{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T14:39:56Z","timestamp":1778769596372,"version":"3.51.4"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32273003;"],"award-info":[{"award-number":["32273003;"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2022NSFSC0007"],"award-info":[{"award-number":["2022NSFSC0007"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2022NSFSC0080"],"award-info":[{"award-number":["2022NSFSC0080"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012453","name":"China Agricultural Research System","doi-asserted-by":"publisher","award":["CARS-42-17"],"award-info":[{"award-number":["CARS-42-17"]}],"id":[{"id":"10.13039\/501100012453","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sichuan Veterinary Medicine and Drug Innovation Group of the China Agricultural Research System","award":["SCCXTD-2020-18"],"award-info":[{"award-number":["SCCXTD-2020-18"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Riemerella anatipestifer encodes an iron acquisition system, but whether it encodes the iron efflux pump and its role in antibiotic resistance are largely unknown.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To screen and identify an iron efflux gene in R. anatipestifer and determine whether and how the iron efflux gene is involved in antibiotic resistance.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this study, gene knockout, streptonigrin susceptibility assay and inductively coupled plasma mass spectrometry were used to screen for the iron efflux gene ietA. The MIC measurements, scanning electron microscopy and reactive oxygen species (ROS) detection were used to verify the role of IetA in aztreonam resistance and its mechanism. Mortality and colonization assay were used to investigate the role of IetA in virulence.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The deletion mutant \u0394ietA showed heightened susceptibility to streptonigrin, and prominent intracellular iron accumulation was observed in \u0394fur\u0394ietA under excess iron conditions. Additionally, \u0394ietA exhibited increased sensitivity to H2O2-produced oxidative stress. Under aerobic conditions with abundant iron, \u0394ietA displayed increased susceptibility to the \u03b2-lactam antibiotic aztreonam due to heightened ROS production. However, the killing efficacy of aztreonam was diminished in both WT and \u0394ietA under anaerobic or iron restriction conditions. Further experiments demonstrated that the efficiency of aztreonam against \u0394ietA was dependent on respiratory complexes \u2160 and \u2161. Finally, in a duckling model, \u0394ietA had reduced virulence compared with the WT.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Iron efflux is critical to alleviate oxidative stress damage and \u03b2-lactam aztreonam killing in R. anatipestifer, which is linked by cellular respiration.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkae114","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T19:01:21Z","timestamp":1713380481000},"page":"1385-1396","source":"Crossref","is-referenced-by-count":8,"title":["Iron efflux by IetA enhances \u03b2-lactam aztreonam resistance and is linked to oxidative stress through cellular respiration in <i>Riemerella anatipestifer<\/i>"],"prefix":"10.1093","volume":"79","author":[{"given":"Mafeng","family":"Liu","sequence":"first","affiliation":[{"name":"Engineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China , Chengdu 611130 , China"},{"name":"Key Laboratory of Animal Disease and Human Health of Sichuan Province , Chengdu 611130 , China"},{"name":"International Joint Research Center for Animal Disease Prevention and Control of Sichuan Province , Chengdu 611130 , China"},{"name":"Research Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University , Chengdu 611130 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengying","family":"Wang","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China , Chengdu 611130 , China"},{"name":"Key Laboratory of Animal Disease and Human Health of Sichuan Province , Chengdu 611130 , China"},{"name":"International Joint Research Center for Animal Disease Prevention and 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