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The clinical characteristics, outcomes, antimicrobial susceptibility and genomic epidemiology of cases with S. maltophilia were investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 78 patients were included representing 34 infection and 44 colonization cases. The median age was 72.5\u2005years (IQR, 61\u201378), and males accounted for 53 cases (68%). The most common comorbidity was localized solid malignancy (39%). Nearly half of the patients (44%) were immunosuppressed, with antineoplastic chemotherapy accounting for 31%. The respiratory tract was the most common site of colonization (86%), whereas bacteraemia accounted for most infection cases (56%). The 30 day all-cause mortality rate was 21%, which was significantly higher in infection cases than colonization cases (35% versus 9%; adjusted HR, 3.81; 95% CI, 1.22\u201311.96). Susceptibility rates to ceftazidime, levofloxacin, minocycline and sulfamethoxazole\/trimethoprim were 14%, 65%, 87% and 100%, respectively. The percentage of infection ranged from 13% in the unclassified group to 86% in genomic group 6A. The percentage of non-susceptibility to ceftazidime ranged from 33% in genomic group C to 100% in genomic groups 6 and 7 and genomic group geniculate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this contemporary multicentre cohort, S. maltophilia primarily colonized the respiratory tract, whereas patients with bacteraemia had the highest the mortality from this pathogen. Sulfamethoxazole\/trimethoprim remained consistently active, but susceptibility to levofloxacin was relatively low. The proportions of cases representing infection and susceptibility to ceftazidime differed significantly based on genomic groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jac\/dkae168","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T08:46:45Z","timestamp":1715244405000},"page":"1843-1855","source":"Crossref","is-referenced-by-count":13,"title":["Clinical characteristics and genome epidemiology of\n                    <i>Stenotrophomonas maltophilia<\/i>\n                    in Japan"],"prefix":"10.1093","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3135-1757","authenticated-orcid":false,"given":"Ryota","family":"Hase","sequence":"first","affiliation":[{"name":"Department of Microbiology, Fujita Health University School of Medicine , Toyoake, Aichi , Japan"},{"name":"Department of Infectious Diseases, Japanese Red Cross Narita Hospital , Narita, Chiba , Japan"},{"name":"Department of Infectious Diseases, Kameda 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