{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T08:58:05Z","timestamp":1769763485156,"version":"3.49.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T00:00:00Z","timestamp":1719014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["112-2314-B-002-037"],"award-info":[{"award-number":["112-2314-B-002-037"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["112-2628-B-002-020-MY3"],"award-info":[{"award-number":["112-2628-B-002-020-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare, Taiwan","doi-asserted-by":"publisher","award":["MOHW111-TDU-B-211-134002"],"award-info":[{"award-number":["MOHW111-TDU-B-211-134002"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare, Taiwan","doi-asserted-by":"publisher","award":["MOHW112-TDU-B-211-144002"],"award-info":[{"award-number":["MOHW112-TDU-B-211-144002"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["112-M0021"],"award-info":[{"award-number":["112-M0021"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Genotyping isolates of a specific pathogen may demonstrate unique patterns of antimicrobial resistance, virulence or outcomes. However, evidence for genotype\u2013outcome association in Candida glabrata is scarce. We aimed to characterize the mycological and clinical relevance of genotypes on C. glabrata bloodstream infections (BSIs).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Non-duplicated C. glabrata blood isolates from hospitalized adults were genotyped by MLST, and further clustered by the unweighted pair group method with arithmetic averages (UPGMA). A clonal complex (CC) was defined by UPGMA similarities of &amp;gt;90%. Antifungal susceptibility testing was performed by a colorimetric microdilution method and interpreted following CLSI criteria.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 48 blood isolates evaluated, 13 STs were identified. CC7 was the leading CC (n\u200a=\u200a14; 29.2%), including 13 ST7. The overall fluconazole and echinocandin resistance rates were 6.6% and 0%, respectively. No specific resistance patterns were associated with CC7 or other CCs. Charlson comorbidity index (adjusted OR, 1.49; 95% CI, 1.05\u20133.11) was the only predictor for CC7. By multivariable Cox regression analyses, CC7 was independently associated with 28\u2005day mortality [adjusted HR (aHR), 3.28; 95% CI, 1.31\u20138.23], even after considering potential interaction with neutropenia (aHR, 3.41; 95% CI, 1.23\u20139.42; P for interaction, 0.24) or limited to 34 patients with monomicrobial BSIs (aHR, 2.85; 95% CI, 1.15\u20137.08). Also, the Kaplan\u2013Meier estimate showed greater mortality with CC7 (P\u200a=\u200a0.003). Fluconazole resistance or echinocandin therapy had no significant impact on mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our data suggested comorbid patients were at risk of developing CC7 BSIs. Further, CC7 was independently associated with worse outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkae200","type":"journal-article","created":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T02:31:50Z","timestamp":1719023510000},"page":"2008-2016","source":"Crossref","is-referenced-by-count":1,"title":["Implication of genotypes for prognosis of <i>Candida glabrata<\/i> bloodstream infections"],"prefix":"10.1093","volume":"79","author":[{"given":"Pao-Yu","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital , Taipei City , Taiwan"},{"name":"Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine , Taipei City , Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Shan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital , Taipei City , Taiwan"},{"name":"Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine , Taipei City , Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Chung","family":"Chuang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital , Taipei City , Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jann-Tay","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital , Taipei City , Taiwan"},{"name":"National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes , Taipei City , Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wang-Huei","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital , Taipei City , Taiwan"},{"name":"Department of Medicine, National Taiwan University College of Medicine , Taipei City , Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1816-9010","authenticated-orcid":false,"given":"Yee-Chun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital , Taipei City , Taiwan"},{"name":"National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes , Taipei City , Taiwan"},{"name":"Department of Medicine, National Taiwan University College of Medicine , Taipei City , Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan-Chwen","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital , Taipei City , Taiwan"},{"name":"Department of Medicine, National Taiwan University College of Medicine , Taipei City , 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