{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:49:57Z","timestamp":1792684197557,"version":"4.5.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To compare the efficacy of temocillin with standard of care (SOC) for treatment of ESBL-producing Enterobacteriaceae (ESBL-E) febrile urinary tract infection (ESBL-E FUTI) in children.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A monocentric retrospective study of children hospitalized with confirmed ESBL-E FUTI from January 2015 to May 2022 was conducted, comparing clinical cure and a 3\u2005month relapse between two groups of patients: \u2018exposed\u2019 patients (EP) and \u2018non-exposed\u2019 patients (NEP) to temocillin. EP received temocillin for at least 3\u2005days. They were matched (1:1 ratio) on age group, sex and presence of uropathy with NEP who received SOC antibiotic therapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Thirty-six temocillin-treated children (EP) were matched with 36 SOC children (NEP); 72.2% were under 2\u2005years old (n\u200a=\u200a52) and 75.0% had a congenital uropathy (n\u200a=\u200a54). EPs had more FUTI history (97.2%, n\u200a=\u200a35) than NEPs (61.1%, n\u200a=\u200a22) (P\u200a&amp;lt;\u200a0.01). Clinical cure rate was 98.6% overall, with no difference between the two groups, as for the FUTI relapse rate, which was 37.1% for EPs versus 27.8% for NEPs (P\u200a=\u200a0.45). In bivariate analyses, factors associated with relapses were congenital uropathy (91.3% versus 66.7%, P\u200a=\u200a0.04) and subtypes of uropathy, with refluxing uropathy and posterior urethral valves being the more prevalent. Median duration of hospitalization was longer in the EPs (8.0 versus 5.0\u2005days) (P\u200a=\u200a0.01).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The high clinical cure rate and comparable outcomes suggest that temocillin may be an effective therapeutic alternative to standard treatment for ESBL-E FUTI in children.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkae053","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T20:20:26Z","timestamp":1709065226000},"page":"918-922","source":"Crossref","is-referenced-by-count":3,"title":["Temocillin for febrile urinary tract infections caused by ESBL-producing Enterobacteriaceae in children: a monocentric exposed\/non-exposed study"],"prefix":"10.1093","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4772-9826","authenticated-orcid":false,"given":"Jules","family":"Bayart","sequence":"first","affiliation":[{"name":"Service de P\u00e9diatrie G\u00e9n\u00e9rale, H\u00f4pital Robert-Debr\u00e9, AP-HP , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4164-6022","authenticated-orcid":false,"given":"Juliette","family":"Drouet","sequence":"additional","affiliation":[{"name":"INSERM, Institut Pierre Louis d\u2019\u00c9pid\u00e9miologie et de Sant\u00e9 Publique, Sorbonne Universit\u00e9 , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3617-4849","authenticated-orcid":false,"given":"Matthieu","family":"Peycelon","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery and Urology, APHP North-Universit\u00e9 Paris Cit\u00e9. Robert-Debr\u00e9 University Hospital, Centre de R\u00e9f\u00e9rence des Malformations Rares des Voies Urinaires (MARVU), ERN eUROGEN accredited center , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Mariani","sequence":"additional","affiliation":[{"name":"Service de Microbiologie, H\u00f4pital Robert-Debr\u00e9, AP-HP , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2238-7133","authenticated-orcid":false,"given":"Enora","family":"Le Roux","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche Clinique, H\u00f4pital Robert-Debr\u00e9, AP-HP , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7704-9628","authenticated-orcid":false,"given":"Maya","family":"Husain","sequence":"additional","affiliation":[{"name":"Service de P\u00e9diatrie G\u00e9n\u00e9rale, H\u00f4pital Robert-Debr\u00e9, AP-HP , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Agar","sequence":"additional","affiliation":[{"name":"Service de Pharmacie \u00e0 Usage Int\u00e9rieur, H\u00f4pital Robert-Debr\u00e9, AP-HP , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Bonacorsi","sequence":"additional","affiliation":[{"name":"Service de Microbiologie, H\u00f4pital Robert-Debr\u00e9, AP-HP , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3985-5717","authenticated-orcid":false,"given":"Marion","family":"Caseris","sequence":"additional","affiliation":[{"name":"Service de P\u00e9diatrie G\u00e9n\u00e9rale, H\u00f4pital Robert-Debr\u00e9, AP-HP , Paris , 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