{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:35:36Z","timestamp":1787510136111,"version":"build-2736575974"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Viridans group streptococci (VGS) bloodstream infection (BSI) frequently occurs in cancer patients receiving chemotherapy, and is associated with infective endocarditis (IE) in up to 20% of cases in the general population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>In cancer patients receiving chemotherapy with VGS BSI, we aimed to: (i) determine the incidence of infective complications including IE, (ii) assess the utility of echocardiography in this patient population, (iii) determine the duration and type of antimicrobial therapy received for monomicrobial infections, and (iv) determine the evolution of antimicrobial resistance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>VGS BSIs (excluding Streptococcus pneumoniae and Streptococcus pseudopneumoniae) in cancer patients receiving chemotherapy were identified from a statewide public pathology database between 2013 and 2022 at our tertiary centre. Medical records were accessed for clinical, microbiological and radiological data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 581 patient episodes screened, 183 episodes involving 171 patients met inclusion criteria. Of these, 51% were bone marrow transplantation (BMT) patients, 40% were non-BMT haematology patients, and 8% were solid organ malignancy patients. The median age was 55 years, and 96% were neutropenic at the time of blood culture collection. A transthoracic echocardiogram was performed for 71% of episodes, and one patient met modified Duke\u2019s criteria for definite IE, although this diagnosis was not suspected on clinical grounds. Other complications were uncommon. Benzylpenicillin resistance was rare (2.9%) and did not change over time. Most episodes (75%) were treated with piperacillin\/tazobactam. For monomicrobial BSIs, the median antibiotic duration was 5 days (IQR 2\u20137) post-neutropenia resolution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Infective complications and antimicrobial resistance are rare in cancer patients with VGS BSI. This may provide a safe opportunity to limit both investigations (e.g. echocardiogram) and prolonged exposure to broad-spectrum antimicrobials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jac\/dkae209","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T05:51:41Z","timestamp":1718344301000},"page":"2040-2047","source":"Crossref","is-referenced-by-count":1,"title":["Low rates of complications and \u03b2-lactam resistance in viridans group streptococci bloodstream infection among cancer patients receiving chemotherapy"],"prefix":"10.1093","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8661-1923","authenticated-orcid":false,"given":"Joshua","family":"Sheehy","sequence":"first","affiliation":[{"name":"Department of Haematology and Bone Marrow Transplant, Royal Brisbane and Women\u2019s Hospital , Herston, QLD , Australia"},{"name":"Faculty of Medicine, The University of Queensland , Brisbane, QLD , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashleigh P","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Haematology and Bone Marrow Transplant, Royal Brisbane and Women\u2019s Hospital , Herston, QLD , Australia"},{"name":"Faculty of Medicine, The University of Queensland , Brisbane, QLD , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea S","family":"Henden","sequence":"additional","affiliation":[{"name":"Department of Haematology and Bone Marrow Transplant, Royal Brisbane and Women\u2019s Hospital , Herston, QLD , Australia"},{"name":"Faculty of Medicine, The University of Queensland , Brisbane, QLD , Australia"},{"name":"Translational Cancer Immunotherapy, QIMR Berghofer Medical Research Institute , Herston, QLD , 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