{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T09:12:29Z","timestamp":1787994749839,"version":"build-2784847793"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T00:00:00Z","timestamp":1711065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"\u00d6rebro County Council Research Committe"},{"name":"Foundation for Medical Research at \u00d6rebro University Hospital, \u00d6rebro, Sweden"},{"DOI":"10.13039\/501100006506","name":"Brazilian Ministry of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006506","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Regular quality-assured WGS with antimicrobial resistance (AMR) and epidemiological data of patients is imperative to elucidate the shifting gonorrhoea epidemiology, nationally and internationally. We describe the dynamics of the gonococcal population in 11 cities in Brazil between 2017 and 2020 and elucidate emerging and disappearing gonococcal lineages associated with AMR, compare to Brazilian WGS and AMR data from 2015 to 2016, and explain recent changes in gonococcal AMR and gonorrhoea epidemiology.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>WGS was performed using Illumina NextSeq 550 and genomes of 623 gonococcal isolates were used for downstream analysis. Molecular typing and AMR determinants were obtained and links between genomic lineages and AMR (determined by agar dilution\/Etest) examined.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Azithromycin resistance (15.6%, 97\/623) had substantially increased and was mainly explained by clonal expansions of strains with 23S rRNA C2611T (mostly NG-STAR CC124) and mtr mosaics (mostly NG-STAR CC63, MLST ST9363). Resistance to ceftriaxone and cefixime remained at the same levels as in 2015\u201316, i.e. at 0% and 0.2% (1\/623), respectively. Regarding novel gonorrhoea treatments, no known zoliflodacin-resistance gyrB mutations or gepotidacin-resistance gyrA mutations were found. Genomic lineages and sublineages showed a phylogenomic shift from sublineage A5 to sublineages A1\u2013A4, while isolates within lineage B remained diverse in Brazil.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Azithromycin resistance, mainly caused by 23S rRNA C2611T and mtrD mosaics\/semi-mosaics, had substantially increased in Brazil. This mostly low-level azithromycin resistance may threaten the recommended ceftriaxone-azithromycin therapy, but the lack of ceftriaxone resistance is encouraging. Enhanced gonococcal AMR surveillance, including WGS, is imperative in Brazil and other Latin American and Caribbean countries.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkae075","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T16:44:20Z","timestamp":1711125860000},"page":"1081-1092","source":"Crossref","is-referenced-by-count":8,"title":["Recent dynamics in <i>Neisseria gonorrhoeae<\/i> genomic epidemiology in Brazil: antimicrobial resistance and genomic lineages in 2017\u201320 compared to 2015\u201316"],"prefix":"10.1093","volume":"79","author":[{"given":"Daniel","family":"Golparian","sequence":"first","affiliation":[{"name":"WHO Collaborating Centre for Gonorrhoea and Other Sexually Transmitted Infections, Department of Laboratory Medicine, Microbiology, Faculty of Medicine and Health, \u00d6rebro University , SE-701 85, \u00d6rebro , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luiza","family":"Bazzo","sequence":"additional","affiliation":[{"name":"Molecular Biology, Microbiology and Serology Laboratory, Federal University of Santa Catarina , Florian\u00f3polis , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josefine","family":"Ahlstrand","sequence":"additional","affiliation":[{"name":"WHO Collaborating Centre for Gonorrhoea and Other Sexually Transmitted Infections, Department of Laboratory Medicine, Microbiology, Faculty of Medicine and Health, \u00d6rebro University , SE-701 85, \u00d6rebro , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Andr\u00e9","family":"Sch\u00f6rner","sequence":"additional","affiliation":[{"name":"Molecular Biology, Microbiology and Serology Laboratory, Federal University of Santa Catarina , Florian\u00f3polis , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela Cristina","family":"Gaspar","sequence":"additional","affiliation":[{"name":"Department of HIV\/AIDS, Tuberculosis, and Sexually Transmitted Infection, Secretariat of Health Surveillance and Environment, Ministry of Health of Brazil , Bras\u00edlia , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanalydia","family":"de Melo Machado","sequence":"additional","affiliation":[{"name":"Molecular Biology, Microbiology and Serology Laboratory, Federal University of Santa Catarina , Florian\u00f3polis , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9ssica Motta","family":"Martins","sequence":"additional","affiliation":[{"name":"Molecular Biology, Microbiology and Serology Laboratory, Federal University of Santa Catarina , Florian\u00f3polis , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisson","family":"Bigolin","sequence":"additional","affiliation":[{"name":"Department of HIV\/AIDS, Tuberculosis, and Sexually Transmitted Infection, Secretariat of Health Surveillance and Environment, Ministry of Health of Brazil , Bras\u00edlia , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro Cunha","family":"Ramos","sequence":"additional","affiliation":[{"name":"Brazilian STD Society , Porto Alegre , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William Antunes","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Alfredo da Mata Foundation , Manaus , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerson Fernando Mendes","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of HIV\/AIDS, Tuberculosis, and Sexually Transmitted Infection, Secretariat of Health Surveillance and Environment, Ministry of Health of Brazil , Bras\u00edlia , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelica Espinosa","family":"Miranda","sequence":"additional","affiliation":[{"name":"Department of HIV\/AIDS, Tuberculosis, and Sexually Transmitted Infection, Secretariat of Health Surveillance and Environment, Ministry of Health of Brazil , Bras\u00edlia , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1710-2081","authenticated-orcid":false,"given":"Magnus","family":"Unemo","sequence":"additional","affiliation":[{"name":"WHO Collaborating Centre for Gonorrhoea and Other Sexually Transmitted Infections, Department of Laboratory Medicine, Microbiology, Faculty of Medicine and Health, \u00d6rebro University , SE-701 85, \u00d6rebro , Sweden"},{"name":"Institute for Global Health, University College London (UCL) , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Brazilian-GASP Network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone Veloso Faria","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rita Rabelo","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciane Guimar\u00e3es","family":"Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana D'arc Pinheiro","family":"Feitosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Isabella","family":"Maciel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibele Corr\u00eaa","family":"Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elly Rodrigo","family":"Porto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidiane","family":"da Fonseca Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glaura Regina","family":"de Castro e Caldo Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviane Furlan","family":"Lozano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luiza","family":"Bazzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"de Rocco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Hartmann","family":"Barazzetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme","family":"Kerber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanalydia","family":"de Melo Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9ssica Motta","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ketlyn","family":"Buss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara Cristina","family":"Scheffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Andr\u00e9","family":"Sch\u00f6rner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronaldo","family":"Zonta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro Cunha","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rita Castilhos","family":"Nicola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cristina","family":"Cecconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara Suely Souza","family":"de Noronha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cleiby Andrade","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francinete Motta","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jairo","family":"de Souza Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamile Izan Lopes Palhesta","family":"J\u00fanior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Tadeu Cavalcante","family":"Saif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willian Antunes","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miralba","family":"Freire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Maur\u00edcio","family":"Costa Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe Nogueira M","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida","family":"Politano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto Jos\u00e9 Carvalho","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"de Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio Campos","family":"do Porto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta Alessandra Lima","family":"Bocalon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"de Oliveira Machado de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Mialski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keite","family":"da Silva Nogueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f4nica Baumgardt","family":"Bay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoella","family":"do Monte Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erianna Yadja Lucina","family":"de Macedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Cintra","family":"Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00edz Fernando Aires","family":"Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa","family":"de Oliveira Camargo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lis Aparecida","family":"de Souza Neves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula Luchetta","family":"Paes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Barufaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique Dib Oliveira","family":"Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz S\u00e9rgio","family":"D\u2019Oliveira Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta In\u00eas Cazentini","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana Rezende","family":"Amaral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois Jos\u00e9","family":"de Figueiroa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anesia Maria Siqueira","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Albertina","family":"Araujo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Goretti","family":"Varej\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Garnier","family":"de Fran\u00e7a Mendes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valdelucia Oliveira","family":"Cavalcanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Gabriel Lima","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Ishigami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Cahet\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e1ssia Maria","family":"Zoccoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,22]]},"reference":[{"key":"2024050202513119500_dkae075-B1","author":"WHO"},{"key":"2024050202513119500_dkae075-B2","doi-asserted-by":"crossref","first-page":"548","DOI":"10.2471\/BLT.18.228486","article-title":"Chlamydia, gonorrhoea, trichomoniasis and syphilis: global prevalence and incidence estimates, 2016","volume":"97","author":"Rowley","year":"2019","journal-title":"Bull World Health Organ"},{"key":"2024050202513119500_dkae075-B3","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/s41572-019-0128-6","article-title":"Gonorrhoea","volume":"5","author":"Unemo","year":"2019","journal-title":"Nat Rev Dis Primers"},{"key":"2024050202513119500_dkae075-B4","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s12864-020-6511-6","article-title":"Genomic evolution of Neisseria gonorrhoeae since the preantibiotic era (1928\u20132013): antimicrobial use\/misuse selects for resistance and drives evolution","volume":"21","author":"Golparian","year":"2020","journal-title":"BMC Genomics"},{"key":"2024050202513119500_dkae075-B5","doi-asserted-by":"crossref","DOI":"10.1177\/0956462420949126","article-title":"2020 European guideline for the diagnosis and treatment of gonorrhoea in adults","author":"Unemo","year":"2020","journal-title":"Int J STD AIDS"},{"key":"2024050202513119500_dkae075-B6","author":"WHO","year":"2016"},{"key":"2024050202513119500_dkae075-B7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.rr7004a1","article-title":"Sexually transmitted infections treatment guidelines, 2021","volume":"70","author":"Workowski","year":"2021","journal-title":"MMWR Recomm Rep"},{"key":"2024050202513119500_dkae075-B8","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1177\/0956462419886775","article-title":"2018 UK national guideline for the management of infection with Neisseria gonorrhoeae","volume":"31","author":"Fifer","year":"2020","journal-title":"Int J STD AIDS"},{"key":"2024050202513119500_dkae075-B9","doi-asserted-by":"crossref","first-page":"e627","DOI":"10.1016\/S2666-5247(21)00171-3","article-title":"WHO global antimicrobial resistance surveillance for Neisseria gonorrhoeae 2017\u201318: a retrospective observational study","volume":"2","author":"Unemo","year":"2021","journal-title":"Lancet Microbe"},{"key":"2024050202513119500_dkae075-B10","doi-asserted-by":"crossref","first-page":"4339","DOI":"10.1128\/AAC.00504-16","article-title":"New ceftriaxone- and multidrug-resistant Neisseria gonorrhoeae strain with a novel mosaic penA gene isolated in Japan","volume":"60","author":"Nakayama","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"2024050202513119500_dkae075-B11","doi-asserted-by":"crossref","first-page":"735","DOI":"10.3201\/eid2404.171873","article-title":"Cooperative recognition of internationally disseminated ceftriaxone-resistant Neisseria gonorrhoeae strain","volume":"24","author":"Lahra","year":"2018","journal-title":"Emerg Infect Dis"},{"key":"2024050202513119500_dkae075-B12","doi-asserted-by":"crossref","first-page":"1900147","DOI":"10.2807\/1560-7917.ES.2019.24.10.1900147","article-title":"Detection in the United Kingdom of the Neisseria gonorrhoeae FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, October to December 2018","volume":"24","author":"Eyre","year":"2019","journal-title":"Euro Surveill"},{"key":"2024050202513119500_dkae075-B13","doi-asserted-by":"crossref","first-page":"2200803","DOI":"10.2807\/1560-7917.ES.2022.27.46.2200803","article-title":"Detection of 10 cases of ceftriaxone-resistant Neisseria gonorrhoeae in the United Kingdom, December 2021 to June 2022","volume":"27","author":"Day","year":"2022","journal-title":"Euro Surveill"},{"key":"2024050202513119500_dkae075-B14","doi-asserted-by":"crossref","first-page":"1800617","DOI":"10.2807\/1560-7917.ES.2018.23.47.1800617","article-title":"Multidrug-resistant Neisseria gonorrhoeae isolate, belonging to the internationally spreading Japanese FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, Ireland, August 2018","volume":"23","author":"Golparian","year":"2018","journal-title":"Euro Surveill"},{"key":"2024050202513119500_dkae075-B15","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1093\/jac\/dkz129","article-title":"Clonal expansion and spread of the ceftriaxone-resistant Neisseria gonorrhoeae strain FC428, identified in Japan in 2015, and closely related isolates","volume":"74","author":"Lee","year":"2019","journal-title":"J Antimicrob Chemother"},{"key":"2024050202513119500_dkae075-B16","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/IM9.0000000000000113","article-title":"Global transmission of the penA allele 60.001\u2013containing high-level ceftriaxone-resistant gonococcal FC428 clone and antimicrobial therapy of associated cases: a review","volume":"5","author":"van der Veen","year":"2023","journal-title":"Infect Microb Dis"},{"key":"2024050202513119500_dkae075-B17","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12941-023-00587-x","article-title":"Dissemination of Neisseria gonorrhoeae with decreased susceptibility to extended-spectrum cephalosporins in Southern China, 2021: a genome-wide surveillance from 20 cities","volume":"22","author":"Liao","year":"2023","journal-title":"Ann Clin Microbiol Antimicrob"},{"key":"2024050202513119500_dkae075-B18","doi-asserted-by":"crossref","first-page":"1800323","DOI":"10.2807\/1560-7917.ES.2018.23.27.1800323","article-title":"Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018","volume":"23","author":"Eyre","year":"2018","journal-title":"Euro Surveill"},{"key":"2024050202513119500_dkae075-B19","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S1473-3099(18)30340-2","article-title":"Genetic characterisation of Neisseria gonorrhoeae resistant to both ceftriaxone and azithromycin","volume":"18","author":"Whiley","year":"2018","journal-title":"Lancet Infect Dis"},{"key":"2024050202513119500_dkae075-B20","doi-asserted-by":"crossref","first-page":"2200455","DOI":"10.2807\/1560-7917.ES.2022.27.24.2200455","article-title":"Extensively drug-resistant (XDR) Neisseria gonorrhoeae causing possible gonorrhoea treatment failure with ceftriaxone plus azithromycin in Austria, April 2022","volume":"27","author":"Pleininger","year":"2022","journal-title":"Euro Surveill"},{"key":"2024050202513119500_dkae075-B21","doi-asserted-by":"crossref","first-page":"2300125","DOI":"10.2807\/1560-7917.ES.2023.28.10.2300125","article-title":"Multidrug-resistant Neisseria gonorrhoeae isolate SE690: mosaic penA-60.001 gene causing ceftriaxone resistance internationally has spread to the more antimicrobial-susceptible genomic lineage, Sweden, September 2022","volume":"28","author":"Golparian","year":"2023","journal-title":"Euro Surveill"},{"key":"2024050202513119500_dkae075-B22","author":"Minist\u00e9rio da Sa\u00fade"},{"key":"2024050202513119500_dkae075-B23","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1093\/jac\/dky090","article-title":"First nationwide antimicrobial susceptibility surveillance for Neisseria gonorrhoeae in Brazil, 2015\u201316","volume":"73","author":"Bazzo","year":"2018","journal-title":"J Antimicrob Chemother"},{"key":"2024050202513119500_dkae075-B24","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.1093\/jac\/dkaa318","article-title":"Genomic epidemiology of Neisseria gonorrhoeae elucidating the gonococcal antimicrobial resistance and lineages\/sublineages across Brazil, 2015\u201316","volume":"75","author":"Golparian","year":"2020","journal-title":"J Antimicrob Chemother"},{"key":"2024050202513119500_dkae075-B25","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1038\/s41564-019-0501-y","article-title":"The impact of antimicrobials on gonococcal evolution","volume":"4","author":"S\u00e1nchez-Bus\u00f3","year":"2019","journal-title":"Nat Microbiol"},{"key":"2024050202513119500_dkae075-B26","doi-asserted-by":"crossref","first-page":"505","DOI":"10.3201\/eid2603.190732","article-title":"Genomic and phenotypic variability in Neisseria gonorrhoeae antimicrobial susceptibility, England","volume":"26","author":"Town","year":"2020","journal-title":"Emerg Infect Dis"},{"key":"2024050202513119500_dkae075-B27","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1093\/jac\/dkac158","article-title":"Genomic surveillance and antimicrobial resistance in Neisseria gonorrhoeae isolates in Bangkok, Thailand in 2018","volume":"77","author":"Golparian","year":"2022","journal-title":"J Antimicrob Chemother"},{"key":"2024050202513119500_dkae075-B28","doi-asserted-by":"crossref","first-page":"820998","DOI":"10.3389\/fmicb.2021.820998","article-title":"First national genomic epidemiological study of Neisseria gonorrhoeae strains spreading across Sweden in 2016","volume":"12","author":"Hadad","year":"2022","journal-title":"Front Microbiol"},{"key":"2024050202513119500_dkae075-B29","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/S1473-3099(16)30157-8","article-title":"Whole-genome sequencing to determine transmission of Neisseria gonorrhoeae: an observational study","volume":"16","author":"De Silva","year":"2016","journal-title":"Lancet Infect Dis"},{"key":"2024050202513119500_dkae075-B30","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/978-1-4939-9496-0_4","article-title":"Prediction of minimum inhibitory concentrations of antimicrobials for Neisseria gonorrhoeae using whole-genome sequencing","volume":"1997","author":"Eyre","year":"2019","journal-title":"Methods Mol Biol"},{"key":"2024050202513119500_dkae075-B31","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s13073-021-00858-2","article-title":"A community-driven resource for genomic epidemiology and antimicrobial resistance prediction of Neisseria gonorrhoeae at pathogenwatch","volume":"13","author":"S\u00e1nchez-Bus\u00f3","year":"2021","journal-title":"Genome Med"},{"key":"2024050202513119500_dkae075-B32","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1093\/jac\/dkac366","article-title":"GyrB in silico mining in 27 151 global gonococcal genomes from 1928\u20132021 combined with zoliflodacin in vitro testing of 71 international gonococcal isolates with different GyrB, ParC and ParE substitutions confirms high susceptibility","volume":"78","author":"Golparian","year":"2022","journal-title":"J Antimicrob Chemother"},{"key":"2024050202513119500_dkae075-B33","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/S1473-3099(18)30225-1","article-title":"Public health surveillance of multidrug-resistant clones of Neisseria gonorrhoeae in Europe: a genomic survey","volume":"18","author":"Harris","year":"2018","journal-title":"Lancet Infect Dis"},{"key":"2024050202513119500_dkae075-B34","doi-asserted-by":"crossref","first-page":"e452","DOI":"10.1016\/S2666-5247(22)00044-1","article-title":"Europe-wide expansion and eradication of multidrug-resistant Neisseria gonorrhoeae lineages: a genomic surveillance study","volume":"3","author":"S\u00e1nchez-Bus\u00f3","year":"2022","journal-title":"Lancet Microbe"},{"key":"2024050202513119500_dkae075-B35","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1093\/jac\/dkaa040","article-title":"Genomic analysis and antimicrobial resistance in Neisseria gonorrhoeae isolates from Vietnam in 2011 and 2015\u20132016","volume":"75","author":"Lan","year":"2020","journal-title":"J Antimicrobial Chemother"},{"key":"2024050202513119500_dkae075-B36","doi-asserted-by":"crossref","first-page":"dlac076","DOI":"10.1093\/jacamr\/dlac076","article-title":"National surveillance of Neisseria gonorrhoeae antimicrobial susceptibility and epidemiological data of gonorrhoea patients across Brazil, 2018\u201320","volume":"4","author":"Machado","year":"2022","journal-title":"JAC Antimicrob Resist"},{"key":"2024050202513119500_dkae075-B37","doi-asserted-by":"crossref","first-page":"3741","DOI":"10.1128\/JCM.40.10.3741-3749.2002","article-title":"Molecular epidemiology of Neisseria gonorrhoeae: sequence analysis of the porB gene confirms presence of two circulating strains","volume":"40","author":"Unemo","year":"2002","journal-title":"J Clin Microbiol"},{"key":"2024050202513119500_dkae075-B38","volume-title":"Performance Standards for Antimicrobial Susceptibility Testing\u2014Thirty-Second Edition: M100","author":"CLSI","year":"2022"},{"key":"2024050202513119500_dkae075-B39","author":"EUCAST"},{"key":"2024050202513119500_dkae075-B40","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1186\/s12879-015-1029-2","article-title":"Current and future antimicrobial treatment of gonorrhoea\u2014the rapidly evolving Neisseria gonorrhoeae continues to challenge","volume":"15","author":"Unemo","year":"2015","journal-title":"BMC Infect Dis"},{"key":"2024050202513119500_dkae075-B41","doi-asserted-by":"crossref","first-page":"19792","DOI":"10.2807\/ese.16.06.19792-en","article-title":"Ceftriaxone treatment failure of pharyngeal gonorrhoea verified by international recommendations, Sweden, July 2010","volume":"16","author":"Unemo","year":"2011","journal-title":"Euro Surveill"},{"key":"2024050202513119500_dkae075-B42","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1071\/SH19023","article-title":"World health organization global gonococcal antimicrobial surveillance program (WHO GASP): review of new data and evidence to inform international collaborative actions and research efforts","volume":"16","author":"Unemo","year":"2019","journal-title":"Sex Health"},{"key":"2024050202513119500_dkae075-B43","doi-asserted-by":"crossref","first-page":"3096","DOI":"10.1093\/jac\/dkw288","article-title":"The novel 2016 WHO Neisseria gonorrhoeae reference strains for global quality assurance of laboratory investigations: phenotypic, genetic and reference genome characterization","volume":"71","author":"Unemo","year":"2016","journal-title":"J Antimicrob Chemother"},{"key":"2024050202513119500_dkae075-B44","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1093\/jac\/dkaa552","article-title":"Neisseria gonorrhoeae Sequence Typing for Antimicrobial Resistance (NG-STAR) clonal complexes are consistent with genomic phylogeny and provide simple nomenclature, rapid visualization and antimicrobial resistance (AMR) lineage predictions","volume":"76","author":"Golparian","year":"2021","journal-title":"J Antimicrob Chemother"},{"key":"2024050202513119500_dkae075-B45","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/1471-2105-10-152","article-title":"Global optimal eBURST analysis of multilocus typing data using a graphic matroid approach","volume":"10","author":"Francisco","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"2024050202513119500_dkae075-B46","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/1471-2105-13-87","article-title":"PHYLOViz: phylogenetic inference and data visualization for sequence based typing methods","volume":"13","author":"Francisco","year":"2012","journal-title":"BMC Bioinformatics"},{"key":"2024050202513119500_dkae075-B47","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1093\/molbev\/msu300","article-title":"IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies","volume":"32","author":"Nguyen","year":"2015","journal-title":"Mol Biol Evol"},{"key":"2024050202513119500_dkae075-B48","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1093\/nar\/gku1196","article-title":"Rapid phylogenetic analysis of large samples of recombinant bacterial whole genome sequences using gubbins","volume":"43","author":"Croucher","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"2024050202513119500_dkae075-B49","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1093\/jac\/dkz054","article-title":"Genome-based epidemiology and antimicrobial resistance determinants of Neisseria gonorrhoeae isolates with decreased susceptibility and resistance to extended-spectrum cephalosporins in Argentina in 2011\u201316","volume":"74","author":"Gianecini","year":"2019","journal-title":"J Antimicrob Chemother"},{"key":"2024050202513119500_dkae075-B50","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.3201\/eid2709.204843","article-title":"Genomic epidemiology of azithromycin-nonsusceptible Neisseria gonorrhoeae, Argentina, 2005\u20132019","volume":"27","author":"Gianecini","year":"2021","journal-title":"Emerg Infect Dis"},{"key":"2024050202513119500_dkae075-B51","first-page":"e000093","article-title":"Microreact: visualizing and sharing data for genomic epidemiology and phylogeography","volume":"2","author":"Argim\u00f3n","year":"2016","journal-title":"Microb Genom"},{"key":"2024050202513119500_dkae075-B52","doi-asserted-by":"crossref","first-page":"e0221068","DOI":"10.1371\/journal.pone.0221068","article-title":"TreeCluster: clustering biological sequences using phylogenetic trees","volume":"14","author":"Balaban","year":"2019","journal-title":"PLoS One"},{"key":"2024050202513119500_dkae075-B53","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1093\/molbev\/msab120","article-title":"MEGA11: molecular evolutionary genetics analysis version 11","volume":"38","author":"Tamura","year":"2021","journal-title":"Mol Biol Evol"},{"key":"2024050202513119500_dkae075-B54","author":"Seabold"},{"key":"2024050202513119500_dkae075-B55","doi-asserted-by":"crossref","first-page":"4126","DOI":"10.1038\/s41467-020-17980-1","article-title":"Adaptation to the cervical environment is associated with increased antibiotic susceptibility in Neisseria gonorrhoeae","volume":"11","author":"Ma","year":"2020","journal-title":"Nat Commun"},{"key":"2024050202513119500_dkae075-B56","doi-asserted-by":"crossref","first-page":"5374","DOI":"10.1038\/s41467-020-19250-6","article-title":"Increased power from conditional bacterial genome-wide association identifies macrolide resistance mutations in Neisseria gonorrhoeae","volume":"11","author":"Ma","year":"2020","journal-title":"Nat Commun"},{"key":"2024050202513119500_dkae075-B57","doi-asserted-by":"crossref","first-page":"e01221","DOI":"10.1128\/AAC.01221-18","article-title":"Microbiological analysis from a phase 2 randomized study in adults evaluating single oral doses of gepotidacin in the treatment of uncomplicated urogenital gonorrhea caused by Neisseria gonorrhoeae","volume":"62","author":"Scangarella-Oman","year":"2018","journal-title":"Antimicrob Agents Chemother"},{"key":"2024050202513119500_dkae075-B58","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1093\/jac\/dkad168","article-title":"High-level in vitro resistance to gentamicin acquired in a stepwise manner in Neisseria gonorrhoeae","volume":"78","author":"Golparian","year":"2023","journal-title":"J Antimicrob Chemother"},{"key":"2024050202513119500_dkae075-B59","article-title":"Genomic analysis of 1710 surveillance-based Neisseria gonorrhoeae isolates from the USA in 2019 identifies predominant strain types and chromosomal antimicrobial-resistance determinants","volume":"9","author":"Reimche","year":"2023","journal-title":"Microb Genom"},{"key":"2024050202513119500_dkae075-B60","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/nrurol.2016.268","article-title":"Antimicrobial-resistant sexually transmitted infections: gonorrhoea and Mycoplasma genitalium","volume":"14","author":"Unemo","year":"2017","journal-title":"Nat Rev Urol"},{"key":"2024050202513119500_dkae075-B61","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1093\/jac\/dky548","article-title":"Pharmacokinetic considerations regarding the treatment of bacterial sexually transmitted infections with azithromycin: a review","volume":"74","author":"Kong","year":"2019","journal-title":"J Antimicrob Chemother"},{"key":"2024050202513119500_dkae075-B62","doi-asserted-by":"crossref","first-page":"844818","DOI":"10.3389\/fphar.2022.844818","article-title":"Consumption trends of antibiotics in Brazil during the COVID-19 pandemic","volume":"13","author":"Del Fiol","year":"2022","journal-title":"Front Pharmacol"},{"key":"2024050202513119500_dkae075-B63","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1093\/cid\/ciy145","article-title":"Gepotidacin for the treatment of uncomplicated urogenital gonorrhea: a phase 2, randomized, dose-ranging, single-oral dose evaluation","volume":"67","author":"Taylor","year":"2018","journal-title":"Clin Infect Dis"},{"key":"2024050202513119500_dkae075-B64","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1056\/NEJMoa1706988","article-title":"Single-dose zoliflodacin (ETX0914) for treatment of urogenital gonorrhea","volume":"379","author":"Taylor","year":"2018","journal-title":"New Engl J Med"},{"key":"2024050202513119500_dkae075-B65","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1093\/jac\/dky162","article-title":"In vitro activity of the novel triazaacenaphthylene gepotidacin (GSK2140944) against MDR Neisseria gonorrhoeae","volume":"73","author":"Jacobsson","year":"2018","journal-title":"J Antimicrob Chemother"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jac\/article-pdf\/79\/5\/1081\/57368149\/dkae075.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jac\/article-pdf\/79\/5\/1081\/57368149\/dkae075.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T02:52:58Z","timestamp":1714618378000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article\/79\/5\/1081\/7633595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,22]]},"references-count":65,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,3,22]]},"published-print":{"date-parts":[[2024,5,2]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dkae075","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,5]]},"published":{"date-parts":[[2024,3,22]]}}}