{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:52:45Z","timestamp":1781830365782,"version":"3.54.5"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100006451","name":"Hospices Civils de Lyon","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006451","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Invasive candidiasis is still recognized as a major cause of morbidity and mortality. To support clinicians in the optimal use of antifungals for the treatment of invasive candidiasis, a computerized decision support system (CDSS) was developed based on institutional guidelines.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To evaluate the correlation of this newly developed CDSS with clinical practices, we set-up a retrospective multicentre cohort study with the aim of providing the concordance rate between the CDSS recommendation and the medical prescription (NCT05656157).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients and methods<\/jats:title>\n                  <jats:p>Adult patients who received caspofungin or fluconazole for the treatment of an invasive candidiasis were included. The analysis of factors associated with concordance was performed using mixed logistic regression models with department as a random effect.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>From March to November 2022, 190 patients were included from three centres and eight departments: 70 patients from centre A, 84 from centre B and 36 from centre C. Overall, 100 patients received caspofungin and 90 received fluconazole, mostly (59%; 112\/190) for empirical\/pre-emptive treatment. The overall percentage of concordance between the CDSS and medical prescriptions was 91% (173\/190) (confidence interval 95%: 82%\u201396%). No significant difference in concordance was observed considering the centres (P\u200a&amp;gt;\u200a0.99), the department of inclusion (P\u200a=\u200a0.968), the antifungal treatment (P\u200a=\u200a0.656) or the indication of treatment (P\u200a=\u200a0.997). In most cases of discordance (n\u200a=\u200a13\/17, 76%), the CDSS recommended fluconazole whereas caspofungin was prescribed. The clinical usability evaluated by five clinicians was satisfactory.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our results demonstrated the high correlation between current antifungal clinical practice and this user-friendly and institutional guidelines-based CDSS.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkae118","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T15:26:04Z","timestamp":1713972364000},"page":"1407-1412","source":"Crossref","is-referenced-by-count":2,"title":["Correlation between antifungal clinical practices and a new clinical decision support system ANTIFON-CLIC\u00ae for the treatment of invasive candidiasis: a retrospective multicentre study"],"prefix":"10.1093","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1502-1851","authenticated-orcid":false,"given":"Anne-Lise","family":"Bienvenu","sequence":"first","affiliation":[{"name":"Service Pharmacie, Groupement Hospitalier Nord, Hospices Civils de Lyon , Lyon , France"},{"name":"Univ Lyon, Malaria Research Unit, SMITh, ICBMS UMR 5246 , Lyon , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4909-9761","authenticated-orcid":false,"given":"Martin","family":"Cour","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive-R\u00e9animation, Groupement Hospitalier Centre, Hospices Civils de Lyon , Lyon , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Pavese","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses, CHU de Grenoble , Grenoble , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Guichon","sequence":"additional","affiliation":[{"name":"Service d\u2019Anesth\u00e9sie-R\u00e9animation, Groupement Hospitalier Nord, Hospices Civils de Lyon , Lyon , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Leray","sequence":"additional","affiliation":[{"name":"Service d\u2019Anesth\u00e9sie-R\u00e9animation, Groupement Hospitalier Centre, Hospices Civils de Lyon , Lyon , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Chapuis","sequence":"additional","affiliation":[{"name":"Service de Pharmacie, CHU de Grenoble , Grenoble , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie","family":"Dureault","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses, CH de Valence , Valence , 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wajih","family":"Chaabane","sequence":"additional","affiliation":[{"name":"Direction des Services Num\u00e9riques, Hospices Civils de Lyon , Lyon , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Subtil","sequence":"additional","affiliation":[{"name":"Service de Biostatistique-Bioinformatique, Hospices Civils de Lyon , Lyon , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Maucort-Boulch","sequence":"additional","affiliation":[{"name":"Service de Biostatistique-Bioinformatique, Hospices Civils de Lyon , Lyon , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Talbot","sequence":"additional","affiliation":[{"name":"Direction des Services Num\u00e9riques, Hospices Civils de Lyon , Lyon , 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