/79\/4\/722\/60289878\/dkae028.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jac\/article-pdf\/79\/4\/722\/60289878\/dkae028.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T12:23:38Z","timestamp":1730463818000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article\/79\/4\/722\/7604318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,9]]},"references-count":192,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,2,9]]},"published-print":{"date-parts":[[2024,4,2]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dkae028","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,4]]},"published":{"date-parts":[[2024,2,9]]}}}